University of California San Francisco

diana.laird
Diana Laird, PhD

Professor, Ob/Gyn, Reproductive Sciences
School of Medicine

Address

35 Medical Center Way, #1015
San Francisco, CA 94143
United States

Email: [email protected]
Phone: 415-476-5471
Fax: 415-502-7866

ORCID: 0000-0002-4930-0560

Education

Institution Degree Dept or School End Date
Sloan Kettering Institute Postdoctoral Fellowship Developmental Biology 2007
Stanford University Ph.D. Biological Sciences 2003
Harvard University A.B. Physics 1995

Grants and Funding

  • Using the Ovary to Hack Aging | W.M. Keck Foundation | 2019-01-01 - 2022-12-31 | Role:
  • The intersection of stress and environmental chemicals in germ cell reprogramming | NIH | 2017-09-15 - 2022-08-31 | Role: Principal Investigator
  • Fmr1 Function and Repeat Expansion in the Developing Germline | NIH | 2017-12-26 - 2021-11-30 | Role: Principal Investigator
  • Assessing transgenerational effects of Phthalates on primordial germ cells | NIH | 2013-08-29 - 2017-07-31 | Role: Principal Investigator
  • The 2014 Santa Cruz Developmental Biology Meeting | NIH | 2014-07-15 - 2015-06-30 | Role: Principal Investigator
  • Cell competition in the developing mouse germline | NIH | 2010-09-30 - 2015-06-30 | Role: Principal Investigator
  • The UCSF Environmental Research and Translation for Health (EaRTH) Center - Pilot Program | NIH/NIEHS | - | Role: Deputy Director and Pilot Core Director

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 55
  1. Mammalian oocytes receive maternal-effect RNAs from granulosa cells.
    Doherty CA, Tijjani A, Munger SC, Laird DJ| | PubMed
  2. Defining the cell and molecular origins of the primate ovarian reserve.
    Wamaitha SE, Rojas EJ, Monticolo F, Hsu FM, Sosa E, Mackie AM, Oyama K, Custer M, Murphy M, Laird DJ, Shu J, Hennebold JD, Clark AT| | PubMed
  3. An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology.
    Sokolowski DJ, Miclaus M, Nater A, Faykoo-Martinez M, Hoekzema K, Zuzarte P, Monis S, Alvi SA, Erdmann J, Erdmann AL, Kumaragurubaran R, Bayerl J, Yoo D, Karimpour N, Ungerleider K, Hou H, Fergal M, Hourlier T, Clarke ZA, Lischer HE, Leordean DV, Jiang Y, Pugh TJ, Smith ESJ, Haggerty L, Laird DJ, Lilue J, Holmes MM, Eichler EE, Bruggmann R, Simpson JT, Balmus G, Wilson MD| | PubMed
  4. Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants.
    Jaszczak RG, Zussman JW, Wagner DE, Laird DJ| | PubMed
  5. Sustained fertility from first-wave follicle oocytes that pause their growth.
    Soygur B, Gaylord EA, Foecke MH, Cincotta SA, Horan TS, Wood A, Cohen PE, Laird DJ| | PubMed
  6. Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.
    Borges B, Varthaliti A, Schwab M, Clarke MT, Pivetti C, Gupta N, Cadwell CR, Guibinga G, Phillips S, Del Rio T, Ozsolak F, Imai-Leonard D, Kong L, Laird DJ, Herzeg A, Sumner CJ, MacKenzie TC| | PubMed
  7. Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions.
    Prasasya RD, Caldwell BA, Liu Z, Wu S, Leu NA, Fowler JM, Cincotta SA, Laird DJ, Kohli RM, Bartolomei MS| | PubMed
  8. Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
    Cincotta SA, Richardson N, Foecke MH, Laird DJ| | PubMed
  9. Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
    Steven A Cincotta, Nainoa Richardson, Mariko H Foecke, Diana J Laird| | UCSF Research Profile
  10. Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
    Cincotta SA, Richardson N, Foecke MH, Laird DJ| | PubMed
55
View all 55 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 55
  1. Mammalian oocytes receive maternal-effect RNAs from granulosa cells.
    Doherty CA, Tijjani A, Munger SC, Laird DJ| | PubMed
  2. Defining the cell and molecular origins of the primate ovarian reserve.
    Wamaitha SE, Rojas EJ, Monticolo F, Hsu FM, Sosa E, Mackie AM, Oyama K, Custer M, Murphy M, Laird DJ, Shu J, Hennebold JD, Clark AT| | PubMed
  3. An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology.
    Sokolowski DJ, Miclaus M, Nater A, Faykoo-Martinez M, Hoekzema K, Zuzarte P, Monis S, Alvi SA, Erdmann J, Erdmann AL, Kumaragurubaran R, Bayerl J, Yoo D, Karimpour N, Ungerleider K, Hou H, Fergal M, Hourlier T, Clarke ZA, Lischer HE, Leordean DV, Jiang Y, Pugh TJ, Smith ESJ, Haggerty L, Laird DJ, Lilue J, Holmes MM, Eichler EE, Bruggmann R, Simpson JT, Balmus G, Wilson MD| | PubMed
  4. Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants.
    Jaszczak RG, Zussman JW, Wagner DE, Laird DJ| | PubMed
  5. Sustained fertility from first-wave follicle oocytes that pause their growth.
    Soygur B, Gaylord EA, Foecke MH, Cincotta SA, Horan TS, Wood A, Cohen PE, Laird DJ| | PubMed
  6. Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.
    Borges B, Varthaliti A, Schwab M, Clarke MT, Pivetti C, Gupta N, Cadwell CR, Guibinga G, Phillips S, Del Rio T, Ozsolak F, Imai-Leonard D, Kong L, Laird DJ, Herzeg A, Sumner CJ, MacKenzie TC| | PubMed
  7. Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions.
    Prasasya RD, Caldwell BA, Liu Z, Wu S, Leu NA, Fowler JM, Cincotta SA, Laird DJ, Kohli RM, Bartolomei MS| | PubMed
  8. Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
    Cincotta SA, Richardson N, Foecke MH, Laird DJ| | PubMed
  9. Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
    Steven A Cincotta, Nainoa Richardson, Mariko H Foecke, Diana J Laird| | UCSF Research Profile
  10. Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
    Cincotta SA, Richardson N, Foecke MH, Laird DJ| | PubMed
  11. Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells.
    Gökbuget D, Lenshoek K, Boileau RM, Bayerl J, Huang H, Wiita AP, Laird DJ, Blelloch R| | PubMed
  12. Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.
    Samuel RM, Navickas A, Maynard A, Gaylord EA, Garcia K, Bhat S, Majd H, Richter MN, Elder N, Le D, Nguyen P, Shibata B, Llabata ML, Selleri L, Laird DJ, Darmanis S, Goodarzi H, Fattahi F| | PubMed
  13. Eggs made from male mouse stem cells using error-prone culture.
    Bayerl J, Laird DJ| | PubMed
  14. Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats.
    Brieño-Enríquez MA, Faykoo-Martinez M, Goben M, Grenier JK, McGrath A, Prado AM, Sinopoli J, Wagner K, Walsh PT, Lopa SH, Laird DJ, Cohen PE, Wilson MD, Holmes MM, Place NJ| | PubMed
  15. TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated Regions.
    Prasasya RD, Caldwell BA, Liu Z, Wu S, Leu NA, Fowler JM, Cincotta SA, Laird DJ, Kohli RM, Bartolomei MS| | PubMed
  16. A Roadmap for Three-Dimensional Analysis of the Intact Mouse Ovary.
    Soygur B, Foecke MH, Gaylord EA, Fries A, Li J, Arora R, Laird DJ| | PubMed
  17. Ovary Development: Insights From a Three-Dimensional Imaging Revolution.
    Soygur B, Laird DJ| | PubMed
  18. Natural selection at the cellular level: insights from male germ cell differentiation.
    Nguyen DH, Laird DJ| | PubMed
  19. Intercellular bridges coordinate the transition from pluripotency to meiosis in mouse fetal oocytes.
    Soygur B, Jaszczak RG, Fries A, Nguyen DH, Malki S, Hu G, Demir N, Arora R, Laird DJ| | PubMed
  20. Apoptosis in the fetal testis eliminates developmentally defective germ cell clones.
    Nguyen DH, Soygur B, Peng SP, Malki S, Hu G, Laird DJ| | PubMed
  21. MON-LB130 Glucocorticoid Receptor Signaling and Stress in the Developing Mammalian Germline.
    Steven Anthony Cincotta, Diana Laird| | UCSF Research Profile
  22. The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community.
    Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ| | PubMed
  23. Maternal vitamin C regulates reprogramming of DNA methylation and germline development.
    DiTroia SP, Percharde M, Guerquin MJ, Wall E, Collignon E, Ebata KT, Mesh K, Mahesula S, Agathocleous M, Laird DJ, Livera G, Ramalho-Santos M| | PubMed
  24. Heterogeneity of primordial germ cells.
    Nguyen DH, Jaszczak RG, Laird DJ| | PubMed
  25. Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells.
    Reznik B, Cincotta SA, Jaszczak RG, Mateo LJ, Shen J, Cao M, Baskin L, Ye P, An W, Laird DJ| | PubMed
  26. How to lose your inheritance.
    Laird DJ| | PubMed
  27. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.
    Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH| | PubMed
  28. A pilgrim's progress: Seeking meaning in primordial germ cell migration.
    Cantú AV, Laird DJ| | PubMed
  29. Smad4 regulates growth plate matrix production and chondrocyte polarity.
    Whitaker AT, Berthet E, Cantu A, Laird DJ, Alliston T| | PubMed
  30. Patterning of sharp cellular interfaces with a reconfigurable elastic substrate.
    Curtis A, Li DJ, DeVeale B, Onishi K, Kim MY, Blelloch R, Laird DJ, Hui EE| | PubMed
  31. Insights from imaging the implanting embryo and the uterine environment in three dimensions.
    Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice LC, Laird DJ| | PubMed
  32. ROR2 in the adult mouse testis.
    Arora R, Laird DJ| | PubMed
  33. Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling.
    Cantú AV, Altshuler-Keylin S, Laird DJ| | PubMed
  34. Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary.
    Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ| | PubMed
  35. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates.
    Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH| | PubMed
  36. DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
    Sousa Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M| | PubMed
  37. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity.
    Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice LC| | PubMed
  38. Follicle dynamics and global organization in the intact mouse ovary.
    Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ| | PubMed
  39. Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system.
    Arora R, Altman E, Tran ND, Laird DJ| | PubMed
  40. Wnt and Bmp fit germ cells to a T.
    Cantú AV, Laird DJ| | PubMed
  41. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
    Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M| | PubMed
  42. Humans put their eggs in more than one basket.
    Laird DJ| | PubMed
  43. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.
    Chen L, Faire M, Kissner MD, Laird DJ| | PubMed
  44. miR-372/let-7 axis regulates human primordial germ cell specification.
    N.D. Tran, M. Kissner, D. Laird, R. Blelloch| | UCSF Research Profile
  45. Ror2 enhances polarity and directional migration of primordial germ cells.
    Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV| | PubMed
  46. Lin28-let7-Blimp1 Circuitry regulates human primordial germ cells (hPGC) development from human embryonic stem cells (hESC).
    N.D. Tran, D. Laird, M. Kissner, M. Conti, R. Blelloch| | UCSF Research Profile
  47. Establishment and characterization of human germ cells derived from embryonic stem cells (hESCs).
    N.D. Tran, D. Laird, M. Kissner, D. Supramanyam, M. Conti, R. Blelloch| | UCSF Research Profile
  48. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
    Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H| | PubMed
  49. Stem cell trafficking in tissue development, growth, and disease.
    Laird DJ, von Andrian UH, Wagers AJ| | PubMed
  50. Stem cells are units of natural selection in a colonial ascidian.
    Laird DJ, De Tomaso AW, Weissman IL| | PubMed
  51. Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri.
    Laird DJ, Chang WT, Weissman IL, Lauzon RJ| | PubMed
  52. Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri.
    Laird DJ, De Tomaso AW| | PubMed
  53. Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri.
    Laird DJ, Weissman IL| | PubMed
  54. Continuous development precludes radioprotection in a colonial ascidian.
    Laird DJ, Weissman IL| | PubMed
  55. 50 million years of chordate evolution: seeking the origins of adaptive immunity.
    Laird DJ, De Tomaso AW, Cooper MD, Weissman IL| | PubMed