Single nuclei and spatial profiling of sacrococcygeal teratomas reveals cellular composition and X inactivation heterogeneity.
Rojas EJ, Giannikou K, Huang BJ, Cho SJ, Cordero MA, Pena D, Vu L, Bagrodia A, Derderian SC, MacKenzie TC, Laird DJ 2026-01-21
Comparative analysis of human and mouse ovaries across age.
Gaylord EA, Foecke MH, Samuel RM, Soygur B, Detweiler AM, McIntyre TI, Dorman LC, Borja M, Laird AE, Arjyal R, Du J, Gardner JM, Neff N, Fattahi F, Laird DJ 2025-12-11
Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants.
Rebecca Garrett Jaszczak, Jay W Zussman, Daniel E Wagner, Diana J Laird 2025-11-19
UCSF Research Profile
In vitro oogenesis breaks free of the ovary.
Zussman JW, Laird DJ 2025-11-03
A mechanical origin for implantation defects in embryos from aged females.
Cavanaugh KE, Franco-Oñate MJ, Laird DJ, Oakes PW, Alert R, Weiner OD 2025-10-01
Defining the cell and molecular origins of the primate ovarian reserve.
Wamaitha SE, Rojas EJ, Monticolo F, Hsu FM, Sosa E, Mackie AM, Oyama K, Custer M, Murphy M, Laird DJ, Shu J, Hennebold JD, Clark AT 2025-08-26
Evaluating Selective Quality Control in Mammalian Oogenesis: Evidence and Opportunities.
Zussman JW, Skinner DJ, Wagner DE, Shvartsman SY, Laird DJ 2025-08-08
Ancient viruses sustain mammalian reproduction.
Doherty CA, Laird DJ 2025-05-01
Mammalian oocytes receive maternal-effect RNAs from granulosa cells.
Doherty CA, Tijjani A, Munger SC, Laird DJ 2025-02-11
An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology.
Sokolowski DJ, Miclau? M, Nater A, Faykoo-Martinez M, Hoekzema K, Zuzarte P, Monis S, Alvi SA, Erdmann J, Erdmann AL, Kumaragurubaran R, Bayerl J, Yoo D, Karimpour N, Ungerleider K, Hou H, J Martin F, Hourlier T, Clarke Z, Lischer HEL, Leordean DV, Jiang Y, Pugh TJ, Smith ESJ, Haggerty L, Laird DJ, Lilue J, Holmes MM, Eichler EE, Bruggmann R, Simpson JT, Balmus G, Wilson MD 2024-11-28
Sustained fertility from first-wave follicle oocytes that pause their growth.
Soygur B, Gaylord EA, Foecke MH, Cincotta SA, Horan TS, Wood A, Cohen PE, Laird DJ 2024-08-28
Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.
Borges B, Varthaliti A, Schwab M, Clarke MT, Pivetti C, Gupta N, Cadwell CR, Guibinga G, Phillips S, Del Rio T, Ozsolak F, Imai-Leonard D, Kong L, Laird DJ, Herzeg A, Sumner CJ, MacKenzie TC 2024-05-04
Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions.
Prasasya RD, Caldwell BA, Liu Z, Wu S, Leu NA, Fowler JM, Cincotta SA, Laird DJ, Kohli RM, Bartolomei MS 2024-04-02
Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
Cincotta SA, Richardson N, Foecke MH, Laird DJ 2024-01-16
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells.
Gökbuget D, Lenshoek K, Boileau RM, Bayerl J, Huang H, Wiita AP, Laird DJ, Blelloch R 2023-09-11
Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.
Samuel RM, Navickas A, Maynard A, Gaylord EA, Garcia K, Bhat S, Majd H, Richter MN, Elder N, Le D, Nguyen P, Shibata B, Llabata ML, Selleri L, Laird DJ, Darmanis S, Goodarzi H, Fattahi F 2023-03-07
Eggs made from male mouse stem cells using error-prone culture.
Bayerl J, Laird DJ 2023-03-01
Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats.
Brieño-Enríquez MA, Faykoo-Martinez M, Goben M, Grenier JK, McGrath A, Prado AM, Sinopoli J, Wagner K, Walsh PT, Lopa SH, Laird DJ, Cohen PE, Wilson MD, Holmes MM, Place NJ 2023-02-21
A Roadmap for Three-Dimensional Analysis of the Intact Mouse Ovary.
Soygur B, Foecke MH, Gaylord EA, Fries A, Li J, Arora R, Laird DJ 2023-01-01
Ovary Development: Insights From a Three-Dimensional Imaging Revolution.
Soygur B, Laird DJ 2021-07-26
Natural selection at the cellular level: insights from male germ cell differentiation.
Nguyen DH, Laird DJ 2021-06-02
Intercellular bridges coordinate the transition from pluripotency to meiosis in mouse fetal oocytes.
Soygur B, Jaszczak RG, Fries A, Nguyen DH, Malki S, Hu G, Demir N, Arora R, Laird DJ 2021-04-07
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones.
Nguyen DH, Soygur B, Peng SP, Malki S, Hu G, Laird DJ 2020-11-16
The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community.
Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ 2020-05-04
Maternal vitamin C regulates reprogramming of DNA methylation and germline development.
DiTroia SP, Percharde M, Guerquin MJ, Wall E, Collignon E, Ebata KT, Mesh K, Mahesula S, Agathocleous M, Laird DJ, Livera G, Ramalho-Santos M 2019-09-04
Heterogeneity of primordial germ cells.
Nguyen DH, Jaszczak RG, Laird DJ 2019-05-14
Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells.
Reznik B, Cincotta SA, Jaszczak RG, Mateo LJ, Shen J, Cao M, Baskin L, Ye P, An W, Laird DJ 2019-02-01
How to lose your inheritance.
Laird DJ 2018-10-01
Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.
Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH 2017-09-08
A pilgrim's progress: Seeking meaning in primordial germ cell migration.
Cantú AV, Laird DJ 2017-07-18
Smad4 regulates growth plate matrix production and chondrocyte polarity.
Whitaker AT, Berthet E, Cantu A, Laird DJ, Alliston T 2017-03-15
Patterning of sharp cellular interfaces with a reconfigurable elastic substrate.
Curtis A, Li DJ, DeVeale B, Onishi K, Kim MY, Blelloch R, Laird DJ, Hui EE 2017-01-23
Insights from imaging the implanting embryo and the uterine environment in three dimensions.
Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice LC, Laird DJ 2016-11-11
ROR2 in the adult mouse testis.
Arora R, Laird DJ 2016-11-01
Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling.
Cantú AV, Altshuler-Keylin S, Laird DJ 2016-07-11
Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary.
Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ 2016-05-19
A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates.
Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH 2016-05-17
DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
Sousa Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M 2016-01-29
Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity.
Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice LC 2015-10-26
Follicle dynamics and global organization in the intact mouse ovary.
Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ 2015-04-16
Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system.
Arora R, Altman E, Tran ND, Laird DJ 2014-05-06
Wnt and Bmp fit germ cells to a T.
Cantú AV, Laird DJ 2013-12-09
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M 2013-06-30
Humans put their eggs in more than one basket.
Laird DJ 2013-01-01
Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.
Chen L, Faire M, Kissner MD, Laird DJ 2012-10-16
miR-372/let-7 axis regulates human primordial germ cell specification.
N.D. Tran, M. Kissner, D. Laird, R. Blelloch 2012-09-01
UCSF Research Profile
Ror2 enhances polarity and directional migration of primordial germ cells.
Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV 2011-12-22
Lin28-let7-Blimp1 Circuitry regulates human primordial germ cells (hPGC) development from human embryonic stem cells (hESC).
N.D. Tran, D. Laird, M. Kissner, M. Conti, R. Blelloch 2011-09-01
UCSF Research Profile
Establishment and characterization of human germ cells derived from embryonic stem cells (hESCs).
N.D. Tran, D. Laird, M. Kissner, D. Supramanyam, M. Conti, R. Blelloch 2010-09-01
UCSF Research Profile
Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H 2010-08-25
Stem cell trafficking in tissue development, growth, and disease.
Laird DJ, von Andrian UH, Wagers AJ 2008-02-22
Stem cells are units of natural selection in a colonial ascidian.
Laird DJ, De Tomaso AW, Weissman IL 2005-12-29
Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri.
Laird DJ, Chang WT, Weissman IL, Lauzon RJ 2005-12-01
Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri.
Laird DJ, De Tomaso AW 2005-01-01
Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri.
Laird DJ, Weissman IL 2004-09-15
Continuous development precludes radioprotection in a colonial ascidian.
Laird DJ, Weissman IL 2004-03-01
50 million years of chordate evolution: seeking the origins of adaptive immunity.
Laird DJ, De Tomaso AW, Cooper MD, Weissman IL 2000-06-20
PubMed