Biography
In her research, Feng studies transplantation tolerance, a transplant recipient's ability to maintain normal organ function with minimal or no use of immunosuppressive drugs. With funding from the National Institutes of Health, she has led several multicenter clinical trials to study tolerance in both adult and pediatric liver transplant recipients.
Feng is a graduate of Harvard College, where she received the prestigious Marshall Scholarship. She completed a doctorate in molecular biology at the University of Cambridge and earned her medical degree at Stanford University School of Medicine. She completed a general surgery residency at Brigham and Women's Hospital, followed by a transplant fellowship at UCSF.
Feng has held leadership positions in prominent professional societies and with the United Network for Organ Sharing. She has organized several national conferences addressing issues critical to the transplantation community, serves on the editorial board of the New England Journal of Medicine and is the editor-in-chief for the American Journal of Transplantation.
Dr. Feng was elected to be a member of the National Academy of Medicine in 2023.
Videos
Education
| Institution | Degree | Dept or School | End Date | 
|---|---|---|---|
| University of California | Diversity, Equity, and Inclusion Champion Training | 12/2020 | |
| Stanford University | M.D. | School of Medicine | 1990 | 
Board Certifications
American Board of Surgery, 1996
Collaboration Interests
I am interested in:
- physician scientist
Clinical Expertise
Expanded Criteria Donor Kidney Transplantation
Immunosuppression for Liver Transplantation
Kidney Transplantation
Liver Transplantation
MELD Allocation and Living Donor Liver Transplantation
Pancreas Transplantation
Clinical Trials
- EVR and EPO for Liver Transplant Tolerance (NCT06832189)Related Conditions: Liver Transplant| Start Date: | End Date:
- Related Conditions: Liver Transplant| Start Date: | End Date:
- Liver Transplantation With Tregs at UCSF (NCT03654040)Related Conditions: Liver Transplant| Start Date: | End Date:
- Related Conditions: Liver Transplant| Start Date: | End Date:
- Related Conditions: Liver Transplant| Start Date: | End Date:
- Related Conditions: Liver Transplant| Start Date: | End Date:
Program Affiliations
- Clinical Fellowship, Division of Transplantation
- The Liver Center at UCSF
- Director, Expanded Criteria Donor Kidney Transplant Program, University of California, San Francisco
- UCSF Hellen Diller Family Comprehensive Cancer Center
In the News
Grants and Funding
- PROSPECTIVE LONGITUDINAL STUDY OF IWITH SCREEN FAILURES SECONDARY TO HISTOPATHOLOGY | NIH | 2017-08-10 - 2021-07-31 | Role: Principal Investigator
- Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation | NIH | 2014-06-01 - 2021-05-31 | Role: Principal Investigator
- Polyclonal Tregs to Promote Tolerance in Pediatric Liver Transplant Recipients | NIH | 2013-02-01 - 2020-01-31 | Role: Principal Investigator
- Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients | NIH | 2012-07-27 - 2019-06-30 | Role: Principal Investigator
- Donor-Specific Regulatory T Cell Therapy in Liver Transplantation | NIH | 2012-04-01 - 2014-03-31 | Role: Principal Investigator
- Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients | NIH | 2009-09-30 - 2013-03-31 | Role: Principal Investigator
Research Narrative
Dr. Feng's research interest focuses on transplant immunology, with a particular focus on determinants of organ tolerance. She is also investigating novel immunosuppressive regimens and pursuing immunosuppression withdrawal in selected liver transplant recipients. By studying the immune profiles of transplant patients who are successfully weaned from immunosuppressants, she and her group hope to predict prospectively which patients may be good candidates for immunosuppression withdrawal.
Research Interests
- Immunosuppression Withdrawal for Stable Pediatric Living Donor Liver Transplant Recipients
- Immunosuppression Withdrawal and Identification of a Profile Predictive of Tolerance
- Defining the Optimal Immunosuppression for Specific Transplant Settings
- Expanded Criteria Donors
- Novel Immunosuppression Strategies for Liver Transplantation
- Strategies to Decrease Ischemia Reperfusion Injury to Improve Early Graft Function after Kidney Transplantation
- Improving Long-term Outcomes for Liver Transplant Recipients
Publications
- Trends and Recipient Outcomes in Multiorgan Transplantation in the United States 2013-2023.| | PubMed PubMed
- The Cirrhosis-Hospital Frailty Risk Score predicts mortality in patients with chronic liver disease: Analysis of a nationally representative database.| | PubMed PubMed
- Xenotransplantation - Long Awaited, Much Learned, Much More to Be Learned.| | PubMed PubMed
- Efficacy of Steroid Pulse to Treat Borderline T-Cell Mediated Rejection on Protocol Kidney Allograft Biopsy.| | PubMed PubMed
- Clinical Practice Recommendations on the Effect of COVID-19 Vaccination Strategies on Outcomes in Solid Organ Transplant Recipients.| | PubMed PubMed
- Defining an NK Cell-enriched Rejection-like Phenotype in Liver Transplant Biopsies From the INTERLIVER Study.| | PubMed PubMed
- Donor-specific immune senescence as a candidate biomarker of operational tolerance following liver transplantation in adults: Results of a prospective, multicenter cohort study.| | PubMed PubMed
- Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights.| | PubMed PubMed
- The type, duration, and severity of pretransplant kidney injury predict prolonged kidney dysfunction after liver transplantation.| | PubMed PubMed
- The future of liver transplantation.| | PubMed PubMed
- Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health.| | PubMed PubMed
- The Banff process-Reloaded: A joint initiative from the Banff Foundation for Allograft Pathology and the American Journal of Transplantation.| | PubMed PubMed
- A modified Hospital Frailty Risk Score for patients with cirrhosis undergoing abdominal operations.| | PubMed PubMed
- Advancing mouse models for transplantation research.| | PubMed PubMed
- Transforming the Future of Surgeon-Scientists.| | PubMed PubMed
- Time since liver transplant and immunosuppression withdrawal outcomes: Systematic review and individual patient data meta-analysis.| | PubMed PubMed
- Kidney transplantation in a patient with anomalous iliofemoral vasculature.| | PubMed PubMed
- DCD liver transplant in patients with a MELD over 35.| | PubMed PubMed
- Mapping children by ALT 4-5 years after liver transplant: Potential individual and population applications.| | PubMed PubMed
- Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.| | PubMed PubMed
- Real-world implementation of normothermic machine perfusion: A detailed analysis of intraoperative and early postoperative impact.| | PubMed PubMed
- Liver transplantation immunology: Immunosuppression, rejection, and immunomodulation.| | PubMed PubMed
- Supporting Robust Teamwork - Bridging Technology and Organizational Science.| | PubMed PubMed
- Immunosuppression after pediatric liver transplant: The parents' perspective.| | PubMed PubMed
- Addressing sex-based disparities in solid organ transplantation in the United States - a conference report.| | PubMed PubMed
- Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.| | PubMed PubMed
- Next-generation pathology detection of T cell-antigen-presenting cell immune synapses in human liver allografts.| | PubMed PubMed
- Standardizing the histological assessment of late posttransplantation biopsies from pediatric liver allograft recipients.| | PubMed PubMed
- Transcriptomic profiling of blood from autoimmune hepatitis patients reveals potential mechanisms with implications for management.| | PubMed PubMed
- Graft Fibrosis Over 10 to 15 Years in Pediatric Liver Transplant Recipients: Multicenter Study of Paired, Longitudinal Surveillance Biopsies.| | PubMed PubMed
- We Asked the Experts: Toward Personalized Immunosuppression for Liver Transplant Recipients.| | PubMed PubMed
- Not everything that counts can be counted: Tracking long-term outcomes in pediatric liver transplant recipients.| | PubMed PubMed
- Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.| | PubMed PubMed
- Impact of Donor and Recipient Clinical Characteristics and Hepatic Histology on Steatosis/Fibrosis Following Liver Transplantation.| | PubMed PubMed
- Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study.| | PubMed PubMed
- The molecular phenotypes of injury, steatohepatitis, and fibrosis in liver transplant biopsies in the INTERLIVER study.| | PubMed PubMed
- Baby Steps: Understanding Allograft Fibrosis in Pediatric Liver Transplantation.| | PubMed PubMed
- Non-invasive alloimmune risk stratification of long-term liver transplant recipients.| | PubMed PubMed
- Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management.| | PubMed PubMed
- Improvements in Disease-Specific Health-Related Quality of Life of Pediatric Liver Transplant Recipients During Immunosuppression Withdrawal.| | PubMed PubMed
- Transplantation From Older Donors: Can Senolytics Turn Back the Clock?| | PubMed PubMed
- COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions.| | PubMed PubMed
- A Virtual Crossmatch-based Strategy Facilitates Sharing of Deceased Donor Kidneys for Highly Sensitized Recipients.| | PubMed PubMed
- Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report.| | PubMed PubMed
- Rapid Modification of Workflows and Fellow Staffing at a Single Transplant Center to Address the COVID-19 Crisis.| | PubMed PubMed
- Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group.| | PubMed PubMed
- The molecular diagnosis of rejection in liver transplant biopsies: First results of the INTERLIVER study.| | PubMed PubMed
- Long-term follow-up of beta cell replacement therapy in 10 HIV-infected patients with renal failure secondary to type 1 diabetes mellitus.| | PubMed PubMed
- IgG4 donor-specific HLA antibody profile is associated with subclinical rejection in stable pediatric liver recipients.| | PubMed PubMed
- Prevalence and Impact of De Novo Donor-Specific Antibodies During a Multicenter Immunosuppression Withdrawal Trial in Adult Liver Transplant Recipients.| | PubMed PubMed
- Posttransplant biopsy risk for stable long-term pediatric liver transplant recipients: 451 percutaneous biopsies from two multicenter immunosuppression withdrawal trials.| | PubMed PubMed
- Outcomes of immunosuppression minimization and withdrawal early after liver transplantation.| | PubMed PubMed
- Reply.| | PubMed PubMed
- Liver transplants for noncitizens/nonresidents: What is the problem, and what should be done?| | PubMed PubMed
- Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants.| | PubMed PubMed
- Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.| | PubMed PubMed
- Reply.| | PubMed PubMed
- Physical frailty after liver transplantation.| | PubMed PubMed
- The Liver Frailty Index Improves Mortality Prediction of the Subjective Clinician Assessment in Patients With Cirrhosis.| | PubMed PubMed
- Tolerance after liver transplantation: Where are we?| | PubMed PubMed
- Tolerance in clinical liver transplantation.| | PubMed PubMed
- Living donor liver transplantation in high Model for End-Stage Liver Disease score patients.| | PubMed PubMed
- Early and Late Factors Impacting Patient and Graft Outcome in Pediatric Liver Transplantation: Summary of an ESPGHAN Monothematic Conference.| | PubMed PubMed
- Development of a novel frailty index to predict mortality in patients with end-stage liver disease.| | PubMed PubMed
- Optimizing Graft Survival by Pretreatment of the Donor.| | PubMed PubMed
- Current status of tolerance in kidney transplantation.| | PubMed PubMed
- The questions not the answers: Outcomes after pediatric liver transplantation.| | PubMed PubMed
- A Comparison of Muscle Function, Mass, and Quality in Liver Transplant Candidates: Results From the Functional Assessment in Liver Transplantation Study.| | PubMed PubMed
- Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R.| | PubMed PubMed
- Response to clinical assessments of health status as a potential marker to identify patients who are too sick to undergo transplantation.| | PubMed PubMed
- Spontaneous and induced tolerance for liver transplant recipients.| | PubMed PubMed
- Functional decline in patients with cirrhosis awaiting liver transplantation: Results from the functional assessment in liver transplantation (FrAILT) study.| | PubMed PubMed
- Functional impairment in older liver transplantation candidates: From the functional assessment in liver transplantation study.| | PubMed PubMed
- Peripheral phenotype and gene expression profiles of combined liver-kidney transplant patients.| | PubMed PubMed
- The corrected donor age for hepatitis C virus-infected liver transplant recipients.| | PubMed PubMed
- Clinician assessments of health status predict mortality in patients with end-stage liver disease awaiting liver transplantation.| | PubMed PubMed
- Renal outcomes of simultaneous liver-kidney transplantation compared to liver transplant alone for candidates with renal dysfunction.| | PubMed PubMed
- Combined effects of recipient age and model for end-stage liver disease score on liver transplantation outcomes.| | PubMed PubMed
- Expanded criteria donors.| | PubMed PubMed
- Multiple listings as a reflection of geographic disparity in liver transplantation.| | PubMed PubMed
- Evaluation for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation.| | PubMed PubMed
- Donor Risk Index for African American liver transplant recipients with hepatitis C virus.| | PubMed PubMed
- Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation.| | PubMed PubMed
- Offer patterns of nationally placed livers by donation service area.| | PubMed PubMed
- An examination of liver offers to candidates on the liver transplant wait-list.| | PubMed PubMed
- Increasing disparity in waitlist mortality rates with increased model for end-stage liver disease scores for candidates with hepatocellular carcinoma versus candidates without hepatocellular carcinoma.| | PubMed PubMed
- Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants.| | PubMed PubMed
- KIR genotypic diversity can track ancestries in heterogeneous populations: a potential confounder for disease association studies.| | PubMed PubMed
- Kidney transplant performed after liver transplant: a single center experience.| | PubMed PubMed
- Preface: Optimization of outcomes for children after solid organ transplantation.| | PubMed PubMed
- Tolerance: is it achievable in pediatric solid organ transplantation?| | PubMed PubMed
- Management of the liver transplant patient.| | PubMed PubMed
- Factors influencing liver transplant length of stay at two large-volume transplant centers.| | PubMed PubMed
- Report of the first international liver transplantation society expert panel consensus conference on renal insufficiency in liver transplantation.| | PubMed PubMed
- Increased donor risk: who should bear the burden?| | PubMed PubMed
- Long-term histological effects of preemptive antiviral therapy in liver transplant recipients with hepatitis C virus infection.| | PubMed PubMed
- Long-term management of immunosuppression after pediatric liver transplantation: is minimization or withdrawal desirable or possible or both?| | PubMed PubMed
- Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis.| | PubMed PubMed
- Steatotic livers for liver transplantation--life-saving but at a cost.| | PubMed PubMed
- Allocation policy for hepatocellular carcinoma in the MELD era: room for improvement?| | PubMed PubMed
- Linking the US transplant registry to administrative claims data: expanding the potential of transplant research.| | PubMed PubMed
- Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy.| | PubMed PubMed
- In a MELD-based economy, how can we fight off inflation?| | PubMed PubMed
- Optimizing living donor kidney graft function by donor-recipient pair selection.| | PubMed PubMed
- Magnetic resonance imaging of hepatocellular carcinoma mimicking focal nodular hyperplasia: a potential pitfall in patients with cirrhosis?| | PubMed PubMed
- How can we define expanded criteria for liver donors?| | PubMed PubMed
- Effect of mycophenolate mofetil on rat kidney grafts with prolonged cold preservation.| | PubMed PubMed
- Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.| | PubMed PubMed
- Trends over a decade of pediatric liver transplantation in the United States.| | PubMed PubMed
- A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation.| | PubMed PubMed
- End stage polycystic kidney disease: indications and timing of native nephrectomy relative to kidney transplantation.| | PubMed PubMed
- Expanded criteria donor kidney allocation: marked decrease in cold ischemia and delayed graft function at a single center.| | PubMed PubMed
- Selecting livers for transplantation: can beggars be choosers?| | PubMed PubMed
- PELD: working well, but only half of the time?| | PubMed PubMed
- Laparoscopic procurement of kidneys with multiple renal arteries is associated with increased ureteral complications in the recipient.| | PubMed PubMed
- Impact of sirolimus on early graft function after deceased-donor kidney transplantation.| | PubMed PubMed
- An older liver in the hand, or a (possibly) younger liver in the bush?| | PubMed PubMed
- Surgical challenges in transplantation: the Fourth Annual American Society of Transplant Surgeons' State-of-the-Art Winter Symposium.| | PubMed PubMed
- BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant.| | PubMed PubMed
- Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors.| | PubMed PubMed
- Increased rejection in living unrelated versus living related kidney transplants does not affect short-term function and survival.| | PubMed PubMed
- Developmental context determines latency of MYC-induced tumorigenesis.| | PubMed PubMed
- Comparison of outcomes after delayed graft function: sirolimus-based versus other calcineurin-inhibitor sparing induction immunosuppression regimens.| | PubMed PubMed
- Hepatitis C etiology of liver disease is strongly associated with early acute rejection following liver transplantation.| | PubMed PubMed
- National conference to assess antibody-mediated rejection in solid organ transplantation.| | PubMed PubMed
- Early graft function after living donor kidney transplantation predicts rejection but not outcomes.| | PubMed PubMed
- An uncomfortable silence em leader while we all search for a better reporter gene in adult stem cell biology.| | PubMed PubMed
- Organ donors with malignant gliomas: an update.| | PubMed PubMed
- Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury.| | PubMed PubMed
- Tumors and transplantation: The 2003 Third Annual ASTS State-of-the-Art Winter Symposium.| | PubMed PubMed
- Death from donor-transmitted malignancy despite emergency liver retransplantation.| | PubMed PubMed
- Excellent short-term results with steroid-free maintenance immunosuppression in low-risk simultaneous pancreas-kidney transplantation.| | PubMed PubMed
- Management of lymphoceles after renal transplantation: laparoscopic versus open drainage.| | PubMed PubMed
- Sirolimus prolongs recovery from delayed graft function after cadaveric renal transplantation.| | PubMed PubMed
- Expanded criteria donors for kidney transplantation.| | PubMed PubMed
- Organ donors with positive viral serology or malignancy: risk of disease transmission by transplantation.| | PubMed PubMed
- Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donor.| | PubMed PubMed
- Targeted gene therapy with CD40Ig to induce long-term acceptance of liver allografts.| | PubMed PubMed
- HIV-1 tat trans-activation requires the loop sequence within tar.| | PubMed PubMed
 
     
