Education
| Institution | Degree | Dept or School | End Date |
|---|---|---|---|
| University of California | Diversity, Equity, and Inclusion Champion Training | 2021 | |
| UCSF | Fellowship | Diabetes, Endocrinology, and Metabolism | 06/2006 |
| Baylor College of Medicine | Residency | Internal Medicine/Pediatrics | 06/2003 |
| Baylor College of Medicine | M.D. | Medicine | 05/1999 |
| Baylor College of Medicine | Ph.D. | Molecular Physiology | 05/1995 |
| University of California Los Angeles | B.S. | Psychobiology | 06/1992 |
Awards & Honors
| Award | Conferred By | Date |
|---|---|---|
| Guenther Boden, MD Memorial Award Lecture | Temple University School of Medicine | 2024 |
| Distinguished Endocrinologist Award Lecture | University of California Irvine | 2022 |
| Election to American Society of Clinical Investigation | American Society for Clinical Investigation (ASCI) | 2018 |
| Outstanding Postdoctoral Researcher | J. David Gladstone Institutes | 2011 |
| A.P. Giannini Scholarship In Medical Research | UCSF and J. David Gladstone Institutes | 2006 |
| Outstanding Resident Teaching Award | Baylor College of Medicine | 1999 |
| Alpha Omega Alpha Medical Honor Society | Baylor College of Medicine | 1998 |
Collaboration Interests
I am interested in:
- physician scientist
Grants and Funding
- Immunologic and Fat-Associated Predictors of Insulin Resistance in Treated HIV | NIH/NIDDK | 2017-07-20 - 2022-04-30 | Role: Co-Principal Investigator
- Immunologic and Fat-Associated Predictors of Insulin Resistance in Treated HIV | NIH | 2017-07-20 - 2022-04-30 | Role: Principal Investigator
- Microglia: dietary fat-sensitive mediators of inflammation and metabolic disease | NIH | 2015-03-01 - 2021-02-28 | Role: Principal Investigator
- Myeloid-specific Triacylglycerol Storage in Inflammation and Metabolic Disease | NIH | 2013-03-01 - 2015-02-28 | Role: Principal Investigator
- DGAT1: Linking Fatty Acids to Inflammation and Metabolism in White Adipose Tissue | NIH | 2009-04-01 - 2014-03-31 | Role: Principal Investigator
Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 87
- Assessment of Large Language Models for Enhancing Diabetologist-Developed Personalized Treatment Plans in Complex Type 2 Diabetes.| | UCSF Research Profile
- Phenome-Wide Risk Evaluation of GLP-1 Receptor Agonist Use in Type 2 Diabetes with Real-World Data Across Multiple Healthcare Systems.| |
PubMed
- Novel Inpatient Automated Self-Adjusting Subcutaneous Insulin Algorithm: Three-Year Experience. An observational study.| |
PubMed
- A Distinct Form of Subcutaneous Fat Fibrosis Predicts Insulin Resistance in People with HIV.| |
PubMed
- Real-World Type 2 Diabetes Second-Line Treatment Allocation Among Patients.| |
PubMed
- Q&A with Suneil Koliwad and Martin Valdearcos.| |
PubMed
- Microglia mediate the early-life programming of adult glucose control.| |
PubMed
- Consensus on the key characteristics of metabolism disruptors.| |
PubMed
- The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.| |
PubMed
- 8154 The Pro-Fibrotic Transcriptional Profile of Adipose Tissue in Insulin Resistant Individuals.| | UCSF Research Profile
- Microglia mediate the early-life programming of adult glucose control.| |
PubMed
- 1879-LB: Automated Self-Adjusting Subcutaneous Insulin Algorithm (SQIA) Improves Glycemic Control in Hospitalized Patients—Three-Year Experience.| | UCSF Research Profile
- Novel Automated Self-adjusting Subcutaneous Insulin Algorithm Improves Glycemic Control and Physician Efficiency in Hospitalized Patients.| |
PubMed
- PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.| |
PubMed
- Second-Line Pharmaceutical Treatments for Patients with Type 2 Diabetes.| |
PubMed
- Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance.| |
PubMed
- Twenty-first century management of diabetes with shared telemedicine appointments.| |
PubMed
- MFGE8 inhibits insulin signaling through PTP1B.| |
PubMed
- Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a Healthy Environment and Endocrine Disruptors Strategies Workshop.| |
PubMed
- 407 Moving from observational studies to a clinical trial: the impact of obesity and surgical weight loss on breast imaging, tissue, and cancer screening experience: the B-BRITE study.| | UCSF Research Profile
- The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma.| |
PubMed
- Excess natural-cause deaths in California by cause and setting: March 2020 through February 2021.| |
PubMed
- ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis.| |
PubMed
- Metabolic factors in the regulation of hypothalamic innate immune responses in obesity.| |
PubMed
- A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings.| |
PubMed
- A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.| |
PubMed
- Reducing Methylglyoxal Rescues Obesity Related Phenotypes and Lifespan in a Leptin Receptor Deficient Mouse Model.| | UCSF Research Profile
- Reducing Methylglyoxal Rescues Obesity Related Phenotypes and Lifespan in a Leptin Receptor Deficient Mouse Model.| | UCSF Research Profile
- The relationship between physical activity intensity and volume on prospective falls in older adults.| | UCSF Research Profile
- Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems.| |
PubMed
- The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health.| |
PubMed
- Continuous Ketone Monitoring Consensus Report 2021.| |
PubMed
- Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis.| |
PubMed
- Invariant Natural Killer T cells coordinate removal of senescent cells.| |
PubMed
- Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.| |
PubMed
- Lack of association between either outpatient or inpatient glycemic control and COVID-19 illness severity or mortality in patients with diabetes.| |
PubMed
- Continuous Ketone Monitoring: A New Paradigm for Physiologic Monitoring.| |
PubMed
- Quantifying Variation in Treatment Utilization for Type 2 Diabetes Across Five Major University of California Health Systems.| |
PubMed
- Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.| |
PubMed
- CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.| |
PubMed
- 1769-P: Microglial Activation and Inactivation via Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) Alters Peripheral Glucose Homeostasis.| | UCSF Research Profile
- Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking.| |
PubMed
- Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.| |
PubMed
- Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications.| |
PubMed
- mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.| |
PubMed
- Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status.| |
PubMed
- Hypothalamic microglia as potential regulators of metabolic physiology.| |
PubMed
- Fighting obesity by targeting factors regulating beige adipocytes.| |
PubMed
- Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.| |
PubMed
- Progranulin in the hematopoietic compartment protects mice from atherosclerosis.| |
PubMed
- Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.| |
PubMed
- Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.| |
PubMed
- Microglia Activation Regulates Systemic Glucose Tolerance.| | UCSF Research Profile
- Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice.| |
PubMed
- Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis.| |
PubMed
- Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.| |
PubMed
- The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure.| |
PubMed
- Digital Diabetes Congress 2017.| |
PubMed
- Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.| |
PubMed
- Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.| |
PubMed
- Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.| |
PubMed
- Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.| |
PubMed
- GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance.| |
PubMed
- The Electronic CardioMetabolic Program (eCMP) for Patients With Cardiometabolic Risk: A Randomized Controlled Trial.| |
PubMed
- Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice.| |
PubMed
- Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells.| |
PubMed
- Leptin potentiates astrogenesis in the developing hypothalamus.| |
PubMed
- Hypothalamic inflammation in the control of metabolic function.| |
PubMed
- Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.| |
PubMed
- A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.| |
PubMed
- Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein.| |
PubMed
- Angiopoietin-like 4 (Angptl4): A glucocorticoid-dependent gatekeeper of fatty acid flux during fasting.| |
PubMed
- Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.| | UCSF Research Profile
- Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.| |
PubMed
- Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.| |
PubMed
- DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.| | UCSF Research Profile
- DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.| |
PubMed
- Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.| |
PubMed
- Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.| |
PubMed
- Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.| |
PubMed
- Increased longevity in mice lacking DGAT1.| | UCSF Research Profile
- 4 Redox Regulation of Ion Channels.| | UCSF Research Profile
- Analysis of a Ca2+-activated K+ channel that mediates hyperpolarization via the thrombin receptor pathway.| |
PubMed
- Redox control of ion channel activity in vascular endothelial cells by glutathione.| |
PubMed
- Oxidized glutathione mediates cation channel activation in calf vascular endothelial cells during oxidant stress.| |
PubMed
- Oxidant stress activates a non-selective cation channel responsible for membrane depolarization in calf vascular endothelial cells.| |
PubMed
- Oxidant stress and endothelial membrane transport.| |
PubMed