University of California San Francisco

Ryan Corces, PhD

ryan.corces
Ryan Corces, PhD

Assistant Professor, Neurology
School of Medicine

Address

35 Medical Center Way, #501
San Francisco, CA 94143
United States

ORCID: 0000-0001-7465-7652

Education

Institution Degree Dept or School End Date
Stanford University PostDoc Epigenetics, Neurobiology 06/2020
Stanford University PhD Cancer Biology 10/2015
Princeton University AB Molecular Biology 06/2008

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 29
  1. CHOIR improves significance-based detection of cell types and states from single-cell data.
    Sant C, Mucke L, Corces MR| | PubMed
  2. Decoding polygenic diseases: advances in noncoding variant prioritization and validation.
    Chin IM, Gardell ZA, Corces MR| | PubMed
  3. Chromatin accessibility profiling by ATAC-seq.
    Grandi FC, Modi H, Kampman L, Corces MR| | PubMed
  4. Single-cell mutational profiling enhances the clinical evaluation of AML MRD.
    Ediriwickrema A, Aleshin A, Reiter JG, Corces MR, Köhnke T, Stafford M, Liedtke M, Medeiros BC, Majeti R| | PubMed
  5. Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia.
    Granja JM, Klemm S, McGinnis LM, Kathiria AS, Mezger A, Corces MR, Parks B, Gars E, Liedtke M, Zheng GXY, Chang HY, Majeti R, Greenleaf WJ| | PubMed
  6. Circular ecDNA promotes accessible chromatin and high oncogene expression.
    Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS| | PubMed
  7. Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion.
    Satpathy AT, Granja JM, Yost KE, Qi Y, Meschi F, McDermott GP, Olsen BN, Mumbach MR, Pierce SE, Corces MR, Shah P, Bell JC, Jhutty D, Nemec CM, Wang J, Wang L, Yin Y, Giresi PG, Chang ALS, Zheng GXY, Greenleaf WJ, Chang HY| | PubMed
  8. HiChIRP reveals RNA-associated chromosome conformation.
    Mumbach MR, Granja JM, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH, Guo JK, Gennert DG, Corces MR, Khavari PA, Atianand MK, Artandi SE, Fitzgerald KA, Greenleaf WJ, Chang HY| | PubMed
  9. Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA.
    Xu J, Nuno K, Litzenburger UM, Qi Y, Corces MR, Majeti R, Chang HY| | PubMed
  10. The chromatin accessibility landscape of primary human cancers.
    Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC, Groeneveld C, Wong CK, Cho SW, Satpathy AT, Mumbach MR, Hoadley KA, Robertson AG, Sheffield NC, Felau I, Castro MAA, Berman BP, Staudt LM, Zenklusen JC, Laird PW, Curtis C, Cancer Genome Atlas Analysis Network, Greenleaf WJ, Chang HY| | PubMed
  11. Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation.
    Buenrostro JD, Corces MR, Lareau CA, Wu B, Schep AN, Aryee MJ, Majeti R, Chang HY, Greenleaf WJ| | PubMed
  12. Transcript-indexed ATAC-seq for precision immune profiling.
    Satpathy AT, Saligrama N, Buenrostro JD, Wei Y, Wu B, Rubin AJ, Granja JM, Lareau CA, Li R, Qi Y, Parker KR, Mumbach MR, Serratelli WS, Gennert DG, Schep AN, Corces MR, Khodadoust MS, Kim YH, Khavari PA, Greenleaf WJ, Davis MM, Chang HY| | PubMed
  13. Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia.
    Corces MR, Chang HY, Majeti R| | PubMed
  14. Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons.
    Wapinski OL, Lee QY, Chen AC, Li R, Corces MR, Ang CE, Treutlein B, Xiang C, Baubet V, Suchy FP, Sankar V, Sim S, Quake SR, Dahmane N, Wernig M, Chang HY| | PubMed
  15. Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.
    Mumbach MR, Satpathy AT, Boyle EA, Dai C, Gowen BG, Cho SW, Nguyen ML, Rubin AJ, Granja JM, Kazane KR, Wei Y, Nguyen T, Greenside PG, Corces MR, Tycko J, Simeonov DR, Suliman N, Li R, Xu J, Flynn RA, Kundaje A, Khavari PA, Marson A, Corn JE, Quertermous T, Greenleaf WJ, Chang HY| | PubMed
  16. An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues.
    Corces MR, Trevino AE, Hamilton EG, Greenside PG, Sinnott-Armstrong NA, Vesuna S, Satpathy AT, Rubin AJ, Montine KS, Wu B, Kathiria A, Cho SW, Mumbach MR, Carter AC, Kasowski M, Orloff LA, Risca VI, Kundaje A, Khavari PA, Montine TJ, Greenleaf WJ, Chang HY| | PubMed
  17. Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist.
    McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, Majeti R| | PubMed
  18. Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.
    Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R| | PubMed
  19. Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution.
    Corces MR, Buenrostro JD, Wu B, Greenside PG, Chan SM, Koenig JL, Snyder MP, Pritchard JK, Kundaje A, Greenleaf WJ, Majeti R, Chang HY| | PubMed
  20. A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells.
    Reinisch A, Thomas D, Corces MR, Zhang X, Gratzinger D, Hong WJ, Schallmoser K, Strunk D, Majeti R| | PubMed
  21. The three-dimensional cancer genome.
    Corces MR, Corces VG| | PubMed
  22. Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.
    Mazumdar C, Shen Y, Xavy S, Zhao F, Reinisch A, Li R, Corces MR, Flynn RA, Buenrostro JD, Chan SM, Thomas D, Koenig JL, Hong WJ, Chang HY, Majeti R| | PubMed
  23. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia.
    Chan SM, Thomas D, Corces-Zimmerman MR, Xavy S, Rastogi S, Hong WJ, Zhao F, Medeiros BC, Tyvoll DA, Majeti R| | PubMed
  24. Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.
    Sinha S, Thomas D, Yu L, Gentles AJ, Jung N, Corces-Zimmerman MR, Chan SM, Reinisch A, Feinberg AP, Dill DL, Majeti R| | PubMed
  25. Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis.
    Corces-Zimmerman MR, Majeti R| | PubMed
  26. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission.
    Corces-Zimmerman MR, Hong WJ, Weissman IL, Medeiros BC, Majeti R| | PubMed
  27. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.
    Jan M, Snyder TM, Corces-Zimmerman MR, Vyas P, Weissman IL, Quake SR, Majeti R| | PubMed
  28. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.
    Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, Lajoie BR, Protacio A, Flynn RA, Gupta RA, Wysocka J, Lei M, Dekker J, Helms JA, Chang HY| | PubMed
  29. Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.
    Kauffman AL, Ashraf JM, Corces-Zimmerman MR, Landis JN, Murphy CT| | PubMed