University of California San Francisco

Richard Locksley, MD
Richard Locksley, MD

Sandler Distinguished Professor, Medicine
Howard Hughes Medical Institute Investigator

Address

513 Parnassus Avenue, MSB, #1032B
San Francisco, CA 94143
United States

Email: [email protected]
Phone: 415-476-1559
Fax: 415-502-5081

ORCID: 0000-0002-5468-6867

Education

Institution Degree Dept or School End Date
University of Washington Infect Diseases Fellow 1980-83
University of California, San Francisco Resident/Chief Resident 1976-80
University of Rochester M.D. Medicine 06/1976
Harvard College B.A. Biochemistry 06/1970

Awards & Honors

Award Conferred By Date
Fellow, American Academy of Microbiology 2017
Inaugural William Paul Award for Cytokine Research, International Cytokine & Interferon Society 2017
National Academy of Sciences 2017
Thomson Reuters ‘Top 1% highly cited researchers in immunology’ 2014
R37 MERIT Award, NIAID/NIH 2006
American Academy of Arts & Sciences 2005
Distinguished Service Award, American Association of Immunologists 2003
Inspirational Teacher Award, UCSF class of 2006 2003
Sandler Distinguished Professorship 2003
Ellison Medical Foundation Senior Scholar in Global Infectious Diseases 2001/2005
Association of American Physicians 1994
Bailey K Ashford Medal, American Society Tropical Medicine and Hygiene 1994
Burroughs Wellcome Fund Scholar in Molecular Parasitology 1992/1997
Fellow, Infectious Diseases Society of American 1992
American Society for Clinical Investigation 1991

Grants and Funding

  • Exploring the biology of persistent type 2 airway niches in asthma | NIH | 2012-08-15 - 2024-07-31 | Role: Co-Investigator
  • Parasite immunity orchestrated by type 2 immune cells | NIH | 1988-07-01 - 2023-04-30 | Role: Principal Investigator
  • Understanding Asthma Endotypes | NIH | 2008-04-01 - 2023-03-31 | Role: Co-Investigator
  • Biology of Infectious Diseases Training Program | NIH | 2000-08-01 - 2022-08-31 | Role: Co-Principal Investigator
  • Epithelial chitinase and lung homeostasis | NIH | 2015-07-01 - 2019-04-30 | Role: Principal Investigator
  • Initiation of allergic immunity by parasites | NIH | 1991-01-01 - 2018-05-31 | Role: Principal Investigator
  • Parasite Immunity Orchestrated by Th2 Cells | NIH | 1988-07-01 - 2017-03-31 | Role: Principal Investigator
  • Innate immune regulation of inflammation and adaptive immunity | NIH | 2008-07-15 - 2014-06-30 | Role: Co-Investigator
  • Interactions of Lymphocytes, Cytokines and Airway Cells | NIH | 1996-09-30 - 2006-08-31 | Role: Co-Principal Investigator
  • PSYCHOLOGICAL WELL-BEING OF LABORATORY-PAIRED PRIMATES | NIH | 1989-09-15 - 1993-06-30 | Role: Co-Investigator
  • HUMAN PHAGOCYTE FUNCTION IN HEALTH AND DISEASE | NIH | 1983-09-30 - 1986-08-31 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 282
  1. An ILC2-chitinase circuit restores lung homeostasis after epithelial injury.
    Jung H, Kim DH, Díaz RE, White JM, Rucknagel S, Mosby L, Wang Y, Reddy S, Winkler ES, Hassan AO, Ying B, Diamond MS, Locksley RM, Fraser JS, Van Dyken SJ| | PubMed
  2. Telocytes link epithelial nutrient sensing with amplification of the ILC2-tuft cell circuit.
    Liao C, Ji M, Wang ZE, Drucker DJ, Liang HE, Locksley RM| | PubMed
  3. Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue.
    Schuijs MJ, Brenis Gomez CM, Bick F, Van Moorleghem J, Vanheerswynghels M, van Loo G, Beyaert R, Voehringer D, Locksley RM, Hammad H, Lambrecht BN| | PubMed
  4. Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
    Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken S, Locksley RM, Fraser JS| | PubMed
  5. Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
    Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS| | PubMed
  6. Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti-helminth defences.
    Rekima A, van den Elsen L, Isnard C, Smyth DJ, Lynn MA, Yee T, Stevens NE, Machado S, Divakara N, Bhasin M, Tjiam MC, Rowel C, Servant F, Burcelin R, Locksley R, Maizels R, Lynn DJ, Egwang T, Verhasselt V| | PubMed
  7. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
    Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD| | PubMed
  8. A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development.
    O'Keefe RN, Carli ALE, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, Eissmann MF, Poh AR, Pal B, Seillet C, Locksley RM, Ernst M, Buchert M| | PubMed
  9. Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites.
    Shaikh N, Waterhölter A, Gnirck AC, Becker M, Adamiak V, Henneken L, Wunderlich M, Hartmann W, Linnemann L, Huber TB, Krebs CF, Panzer U, Locksley RM, Wilhelm C, Breloer M, Turner JE| | PubMed
  10. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
    Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD| | PubMed
282
View all 282 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 282
  1. An ILC2-chitinase circuit restores lung homeostasis after epithelial injury.
    Jung H, Kim DH, Díaz RE, White JM, Rucknagel S, Mosby L, Wang Y, Reddy S, Winkler ES, Hassan AO, Ying B, Diamond MS, Locksley RM, Fraser JS, Van Dyken SJ| | PubMed
  2. Telocytes link epithelial nutrient sensing with amplification of the ILC2-tuft cell circuit.
    Liao C, Ji M, Wang ZE, Drucker DJ, Liang HE, Locksley RM| | PubMed
  3. Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue.
    Schuijs MJ, Brenis Gomez CM, Bick F, Van Moorleghem J, Vanheerswynghels M, van Loo G, Beyaert R, Voehringer D, Locksley RM, Hammad H, Lambrecht BN| | PubMed
  4. Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
    Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken S, Locksley RM, Fraser JS| | PubMed
  5. Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
    Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS| | PubMed
  6. Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti-helminth defences.
    Rekima A, van den Elsen L, Isnard C, Smyth DJ, Lynn MA, Yee T, Stevens NE, Machado S, Divakara N, Bhasin M, Tjiam MC, Rowel C, Servant F, Burcelin R, Locksley R, Maizels R, Lynn DJ, Egwang T, Verhasselt V| | PubMed
  7. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
    Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD| | PubMed
  8. A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development.
    O'Keefe RN, Carli ALE, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, Eissmann MF, Poh AR, Pal B, Seillet C, Locksley RM, Ernst M, Buchert M| | PubMed
  9. Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites.
    Shaikh N, Waterhölter A, Gnirck AC, Becker M, Adamiak V, Henneken L, Wunderlich M, Hartmann W, Linnemann L, Huber TB, Krebs CF, Panzer U, Locksley RM, Wilhelm C, Breloer M, Turner JE| | PubMed
  10. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
    Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD| | PubMed
  11. Immune treatment tackles chronic obstructive pulmonary disease.
    Fahy JV, Locksley RM| | PubMed
  12. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.
    Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB| | PubMed
  13. The ins and outs of innate and adaptive type 2 immunity.
    Molofsky AB, Locksley RM| | PubMed
  14. Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage.
    Kotas ME, O'Leary CE, Locksley RM| | PubMed
  15. Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
    Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM| | PubMed
  16. IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.
    Kotas ME, Moore CM, Gurrola JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED| | PubMed
  17. Bile acid-sensitive tuft cells regulate biliary neutrophil influx.
    O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM| | PubMed
  18. ILC2s - development, divergence, dispersal.
    Ricardo-Gonzalez RR, Molofsky AB, Locksley RM| | PubMed
  19. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
    Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB| | PubMed
  20. Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
    Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS| | PubMed
  21. Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth.
    Gschwend J, Sherman SPM, Ridder F, Feng X, Liang HE, Locksley RM, Becher B, Schneider C| | PubMed
  22. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
    Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM| | PubMed
  23. Corrections.
    O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C| | PubMed
  24. A role for IL-33-activated ILC2s in eosinophilic vasculitis.
    Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B| | PubMed
  25. A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression.
    Kastenschmidt JM, Coulis G, Farahat PK, Pham P, Rios R, Cristal TT, Mannaa AH, Ayer RE, Yahia R, Deshpande AA, Hughes BS, Savage AK, Giesige CR, Harper SQ, Locksley RM, Mozaffar T, Villalta SA| | PubMed
  26. Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo Manipulations.
    O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C| | PubMed
  27. Skin-resident innate lymphoid cells converge on a pathogenic effector state.
    Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA| | PubMed
  28. In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.
    Zeis P, Lian M, Fan X, Herman JS, Hernandez DC, Gentek R, Elias S, Symowski C, Knöpper K, Peltokangas N, Friedrich C, Doucet-Ladeveze R, Kabat AM, Locksley RM, Voehringer D, Bajenoff M, Rudensky AY, Romagnani C, Grün D, Gasteiger G| | PubMed
  29. Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.
    Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM| | PubMed
  30. Tissue immunity broadcasts near and far.
    Molofsky AB, Locksley RM| | PubMed
  31. Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates.
    Barad BA, Liu L, Diaz RE, Basilio R, Van Dyken SJ, Locksley RM, Fraser JS| | PubMed
  32. Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis.
    Howe M, Bauer J, Schulze A, Kropp S, Locksley RM, Alferink J, Weighardt H, Scheu S| | PubMed
  33. Regulation of immune responses by tuft cells.
    Schneider C, O'Leary CE, Locksley RM| | PubMed
  34. Making Asthma Crystal Clear.
    Fahy JV, Locksley RM| | PubMed
  35. ILC2s chew the fat.
    Ricardo-Gonzalez RR, Locksley RM| | PubMed
  36. Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.
    Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM| | PubMed
  37. Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry.
    O'Leary CE, Schneider C, Locksley RM| | PubMed
  38. Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.
    Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD| | PubMed
  39. Tissue signals imprint ILC2 identity with anticipatory function.
    Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM| | PubMed
  40. Innate Lymphoid Cells: 10 Years On.
    Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H| | PubMed
  41. Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
    Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS| | PubMed
  42. Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
    Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J| | PubMed
  43. Chitins and chitinase activity in airway diseases.
    Van Dyken SJ, Locksley RM| | PubMed
  44. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.
    Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD| | PubMed
  45. Why Innate Lymphoid Cells?
    Kotas ME, Locksley RM| | PubMed
  46. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.
    Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM| | PubMed
  47. Pulmonary neuroendocrine cells amplify allergic asthma responses.
    Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X| | PubMed
  48. Perinatal Licensing of Thermogenesis by IL-33 and ST2.
    Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A| | PubMed
  49. MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
    Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM| | PubMed
  50. Turning the light on.
    Locksley R| | PubMed
  51. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine.
    Savage AK, Liang HE, Locksley RM| | PubMed
  52. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.
    Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR| | PubMed
  53. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
    Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM| | PubMed
  54. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.
    von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM| | PubMed
  55. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.
    Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL| | PubMed
  56. A tissue checkpoint regulates type 2 immunity.
    Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM| | PubMed
  57. Perinatal Licensing of Thermogenesis by IL-33 and ST2.
    Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A| | PubMed
  58. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.
    Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD| | PubMed
  59. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.
    Gordon ED, Locksley RM, Fahy JV| | PubMed
  60. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.
    von Moltke J, Ji M, Liang HE, Locksley RM| | PubMed
  61. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
    Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM| | PubMed
  62. Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.
    Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM| | PubMed
  63. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation.
    Molofsky AB, Savage AK, Locksley RM| | PubMed
  64. New blood: Creative funding of disease-specific research.
    Seaman WE, Locksley RM, Welsh MJ| | PubMed
  65. Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.
    Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D| | PubMed
  66. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.
    Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM| | PubMed
  67. A novel model for IFN-γ-mediated autoinflammatory syndromes.
    Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM| | PubMed
  68. Activated type 2 innate lymphoid cells regulate beige fat biogenesis.
    Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A| | PubMed
  69. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.
    Bando JK, Liang HE, Locksley RM| | PubMed
  70. Allergic inflammation--innately homeostatic.
    Cheng LE, Locksley RM| | PubMed
  71. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.
    Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA| | PubMed
  72. I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis.
    von Moltke J, Locksley RM| | PubMed
  73. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.
    Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A| | PubMed
  74. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.
    Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD| | PubMed
  75. Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.
    O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP| | PubMed
  76. Asthma and the flu: a tricky two-step.
    Locksley RM, Fahy JV| | PubMed
  77. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
    Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM| | PubMed
  78. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.
    Hams E, Locksley RM, McKenzie AN, Fallon PG| | PubMed
  79. Type 2 innate lymphoid cells control eosinophil homeostasis.
    Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM| | PubMed
  80. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung.
    Bando JK, Nussbaum JC, Liang HE, Locksley RM| | PubMed
  81. Traumatic brain injury induces macrophage subsets in the brain.
    Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE| | PubMed
  82. Eosinophils secrete IL-4 to facilitate liver regeneration.
    Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A| | PubMed
  83. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
    Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A| | PubMed
  84. Raggin' on T-bet.
    Locksley RM| | PubMed
  85. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
    Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM| | PubMed
  86. Innate lymphoid cells--a proposal for uniform nomenclature.
    Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E| | PubMed
  87. Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse.
    Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR| | PubMed
  88. Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease.
    Van Dyken SJ, Locksley RM| | PubMed
  89. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.
    Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM| | PubMed
  90. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.
    Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF| | PubMed
  91. Marking and quantifying IL-17A-producing cells in vivo.
    Price AE, Reinhardt RL, Liang HE, Locksley RM| | PubMed
  92. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
    Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF| | PubMed
  93. Infectious (Non)tolerance--frustrated commensalism gone awry?
    Nussbaum JC, Locksley RM| | PubMed
  94. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.
    Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM| | PubMed
  95. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.
    Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A| | PubMed
  96. Deletion of Syk in neutrophils prevents immune complex arthritis.
    Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA| | PubMed
  97. A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness.
    Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV| | PubMed
  98. The airway epithelium as a regulator of Th2 responses in asthma.
    Fahy JV, Locksley RM| | PubMed
  99. Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.
    Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM| | PubMed
  100. Genetic analysis of basophil function in vivo.
    Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM| | PubMed
  101. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
    Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM| | PubMed
  102. Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.
    Svensson M, Bell L, Little MC, DeSchoolmeester M, Locksley RM, Else KJ| | PubMed
  103. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.
    Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A| | PubMed
  104. Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes.
    Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW| | PubMed
  105. Lymphocyte development requires S-nitrosoglutathione reductase.
    Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, Liu L| | PubMed
  106. Murine B cells regulate serum IgE levels in a CD23-dependent manner.
    Cheng LE, Wang ZE, Locksley RM| | PubMed
  107. Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
    Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM| | PubMed
  108. Asthma and allergic inflammation.
    Locksley RM| | PubMed
  109. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands.
    Barbalat R, Lau L, Locksley RM, Barton GM| | PubMed
  110. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
    Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B| | PubMed
  111. Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates.
    Voehringer D, Wu D, Liang HE, Locksley RM| | PubMed
  112. Nine lives: plasticity among T helper cell subsets.
    Locksley RM| | PubMed
  113. In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli.
    Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A| | PubMed
  114. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway.
    Kroeger KM, Sullivan BM, Locksley RM| | PubMed
  115. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
    Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG| | PubMed
  116. Cytokine-secreting follicular T cells shape the antibody repertoire.
    Reinhardt RL, Liang HE, Locksley RM| | PubMed
  117. The inflammasome and alum-mediated adjuvanticity.
    Kang SJ, Locksley RM| | PubMed
  118. Basophils: a nonredundant contributor to host immunity.
    Sullivan BM, Locksley RM| | PubMed
  119. Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo.
    Scheu S, Dresing P, Locksley RM| | PubMed
  120. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
    Kang SJ, Liang HE, Reizis B, Locksley RM| | PubMed
  121. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
    Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL| | PubMed
  122. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration.
    Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM| | PubMed
  123. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
    Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B| | PubMed
  124. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.
    Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH| | PubMed
  125. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice.
    Voehringer D, Liang HE, Locksley RM| | PubMed
  126. The Roaring Twenties.
    Locksley RM| | PubMed
  127. Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity.
    Van Dyken SJ, Locksley RM| | PubMed
  128. Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
    Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M| | PubMed
  129. A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes.
    Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C| | PubMed
  130. Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major.
    Launois P, Pingel S, Himmelrich H, Locksley R, Louis J| | PubMed
  131. Chitin induces accumulation in tissue of innate immune cells associated with allergy.
    Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM| | PubMed
  132. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.
    Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM| | PubMed
  133. Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.
    Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley RM| | PubMed
  134. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages.
    Voehringer D, van Rooijen N, Locksley RM| | PubMed
  135. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
    Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH| | PubMed
  136. A failure to launch: fuelling cytokine secretion in iNKT cells.
    Locksley RM| | PubMed
  137. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
    Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA| | PubMed
  138. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
    Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM| | PubMed
  139. LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major.
    Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J| | PubMed
  140. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.
    Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM| | PubMed
  141. Activation of the integrated stress response during T helper cell differentiation.
    Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM| | PubMed
  142. Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence.
    Hayashida T, Oda M, Ohsawa K, Yamaguchi A, Hosozawa T, Locksley RM, Giacca M, Masai H, Miyatake S| | PubMed
  143. T helper cell effector fates--who, how and where?
    Reinhardt RL, Kang SJ, Liang HE, Locksley RM| | PubMed
  144. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
    Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B| | PubMed
  145. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
    Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA| | PubMed
  146. Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds.
    Im W, Kim H, Yun D, Seo SY, Park SH, Locksley RM, Hong S| | PubMed
  147. A two-step process for cytokine production revealed by IL-4 dual-reporter mice.
    Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M| | PubMed
  148. Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.
    Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP| | PubMed
  149. Interleukin-4 can be a key positive regulator of inflammatory arthritis.
    Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C| | PubMed
  150. The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice.
    Kelly BL, Locksley RM| | PubMed
  151. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.
    Voehringer D, Rosen DB, Lanier LL, Locksley RM| | PubMed
  152. Innate immune responses in peptidoglycan recognition protein L-deficient mice.
    Xu M, Wang Z, Locksley RM| | PubMed
  153. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production.
    Voehringer D, Shinkai K, Locksley RM| | PubMed
  154. Th2 cells: orchestrating barrier immunity.
    Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM| | PubMed
  155. Basal chromatin modification at the IL-4 gene in helper T cells.
    Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley RM| | PubMed
  156. Leishmania major LACK antigen is required for efficient vertebrate parasitization.
    Kelly BL, Stetson DB, Locksley RM| | PubMed
  157. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.
    Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM| | PubMed
  158. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.
    Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M| | PubMed
  159. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity.
    Hadeiba H, Locksley RM| | PubMed
  160. Stat signals release activated naive Th cells from an anergic checkpoint.
    Mohrs M, Lacy DA, Locksley RM| | PubMed
  161. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
    Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA| | PubMed
  162. Helper T cells regulate type-2 innate immunity in vivo.
    Shinkai K, Mohrs M, Locksley RM| | PubMed
  163. Blood lines.
    Locksley RM| | PubMed
  164. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.
    Stetson DB, Mohrs M, Mallet-Designe V, Teyton L, Locksley RM| | PubMed
  165. T helper cell differentiation: on again, off again.
    Grogan JL, Locksley RM| | PubMed
  166. Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in non
    Launois P, Gumy A, Himmelrich H, Locksley RM, Röcken M, Louis JA| | PubMed
  167. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection.
    Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D| | PubMed
  168. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.
    Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA| | PubMed
  169. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.
    Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH| | PubMed
  170. Deletion of a coordinate regulator of type 2 cytokine expression in mice.
    Mohrs M, Blankespoor CM, Wang ZE, Loots GG, Afzal V, Hadeiba H, Shinkai K, Rubin EM, Locksley RM| | PubMed
  171. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter.
    Mohrs M, Shinkai K, Mohrs K, Locksley RM| | PubMed
  172. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis.
    Bottrel RL, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Netto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ| | PubMed
  173. Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice.
    Maillard I, Launois P, Himmelrich H, Acha-Orbea H, Diggelmann H, Locksley RM, Louis JA| | PubMed
  174. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.
    Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM| | PubMed
  175. The TNF and TNF receptor superfamilies: integrating mammalian biology.
    Locksley RM, Killeen N, Lenardo MJ| | PubMed
  176. Flying doctors.
    Locksley RM| | PubMed
  177. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns.
    Kelly BL, Locksley RM| | PubMed
  178. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells.
    Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA| | PubMed
  179. Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system.
    Hadeiba H, Corry DB, Locksley RM| | PubMed
  180. Faithful expression of the human 5q31 cytokine cluster in transgenic mice.
    Lacy DA, Wang ZE, Symula DJ, McArthur CJ, Rubin EM, Frazer KA, Locksley RM| | PubMed
  181. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease.
    Himmelrich H, Launois P, Maillard I, Biedermann T, Tacchini-Cottier F, Locksley RM, Röcken M, Louis JA| | PubMed
  182. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.
    Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA| | PubMed
  183. CD1, tuberculosis, and the evolution of major histocompatibility complex molecules.
    Shinkai K, Locksley RM| | PubMed
  184. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).
    Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N| | PubMed
  185. Functional screening of an asthma QTL in YAC transgenic mice.
    Symula DJ, Frazer KA, Ueda Y, Denefle P, Stevens ME, Wang ZE, Locksley R, Rubin EM| | PubMed
  186. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.
    Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM| | PubMed
  187. Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases.
    Fowell DJ, Locksley RM| | PubMed
  188. Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
    Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM| | PubMed
  189. Susceptibility to infectious diseases: Leishmania as a paradigm.
    Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ| | PubMed
  190. Construction of polycompetitors for competitive PCR.
    Corry DB, Locksley RM| | PubMed
  191. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism.
    Bix M, Wang ZE, Thiel B, Schork NJ, Locksley RM| | PubMed
  192. Requirement for IL-13 independently of IL-4 in experimental asthma.
    Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB| | PubMed
  193. Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.
    Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM| | PubMed
  194. Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.
    Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM| | PubMed
  195. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells.
    Bix M, Locksley RM| | PubMed
  196. Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors.
    Joiner KA, Powderly WG, Blaser MJ, Klempner MS, Locksley RM, Mandell GL, Preheim LC, Remington JS, Slama TG, Steigbigel NH, Bartlett JG| | PubMed
  197. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.
    Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM| | PubMed
  198. Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets.
    Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M| | PubMed
  199. Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
    Pingel S, Wang ZE, Locksley RM| | PubMed
  200. Macromolecular contrast media-enhanced MRI estimates of microvascular permeability correlate with histopathologic tumor grade.
    Brasch RC, Daldrup H, Shames D, Wendland M, Okuhata Y, Rosenau W| | PubMed
  201. Control of Leishmania major by a monoclonal alpha beta T cell repertoire.
    Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM| | PubMed
  202. Development of CD4+ effector T cells and susceptibility to infectious diseases.
    Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M| | PubMed
  203. Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells.
    McSorley SJ, Soldera S, Malherbe L, Carnaud C, Locksley RM, Flavell RA, Glaichenhaus N| | PubMed
  204. Altered immune responses in interleukin 10 transgenic mice.
    Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M| | PubMed
  205. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice.
    Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA| | PubMed
  206. Impaired Th2 subset development in the absence of CD4.
    Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM| | PubMed
  207. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.
    Stevenson FT, Turck J, Locksley RM, Lovett DH| | PubMed
  208. T helper subset differentiation in the absence of invariant chain.
    Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL| | PubMed
  209. Exploitation of immune and other defence mechanisms by parasites: an overview.
    Locksley RM| | PubMed
  210. Leishmania major: targeting IL-4 in successful immunomodulation of murine infection.
    Wakil AE, Wang ZE, Locksley RM| | PubMed
  211. Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.
    Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL| | PubMed
  212. Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis.
    Corry DB, Ampel NM, Christian L, Locksley RM, Galgiani JN| | PubMed
  213. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.
    Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ| | PubMed
  214. The instructive role of innate immunity in the acquired immune response.
    Fearon DT, Locksley RM| | PubMed
  215. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
    Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM| | PubMed
  216. Interleukin-12 in murine leishmaniasis--match, flame or fuel?
    Fowell DJ, Wakil AE, Locksley RM| | PubMed
  217. Natural T cells. Cells that co-express NKRP-1 and TCR.
    Bix M, Locksley RM| | PubMed
  218. Expression cloning of a protective Leishmania antigen.
    Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N| | PubMed
  219. The development of effector T cell subsets in murine Leishmania major infection.
    Locksley RM, Wakil AE, Corry DB, Pingel S, Bix M, Fowell DJ| | PubMed
  220. The regulation of immunity to Leishmania major.
    Reiner SL, Locksley RM| | PubMed
  221. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.
    Wang ZE, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM| | PubMed
  222. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.
    Corry DB, Reiner SL, Linsley PS, Locksley RM| | PubMed
  223. Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46; 173(1994) 133).
    Reiner SL, Zheng S, Corry DB, Locksley RM| | PubMed
  224. Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46).
    Reiner SL, Zheng S, Corry DB, Locksley RM| | PubMed
  225. Th2 cells: help for helminths.
    Locksley RM| | PubMed
  226. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.
    Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM| | PubMed
  227. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.
    Reiner SL, Zheng S, Wang ZE, Stowring L, Locksley RM| | PubMed
  228. Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis.
    Reiner SL, Locksley RM| | PubMed
  229. Potential role for interleukin-10 in the immunosuppression associated with kala azar.
    Holaday BJ, Pompeu MM, Jeronimo S, Texeira MJ, Sousa Ade A, Vasconcelos AW, Pearson RD, Abrams JS, Locksley RM| | PubMed
  230. Constructing polycompetitor cDNAs for quantitative PCR.
    Reiner SL, Zheng S, Corry DB, Locksley RM| | PubMed
  231. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
    Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N| | PubMed
  232. Reconstitution of Mycobacterium leprae immunity in severe combined immunodeficient mice using a T-cell line.
    Azouaou N, Gelber RH, Abel K, Sasaki DT, Murray LP, Locksley RM, Mohagheghpour N| | PubMed
  233. Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis.
    Wang ZE, Reiner SL, Hatam F, Heinzel FP, Bouvier J, Turck CW, Locksley RM| | PubMed
  234. The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.
    Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH| | PubMed
  235. Interleukin 12 in host defense against microbial pathogens.
    Locksley RM| | PubMed
  236. The worm and the protozoa: stereotyped responses or distinct antigens?
    Reiner SL, Locksley RM| | PubMed
  237. Transfected Leishmania expressing biologically active IFN-gamma.
    Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM| | PubMed
  238. IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.
    Heinzel FP, Rerko RM, Hatam F, Locksley RM| | PubMed
  239. TH1 and TH2 cell antigen receptors in experimental leishmaniasis.
    Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM| | PubMed
  240. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.
    Stevenson FT, Bursten SL, Locksley RM, Lovett DH| | PubMed
  241. Immunology of leishmaniasis.
    Locksley RM, Louis JA| | PubMed
  242. Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms.
    Stevenson FT, Torrano F, Locksley RM, Lovett DH| | PubMed
  243. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice.
    Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH| | PubMed
  244. Lessons from Leishmania: a model for investigations of CD4+ subset differentiation.
    Reiner SL, Locksley RM| | PubMed
  245. Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice.
    Sadick MD, Street N, Mosmann TR, Locksley RM| | PubMed
  246. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.
    Holaday BJ, Sadick MD, Wang ZE, Reiner SL, Heinzel FP, Parslow TG, Locksley RM| | PubMed
  247. Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.
    Heinzel FP, Sadick MD, Mutha SS, Locksley RM| | PubMed
  248. Activation of human monocyte--derived macrophages with lipopolysaccharide decreases human immunodeficiency virus replication in vitro at the level of gene expression.
    Bernstein MS, Tong-Starksen SE, Locksley RM| | PubMed
  249. A single peptide from the major outer membrane protein of Chlamydia trachomatis elicits T cell help for the production of antibodies to protective determinants.
    Allen JE, Locksley RM, Stephens RS| | PubMed
  250. Cytokines in fluids from polycystic kidneys.
    Gardner KD, Burnside JS, Elzinga LW, Locksley RM| | PubMed
  251. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function.
    Locksley RM, Scott P| | PubMed
  252. Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection.
    Locksley RM, Heinzel FP, Holaday BJ, Mutha SS, Reiner SL, Sadick MD| | PubMed
  253. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.
    Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM| | PubMed
  254. The exposure of health care workers to ribavirin aerosol.
    Guglielmo BJ, Jacobs RA, Locksley RM| | PubMed
  255. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.
    Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM| | PubMed
  256. Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo.
    Locksley RM, Crowe S, Sadick MD, Heinzel FP, Gardner KD, McGrath MS, Mills J| | PubMed
  257. Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors.
    Bursten SL, Locksley RM, Ryan JL, Lovett DH| | PubMed
  258. Fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient.
    Hamadeh R, Ardehali A, Locksley RM, York MK| | PubMed
  259. Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice.
    Heinzel FP, Sadick MD, Locksley RM| | PubMed
  260. Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote.
    Locksley RM, Heinzel FP, Fankhauser JE, Nelson CS, Sadick MD| | PubMed
  261. Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells.
    Locksley RM, Heinzel FP, Shepard HM, Agosti J, Eessalu TE, Aggarwal BB, Harlan JM| | PubMed
  262. Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets.
    Locksley RM, Heinzel FP, Sadick MD, Holaday BJ, Gardner KD| | PubMed
  263. Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.
    Sadick MD, Heinzel FP, Shigekane VM, Fisher WL, Locksley RM| | PubMed
  264. Loss of granule myeloperoxidase during in vitro culture of human monocytes correlates with decay in antiprotozoa activity.
    Locksley RM, Nelson CS, Fankhauser JE, Klebanoff SJ| | PubMed
  265. Isolation and characterization of the receptor on human neutrophils that mediates cellular adherence.
    Hickstein DD, Ozols J, Williams SA, Baenziger JU, Locksley RM, Roth GJ| | PubMed
  266. Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells.
    Hickstein DD, Smith A, Fisher W, Beatty PG, Schwartz BR, Harlan JM, Root RK, Locksley RM| | PubMed
  267. Monoclonal antibodies binding to the human neutrophil C3bi receptor have disparate functional effects.
    Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK| | PubMed
  268. Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro.
    Sadick MD, Locksley RM, Tubbs C, Raff HV| | PubMed
  269. Infection with varicella-zoster virus after marrow transplantation.
    Locksley RM, Flournoy N, Sullivan KM, Meyers JD| | PubMed
  270. Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii.
    Locksley RM, Fankhauser J, Henderson WR| | PubMed
  271. Development of cellular immunity in cutaneous leishmaniasis due to Leishmania tropica.
    Sadick MD, Locksley RM, Raff HV| | PubMed
  272. Interaction of primate alveolar macrophages and Legionella pneumophila.
    Jacobs RF, Locksley RM, Wilson CB, Haas JE, Klebanoff SJ| | PubMed
  273. Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood-brain barrier.
    Ryser RJ, Locksley RM, Eng SC, Dobbins WO, Schoenknecht FD, Rubin CE| | PubMed
  274. Increased respiratory burst in myeloperoxidase-deficient monocytes.
    Locksley RM, Wilson CB, Klebanoff SJ| | PubMed
  275. Oxidative response of phagocytes to parasite invasion.
    Klebanoff SJ, Locksley RM, Jong EC, Rosen H| | PubMed
  276. Oxygen-dependent microbicidal systems of phagocytes and host defense against intracellular protozoa.
    Locksley RM, Klebanoff SJ| | PubMed
  277. Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems.
    Locksley RM, Jacobs RF, Wilson CB, Weaver WM, Klebanoff SJ| | PubMed
  278. Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection.
    Locksley RM, Cohen ML, Quinn TC, Tompkins LS, Coyle MB, Kirihara JM, Counts GW| | PubMed
  279. Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes.
    Locksley RM, Wilson CB, Klebanoff SJ| | PubMed
  280. Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients.
    Ashraf N, Locksley R, Arieff AI| | PubMed
  281. Prognostic grading and significance of ventricular premature beats after recovery from myocardial infarction.
    Moss AJ, DeCamilla J, Mietlowski W, Greene WA, Goldstein S, Locksley R| | PubMed
  282. Two improvements in the preparation of cardiac microsomes.
    Stam AC, Sole M, Locksley R, Weglicki WB, Sonnenblick EH| | PubMed