University of California San Francisco

Richard Locksley, MD

Richard Locksley, MD
Richard Locksley, MD

Sandler Distinguished Professor, Medicine
Howard Hughes Medical Institute Investigator

Address

513 Parnassus Avenue MSB, #1032B
San Francisco, CA 94143
United States

Email: [email protected]

ORCID: 0000-0002-5468-6867

Education

Institution Degree Dept or School End Date
University of Washington Infect Diseases Fellow 1980-83
University of California, San Francisco Resident/Chief Resident 1976-80
University of Rochester M.D. Medicine 06/1976
Harvard College B.A. Biochemistry 06/1970

Awards & Honors

Award Conferred By Date
Fellow, American Academy of Microbiology 2017
Inaugural William Paul Award for Cytokine Research, International Cytokine & Interferon Society 2017
National Academy of Sciences 2017
Thomson Reuters ‘Top 1% highly cited researchers in immunology’ 2014
R37 MERIT Award, NIAID/NIH 2006
American Academy of Arts & Sciences 2005
Distinguished Service Award, American Association of Immunologists 2003
Inspirational Teacher Award, UCSF class of 2006 2003
Sandler Distinguished Professorship 2003
Ellison Medical Foundation Senior Scholar in Global Infectious Diseases 2001/2005
Association of American Physicians 1994
Bailey K Ashford Medal, American Society Tropical Medicine and Hygiene 1994
Burroughs Wellcome Fund Scholar in Molecular Parasitology 1992/1997
Fellow, Infectious Diseases Society of American 1992
American Society for Clinical Investigation 1991

Grants and Funding

  • Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma | NIH | 2008-04-01 - 2028-03-31 | Role: Co-Investigator
  • Biology of Infectious Diseases Training Program | NIH | 2000-08-01 - 2027-08-31 | Role: Co-Principal Investigator
  • Exploring the biology of persistent type 2 airway niches in asthma | NIH | 2012-08-15 - 2024-07-31 | Role: Co-Investigator
  • Parasite immunity orchestrated by type 2 immune cells | NIH | 1988-07-01 - 2023-04-30 | Role: Principal Investigator
  • Epithelial chitinase and lung homeostasis | NIH | 2015-07-01 - 2019-04-30 | Role: Principal Investigator
  • Initiation of allergic immunity by parasites | NIH | 1991-01-01 - 2018-05-31 | Role: Principal Investigator
  • Parasite Immunity Orchestrated by Th2 Cells | NIH | 1988-07-01 - 2017-03-31 | Role: Principal Investigator
  • Innate immune regulation of inflammation and adaptive immunity | NIH | 2008-07-15 - 2014-06-30 | Role: Co-Investigator
  • Interactions of Lymphocytes, Cytokines and Airway Cells | NIH | 1996-09-30 - 2006-08-31 | Role: Co-Principal Investigator
  • PSYCHOLOGICAL WELL-BEING OF LABORATORY-PAIRED PRIMATES | NIH | 1989-09-15 - 1993-06-30 | Role: Co-Investigator
  • HUMAN PHAGOCYTE FUNCTION IN HEALTH AND DISEASE | NIH | 1983-09-30 - 1986-08-31 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 10
  1. Circulating inflammatory ILC2s as a biomarker of gastric cancer progression.
    O'Keefe RN, Raghunathan K, Eissmann MF, Baloyan D, Poh AR, O'Brien M, Clapdorp E, Afshar-Sterle S, Locksley RM, Ernst M, Buchert M| | PubMed
  2. Parasites trigger epithelial cell crosstalk to drive gut-brain signalling.
    Touhara KK, Xu J, Castro J, Liang HE, Li G, Brizuela M, Harrington AM, Garcia-Caraballo S, O'Donnell T, Neumann D, Rossen ND, Deng F, Schober G, Li Y, Locksley RM, Brierley SM, Julius D| | PubMed
  3. Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches.
    Sbierski-Kind J, Cautivo KM, Nilsson J, Wagner JC, Dahlgren MW, Crystal NE, McClave M, Mroz NM, Ganslmeier M, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Lee JH, Gu T, Seo H, Kim HJ, Mattis AN, Peng T, Locksley RM, Molofsky AB| | PubMed
  4. TSLP links intestinal nutrient sensing with amplification of the ILC2-tuft cell circuit.
    Liao C, Mennillo E, Kattah MG, Ji M, Wang ZE, Drucker DJ, Liang HE, Locksley RM| | PubMed
  5. IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity.
    Cortez VS, Viragova S, Koga S, Liu M, O'Leary CE, Ricardo-Gonzalez RR, Schroeder AW, Kochhar N, Vaka D, Boffelli D, Klein OD, Diamond MS, Liang HE, Locksley RM| | PubMed
  6. RORγt eTACs mediate oral tolerance and Treg induction.
    Sun IH, Qualls AE, Yin HS, Wang J, Arvedson MP, Germino J, Horner NK, Zhong S, Du J, Valdearcos M, Ntranos V, Locksley RM, Ricardo-Gonzalez RR, Gardner JM| | PubMed
  7. Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB.
    Lee Y, Ishikawa T, Lee H, Lee B, Ryu C, Davila Mejia I, Kim M, Lu G, Hong Y, Feng M, Shin H, Meloche S, Locksley RM, Koltsova E, Grivennikov SI, Heiman M, Choi GB, Huh JR| | PubMed
  8. IL-25-induced memory ILC2s mediate long-term small intestinal adaptation.
    Cortez VS, Viragova S, Koga S, Liu M, O'Leary CE, Ricardo-Gonzalez RR, Schroeder AW, Kochhar N, Klein OD, Diamond MS, Liang HE, Locksley RM| | PubMed
  9. An ILC2-chitinase circuit restores lung homeostasis after epithelial injury.
    Jung H, Kim DH, Díaz RE, White JM, Rucknagel S, Mosby L, Wang Y, Reddy S, Winkler ES, Hassan AO, Ying B, Diamond MS, Locksley RM, Fraser JS, Van Dyken SJ| | PubMed
  10. Telocytes link epithelial nutrient sensing with amplification of the ILC2-tuft cell circuit.
    Liao C, Ji M, Wang ZE, Drucker DJ, Liang HE, Locksley RM| | PubMed