An ILC2-chitinase circuit restores lung homeostasis after epithelial injury.
Jung H, Kim DH, Díaz RE, White JM, Rucknagel S, Mosby L, Wang Y, Reddy S, Winkler ES, Hassan AO, Ying B, Diamond MS, Locksley RM, Fraser JS, Van Dyken SJ 2024-10-18
PubMed
Telocytes link epithelial nutrient sensing with amplification of the ILC2-tuft cell circuit.
Liao C, Ji M, Wang ZE, Drucker DJ, Liang HE, Locksley RM 2024-10-17
PubMed
Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue.
Schuijs MJ, Brenis Gomez CM, Bick F, Van Moorleghem J, Vanheerswynghels M, van Loo G, Beyaert R, Voehringer D, Locksley RM, Hammad H, Lambrecht BN 2024-09-19
PubMed
Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken S, Locksley RM, Fraser JS 2024-06-17
PubMed
Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS 2024-03-25
PubMed
Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti-helminth defences.
Rekima A, van den Elsen L, Isnard C, Smyth DJ, Lynn MA, Yee T, Stevens NE, Machado S, Divakara N, Bhasin M, Tjiam MC, Rowel C, Servant F, Burcelin R, Locksley R, Maizels R, Lynn DJ, Egwang T, Verhasselt V 2024-02-13
PubMed
Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD 2024-02-06
PubMed
A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development.
O'Keefe RN, Carli ALE, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, Eissmann MF, Poh AR, Pal B, Seillet C, Locksley RM, Ernst M, Buchert M 2023-10-28
PubMed
Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites.
Shaikh N, Waterhölter A, Gnirck AC, Becker M, Adamiak V, Henneken L, Wunderlich M, Hartmann W, Linnemann L, Huber TB, Krebs CF, Panzer U, Locksley RM, Wilhelm C, Breloer M, Turner JE 2023-09-29
PubMed
Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD 2023-09-22
PubMed
Immune treatment tackles chronic obstructive pulmonary disease.
Fahy JV, Locksley RM 2023-09-01
PubMed
Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.
Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB 2023-04-28
PubMed
The ins and outs of innate and adaptive type 2 immunity.
Molofsky AB, Locksley RM 2023-04-11
PubMed
Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage.
Kotas ME, O'Leary CE, Locksley RM 2022-11-09
PubMed
Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM 2022-08-30
PubMed
IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.
Kotas ME, Moore CM, Gurrola JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED 2022-07-08
PubMed
Bile acid-sensitive tuft cells regulate biliary neutrophil influx.
O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM 2022-03-04
PubMed
ILC2s - development, divergence, dispersal.
Ricardo-Gonzalez RR, Molofsky AB, Locksley RM 2022-02-14
PubMed
Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB 2022-02-08
PubMed
Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS 2021-10-15
PubMed
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth.
Gschwend J, Sherman SPM, Ridder F, Feng X, Liang HE, Locksley RM, Becher B, Schneider C 2021-08-25
PubMed
CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM 2021-07-21
PubMed
Corrections.
O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C 2021-07-01
PubMed
A role for IL-33-activated ILC2s in eosinophilic vasculitis.
Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B 2021-06-22
PubMed
A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression.
Kastenschmidt JM, Coulis G, Farahat PK, Pham P, Rios R, Cristal TT, Mannaa AH, Ayer RE, Yahia R, Deshpande AA, Hughes BS, Savage AK, Giesige CR, Harper SQ, Locksley RM, Mozaffar T, Villalta SA 2021-04-13
PubMed
Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo Manipulations.
O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C 2021-03-01
PubMed
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA 2021-02-03
PubMed
In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.
Zeis P, Lian M, Fan X, Herman JS, Hernandez DC, Gentek R, Elias S, Symowski C, Knöpper K, Peltokangas N, Friedrich C, Doucet-Ladeveze R, Kabat AM, Locksley RM, Voehringer D, Bajenoff M, Rudensky AY, Romagnani C, Grün D, Gasteiger G 2020-09-30
PubMed
Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.
Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM 2020-04-06
PubMed
Tissue immunity broadcasts near and far.
Molofsky AB, Locksley RM 2020-02-01
PubMed
Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates.
Barad BA, Liu L, Diaz RE, Basilio R, Van Dyken SJ, Locksley RM, Fraser JS 2020-01-21
PubMed
Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis.
Howe M, Bauer J, Schulze A, Kropp S, Locksley RM, Alferink J, Weighardt H, Scheu S 2019-09-07
PubMed
Regulation of immune responses by tuft cells.
Schneider C, O'Leary CE, Locksley RM 2019-09-01
PubMed
Making Asthma Crystal Clear.
Fahy JV, Locksley RM 2019-08-29
PubMed
ILC2s chew the fat.
Ricardo-Gonzalez RR, Locksley RM 2019-08-12
PubMed
Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.
Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM 2019-05-22
PubMed
Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry.
O'Leary CE, Schneider C, Locksley RM 2018-10-31
PubMed
Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.
Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD 2018-10-01
PubMed
Tissue signals imprint ILC2 identity with anticipatory function.
Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM 2018-09-10
PubMed
Innate Lymphoid Cells: 10 Years On.
Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H 2018-08-23
PubMed
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS 2018-07-18
PubMed
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J 2018-07-17
PubMed
Chitins and chitinase activity in airway diseases.
Van Dyken SJ, Locksley RM 2018-06-28
PubMed
Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.
Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD 2018-06-27
PubMed
Why Innate Lymphoid Cells?
Kotas ME, Locksley RM 2018-06-19
PubMed
A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.
Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM 2018-06-07
PubMed
Pulmonary neuroendocrine cells amplify allergic asthma responses.
Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X 2018-03-29
PubMed
Perinatal Licensing of Thermogenesis by IL-33 and ST2.
Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A 2017-12-14
PubMed
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM 2017-11-09
PubMed
Turning the light on.
Locksley R 2017-07-31
PubMed
The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine.
Savage AK, Liang HE, Locksley RM 2017-07-26
PubMed
Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.
Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR 2017-05-11
PubMed
Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM 2017-04-20
PubMed
Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.
von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM 2016-12-23
PubMed
Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.
Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL 2016-12-15
PubMed
A tissue checkpoint regulates type 2 immunity.
Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM 2016-10-17
PubMed
Perinatal Licensing of Thermogenesis by IL-33 and ST2.
Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A 2016-07-21
PubMed
Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.
Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD 2016-07-07
PubMed
Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.
Gordon ED, Locksley RM, Fahy JV 2016-05-01
PubMed
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.
von Moltke J, Ji M, Liang HE, Locksley RM 2015-12-14
PubMed
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM 2015-07-01
PubMed
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.
Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM 2015-06-16
PubMed
Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation.
Molofsky AB, Savage AK, Locksley RM 2015-06-16
PubMed
New blood: Creative funding of disease-specific research.
Seaman WE, Locksley RM, Welsh MJ 2015-05-20
PubMed
Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.
Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D 2015-04-10
PubMed
IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.
Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM 2015-03-16
PubMed
A novel model for IFN-γ-mediated autoinflammatory syndromes.
Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM 2015-01-30
PubMed
Activated type 2 innate lymphoid cells regulate beige fat biogenesis.
Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A 2014-12-24
PubMed
Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.
Bando JK, Liang HE, Locksley RM 2014-12-15
PubMed
Allergic inflammation--innately homeostatic.
Cheng LE, Locksley RM 2014-11-20
PubMed
Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.
Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA 2014-10-16
PubMed
I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis.
von Moltke J, Locksley RM 2014-10-13
PubMed
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.
Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A 2014-06-05
PubMed
Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.
Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD 2014-06-02
PubMed
Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.
O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP 2014-05-19
PubMed
Asthma and the flu: a tricky two-step.
Locksley RM, Fahy JV 2014-04-01
PubMed
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM 2014-03-13
PubMed
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.
Hams E, Locksley RM, McKenzie AN, Fallon PG 2013-10-28
PubMed
Type 2 innate lymphoid cells control eosinophil homeostasis.
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM 2013-09-15
PubMed
Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung.
Bando JK, Nussbaum JC, Liang HE, Locksley RM 2013-08-07
PubMed
Traumatic brain injury induces macrophage subsets in the brain.
Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE 2013-06-05
PubMed
Eosinophils secrete IL-4 to facilitate liver regeneration.
Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A 2013-05-28
PubMed
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A 2013-04-11
PubMed
Raggin' on T-bet.
Locksley RM 2013-04-02
PubMed
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM 2013-02-18
PubMed
Innate lymphoid cells--a proposal for uniform nomenclature.
Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E 2013-02-01
PubMed
Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse.
Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR 2013-01-21
PubMed
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease.
Van Dyken SJ, Locksley RM 2013-01-03
PubMed
Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.
Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM 2013-01-03
PubMed
Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.
Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF 2012-08-31
PubMed
Marking and quantifying IL-17A-producing cells in vivo.
Price AE, Reinhardt RL, Liang HE, Locksley RM 2012-06-29
PubMed
Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF 2012-05-14
PubMed
Infectious (Non)tolerance--frustrated commensalism gone awry?
Nussbaum JC, Locksley RM 2012-05-01
PubMed
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.
Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM 2011-12-04
PubMed
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.
Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A 2011-11-20
PubMed
Deletion of Syk in neutrophils prevents immune complex arthritis.
Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA 2011-09-14
PubMed
A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness.
Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV 2011-08-22
PubMed
The airway epithelium as a regulator of Th2 responses in asthma.
Fahy JV, Locksley RM 2011-08-15
PubMed
Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.
Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM 2011-08-08
PubMed
Genetic analysis of basophil function in vivo.
Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM 2011-05-08
PubMed
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM 2011-03-24
PubMed
Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.
Svensson M, Bell L, Little MC, DeSchoolmeester M, Locksley RM, Else KJ 2011-01-01
PubMed
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.
Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A 2010-12-13
PubMed
Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes.
Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW 2010-10-27
PubMed
Lymphocyte development requires S-nitrosoglutathione reductase.
Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, Liu L 2010-10-27
PubMed
Murine B cells regulate serum IgE levels in a CD23-dependent manner.
Cheng LE, Wang ZE, Locksley RM 2010-09-24
PubMed
Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM 2010-06-07
PubMed
Asthma and allergic inflammation.
Locksley RM 2010-03-19
PubMed
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands.
Barbalat R, Lau L, Locksley RM, Barton GM 2009-10-04
PubMed
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B 2009-08-13
PubMed
Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates.
Voehringer D, Wu D, Liang HE, Locksley RM 2009-07-28
PubMed
Nine lives: plasticity among T helper cell subsets.
Locksley RM 2009-07-27
PubMed
In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli.
Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A 2009-06-01
PubMed
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway.
Kroeger KM, Sullivan BM, Locksley RM 2009-05-18
PubMed
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG 2009-05-12
PubMed
Cytokine-secreting follicular T cells shape the antibody repertoire.
Reinhardt RL, Liang HE, Locksley RM 2009-03-01
PubMed
The inflammasome and alum-mediated adjuvanticity.
Kang SJ, Locksley RM 2009-02-24
PubMed
Basophils: a nonredundant contributor to host immunity.
Sullivan BM, Locksley RM 2009-01-16
PubMed
Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo.
Scheu S, Dresing P, Locksley RM 2008-12-16
PubMed
Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
Kang SJ, Liang HE, Reizis B, Locksley RM 2008-11-14
PubMed
Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL 2008-10-15
PubMed
Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration.
Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM 2008-10-15
PubMed
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B 2008-10-03
PubMed
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.
Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH 2008-06-26
PubMed
Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice.
Voehringer D, Liang HE, Locksley RM 2008-04-01
PubMed
The Roaring Twenties.
Locksley RM 2008-04-01
PubMed
Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity.
Van Dyken SJ, Locksley RM 2007-10-02
PubMed
Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M 2007-08-03
PubMed
A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes.
Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C 2007-07-15
PubMed
Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major.
Launois P, Pingel S, Himmelrich H, Locksley R, Louis J 2007-05-27
PubMed
Chitin induces accumulation in tissue of innate immune cells associated with allergy.
Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM 2007-04-22
PubMed
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.
Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM 2007-03-11
PubMed
Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.
Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley RM 2007-03-06
PubMed
Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages.
Voehringer D, van Rooijen N, Locksley RM 2007-03-05
PubMed
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH 2006-12-11
PubMed
A failure to launch: fuelling cytokine secretion in iNKT cells.
Locksley RM 2006-09-01
PubMed
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA 2006-08-01
PubMed
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM 2006-08-01
PubMed
LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major.
Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J 2006-06-01
PubMed
Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.
Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM 2006-05-15
PubMed
Activation of the integrated stress response during T helper cell differentiation.
Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM 2006-05-07
PubMed
Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence.
Hayashida T, Oda M, Ohsawa K, Yamaguchi A, Hosozawa T, Locksley RM, Giacca M, Masai H, Miyatake S 2006-05-01
PubMed
T helper cell effector fates--who, how and where?
Reinhardt RL, Kang SJ, Liang HE, Locksley RM 2006-04-17
PubMed
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B 2006-02-01
PubMed
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA 2005-11-27
PubMed
Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds.
Im W, Kim H, Yun D, Seo SY, Park SH, Locksley RM, Hong S 2005-10-31
PubMed
A two-step process for cytokine production revealed by IL-4 dual-reporter mice.
Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M 2005-10-01
PubMed
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.
Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP 2005-07-01
PubMed
Interleukin-4 can be a key positive regulator of inflammatory arthritis.
Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C 2005-06-01
PubMed
The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice.
Kelly BL, Locksley RM 2004-12-01
PubMed
CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.
Voehringer D, Rosen DB, Lanier LL, Locksley RM 2004-10-07
PubMed
Innate immune responses in peptidoglycan recognition protein L-deficient mice.
Xu M, Wang Z, Locksley RM 2004-09-01
PubMed
Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production.
Voehringer D, Shinkai K, Locksley RM 2004-03-01
PubMed
Th2 cells: orchestrating barrier immunity.
Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM 2004-01-01
PubMed
Basal chromatin modification at the IL-4 gene in helper T cells.
Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley RM 2003-12-15
PubMed
Leishmania major LACK antigen is required for efficient vertebrate parasitization.
Kelly BL, Stetson DB, Locksley RM 2003-12-01
PubMed
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.
Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM 2003-10-06
PubMed
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.
Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M 2003-06-26
PubMed
Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity.
Hadeiba H, Locksley RM 2003-06-01
PubMed
Stat signals release activated naive Th cells from an anergic checkpoint.
Mohrs M, Lacy DA, Locksley RM 2003-02-15
PubMed
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA 2003-01-13
PubMed
Helper T cells regulate type-2 innate immunity in vivo.
Shinkai K, Mohrs M, Locksley RM 2002-12-01
PubMed
Blood lines.
Locksley RM 2002-08-01
PubMed
Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.
Stetson DB, Mohrs M, Mallet-Designe V, Teyton L, Locksley RM 2002-08-01
PubMed
T helper cell differentiation: on again, off again.
Grogan JL, Locksley RM 2002-06-01
PubMed
Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in non
Launois P, Gumy A, Himmelrich H, Locksley RM, Röcken M, Louis JA 2002-05-01
PubMed
Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection.
Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D 2002-04-01
PubMed
Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.
Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA 2001-12-01
PubMed
Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.
Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH 2001-11-09
PubMed
Deletion of a coordinate regulator of type 2 cytokine expression in mice.
Mohrs M, Blankespoor CM, Wang ZE, Loots GG, Afzal V, Hadeiba H, Shinkai K, Rubin EM, Locksley RM 2001-09-01
PubMed
Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter.
Mohrs M, Shinkai K, Mohrs K, Locksley RM 2001-08-01
PubMed
Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis.
Bottrel RL, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Netto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ 2001-05-01
PubMed
Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice.
Maillard I, Launois P, Himmelrich H, Acha-Orbea H, Diggelmann H, Locksley RM, Louis JA 2001-04-01
PubMed
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.
Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM 2001-03-01
PubMed
The TNF and TNF receptor superfamilies: integrating mammalian biology.
Locksley RM, Killeen N, Lenardo MJ 2001-02-23
PubMed
Flying doctors.
Locksley RM 2000-12-01
PubMed
Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns.
Kelly BL, Locksley RM 2000-09-15
PubMed
Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells.
Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA 2000-07-15
PubMed
Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system.
Hadeiba H, Corry DB, Locksley RM 2000-05-01
PubMed
Faithful expression of the human 5q31 cytokine cluster in transgenic mice.
Lacy DA, Wang ZE, Symula DJ, McArthur CJ, Rubin EM, Frazer KA, Locksley RM 2000-05-01
PubMed
In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease.
Himmelrich H, Launois P, Maillard I, Biedermann T, Tacchini-Cottier F, Locksley RM, Röcken M, Louis JA 2000-05-01
PubMed
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.
Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA 2000-04-07
PubMed
CD1, tuberculosis, and the evolution of major histocompatibility complex molecules.
Shinkai K, Locksley RM 2000-03-20
PubMed
Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).
Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N 1999-12-15
PubMed
Functional screening of an asthma QTL in YAC transgenic mice.
Symula DJ, Frazer KA, Ueda Y, Denefle P, Stevens ME, Wang ZE, Locksley R, Rubin EM 1999-10-01
PubMed
Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.
Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM 1999-10-01
PubMed
Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases.
Fowell DJ, Locksley RM 1999-06-01
PubMed
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.
Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM 1999-04-05
PubMed
Susceptibility to infectious diseases: Leishmania as a paradigm.
Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ 1999-03-01
PubMed
Construction of polycompetitors for competitive PCR.
Corry DB, Locksley RM 1999-01-01
PubMed
Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism.
Bix M, Wang ZE, Thiel B, Schork NJ, Locksley RM 1998-12-21
PubMed
Requirement for IL-13 independently of IL-4 in experimental asthma.
Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB 1998-12-18
PubMed
Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.
Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM 1998-11-02
PubMed
Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.
Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM 1998-09-01
PubMed
Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells.
Bix M, Locksley RM 1998-08-28
PubMed
Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors.
Joiner KA, Powderly WG, Blaser MJ, Klempner MS, Locksley RM, Mandell GL, Preheim LC, Remington JS, Slama TG, Steigbigel NH, Bartlett JG 1998-05-01
PubMed
Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.
Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM 1998-05-01
PubMed
Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets.
Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M 1998-04-15
PubMed
Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
Pingel S, Wang ZE, Locksley RM 1998-04-01
PubMed
Macromolecular contrast media-enhanced MRI estimates of microvascular permeability correlate with histopathologic tumor grade.
Brasch RC, Daldrup H, Shames D, Wendland M, Okuhata Y, Rosenau W 1998-04-01
PubMed
Control of Leishmania major by a monoclonal alpha beta T cell repertoire.
Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM 1998-01-15
PubMed
Development of CD4+ effector T cells and susceptibility to infectious diseases.
Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M 1998-01-01
PubMed
Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells.
McSorley SJ, Soldera S, Malherbe L, Carnaud C, Locksley RM, Flavell RA, Glaichenhaus N 1997-09-01
PubMed
Altered immune responses in interleukin 10 transgenic mice.
Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M 1997-06-16
PubMed
IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice.
Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA 1997-05-01
PubMed
Impaired Th2 subset development in the absence of CD4.
Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM 1997-05-01
PubMed
The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.
Stevenson FT, Turck J, Locksley RM, Lovett DH 1997-01-21
PubMed
T helper subset differentiation in the absence of invariant chain.
Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL 1997-01-06
PubMed
Exploitation of immune and other defence mechanisms by parasites: an overview.
Locksley RM 1997-01-01
PubMed
Leishmania major: targeting IL-4 in successful immunomodulation of murine infection.
Wakil AE, Wang ZE, Locksley RM 1996-11-01
PubMed
Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.
Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL 1996-10-01
PubMed
Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis.
Corry DB, Ampel NM, Christian L, Locksley RM, Galgiani JN 1996-08-01
PubMed
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.
Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ 1996-08-01
PubMed
The instructive role of innate immunity in the acquired immune response.
Fearon DT, Locksley RM 1996-04-05
PubMed
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM 1996-01-01
PubMed
Interleukin-12 in murine leishmaniasis--match, flame or fuel?
Fowell DJ, Wakil AE, Locksley RM 1995-09-01
PubMed
Natural T cells. Cells that co-express NKRP-1 and TCR.
Bix M, Locksley RM 1995-08-01
PubMed
Expression cloning of a protective Leishmania antigen.
Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N 1995-04-28
PubMed
The development of effector T cell subsets in murine Leishmania major infection.
Locksley RM, Wakil AE, Corry DB, Pingel S, Bix M, Fowell DJ 1995-01-01
PubMed
The regulation of immunity to Leishmania major.
Reiner SL, Locksley RM 1995-01-01
PubMed
Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.
Wang ZE, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM 1994-12-20
PubMed
Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.
Corry DB, Reiner SL, Linsley PS, Locksley RM 1994-11-01
PubMed
Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46; 173(1994) 133).
Reiner SL, Zheng S, Corry DB, Locksley RM 1994-10-14
PubMed
Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46).
Reiner SL, Zheng S, Corry DB, Locksley RM 1994-07-12
PubMed
Th2 cells: help for helminths.
Locksley RM 1994-05-01
PubMed
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.
Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM 1994-04-01
PubMed
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.
Reiner SL, Zheng S, Wang ZE, Stowring L, Locksley RM 1994-02-01
PubMed
Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis.
Reiner SL, Locksley RM 1993-12-01
PubMed
Potential role for interleukin-10 in the immunosuppression associated with kala azar.
Holaday BJ, Pompeu MM, Jeronimo S, Texeira MJ, Sousa Ade A, Vasconcelos AW, Pearson RD, Abrams JS, Locksley RM 1993-12-01
PubMed
Constructing polycompetitor cDNAs for quantitative PCR.
Reiner SL, Zheng S, Corry DB, Locksley RM 1993-09-27
PubMed
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N 1993-09-10
PubMed
Reconstitution of Mycobacterium leprae immunity in severe combined immunodeficient mice using a T-cell line.
Azouaou N, Gelber RH, Abel K, Sasaki DT, Murray LP, Locksley RM, Mohagheghpour N 1993-09-01
PubMed
Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis.
Wang ZE, Reiner SL, Hatam F, Heinzel FP, Bouvier J, Turck CW, Locksley RM 1993-08-15
PubMed
The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.
Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH 1993-08-01
PubMed
Interleukin 12 in host defense against microbial pathogens.
Locksley RM 1993-07-01
PubMed
The worm and the protozoa: stereotyped responses or distinct antigens?
Reiner SL, Locksley RM 1993-07-01
PubMed
Transfected Leishmania expressing biologically active IFN-gamma.
Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM 1993-06-01
PubMed
IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.
Heinzel FP, Rerko RM, Hatam F, Locksley RM 1993-05-01
PubMed
TH1 and TH2 cell antigen receptors in experimental leishmaniasis.
Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM 1993-03-05
PubMed
Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.
Stevenson FT, Bursten SL, Locksley RM, Lovett DH 1992-10-01
PubMed
Immunology of leishmaniasis.
Locksley RM, Louis JA 1992-08-01
PubMed
Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms.
Stevenson FT, Torrano F, Locksley RM, Lovett DH 1992-08-01
PubMed
Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice.
Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH 1992-04-16
PubMed
Lessons from Leishmania: a model for investigations of CD4+ subset differentiation.
Reiner SL, Locksley RM 1992-02-01
PubMed
Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice.
Sadick MD, Street N, Mosmann TR, Locksley RM 1991-12-01
PubMed
Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.
Holaday BJ, Sadick MD, Wang ZE, Reiner SL, Heinzel FP, Parslow TG, Locksley RM 1991-09-01
PubMed
Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.
Heinzel FP, Sadick MD, Mutha SS, Locksley RM 1991-08-15
PubMed
Activation of human monocyte--derived macrophages with lipopolysaccharide decreases human immunodeficiency virus replication in vitro at the level of gene expression.
Bernstein MS, Tong-Starksen SE, Locksley RM 1991-08-01
PubMed
A single peptide from the major outer membrane protein of Chlamydia trachomatis elicits T cell help for the production of antibodies to protective determinants.
Allen JE, Locksley RM, Stephens RS 1991-07-15
PubMed
Cytokines in fluids from polycystic kidneys.
Gardner KD, Burnside JS, Elzinga LW, Locksley RM 1991-04-01
PubMed
Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function.
Locksley RM, Scott P 1991-03-01
PubMed
Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection.
Locksley RM, Heinzel FP, Holaday BJ, Mutha SS, Reiner SL, Sadick MD 1991-01-01
PubMed
Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.
Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM 1990-01-01
PubMed
The exposure of health care workers to ribavirin aerosol.
Guglielmo BJ, Jacobs RA, Locksley RM 1989-04-07
PubMed
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.
Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM 1989-01-01
PubMed
Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo.
Locksley RM, Crowe S, Sadick MD, Heinzel FP, Gardner KD, McGrath MS, Mills J 1988-12-01
PubMed
Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors.
Bursten SL, Locksley RM, Ryan JL, Lovett DH 1988-11-01
PubMed
Fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient.
Hamadeh R, Ardehali A, Locksley RM, York MK 1988-08-01
PubMed
Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice.
Heinzel FP, Sadick MD, Locksley RM 1988-04-01
PubMed
Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote.
Locksley RM, Heinzel FP, Fankhauser JE, Nelson CS, Sadick MD 1988-02-01
PubMed
Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells.
Locksley RM, Heinzel FP, Shepard HM, Agosti J, Eessalu TE, Aggarwal BB, Harlan JM 1987-09-15
PubMed
Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets.
Locksley RM, Heinzel FP, Sadick MD, Holaday BJ, Gardner KD 1987-09-01
PubMed
Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.
Sadick MD, Heinzel FP, Shigekane VM, Fisher WL, Locksley RM 1987-08-15
PubMed
Loss of granule myeloperoxidase during in vitro culture of human monocytes correlates with decay in antiprotozoa activity.
Locksley RM, Nelson CS, Fankhauser JE, Klebanoff SJ 1987-05-01
PubMed
Isolation and characterization of the receptor on human neutrophils that mediates cellular adherence.
Hickstein DD, Ozols J, Williams SA, Baenziger JU, Locksley RM, Roth GJ 1987-04-25
PubMed
Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells.
Hickstein DD, Smith A, Fisher W, Beatty PG, Schwartz BR, Harlan JM, Root RK, Locksley RM 1987-01-15
PubMed
Monoclonal antibodies binding to the human neutrophil C3bi receptor have disparate functional effects.
Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK 1986-04-01
PubMed
Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro.
Sadick MD, Locksley RM, Tubbs C, Raff HV 1986-01-01
PubMed
Infection with varicella-zoster virus after marrow transplantation.
Locksley RM, Flournoy N, Sullivan KM, Meyers JD 1985-12-01
PubMed
Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii.
Locksley RM, Fankhauser J, Henderson WR 1985-10-01
PubMed
Development of cellular immunity in cutaneous leishmaniasis due to Leishmania tropica.
Sadick MD, Locksley RM, Raff HV 1984-07-01
PubMed
Interaction of primate alveolar macrophages and Legionella pneumophila.
Jacobs RF, Locksley RM, Wilson CB, Haas JE, Klebanoff SJ 1984-06-01
PubMed
Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood-brain barrier.
Ryser RJ, Locksley RM, Eng SC, Dobbins WO, Schoenknecht FD, Rubin CE 1984-04-01
PubMed
Increased respiratory burst in myeloperoxidase-deficient monocytes.
Locksley RM, Wilson CB, Klebanoff SJ 1983-10-01
PubMed
Oxidative response of phagocytes to parasite invasion.
Klebanoff SJ, Locksley RM, Jong EC, Rosen H 1983-01-01
PubMed
Oxygen-dependent microbicidal systems of phagocytes and host defense against intracellular protozoa.
Locksley RM, Klebanoff SJ 1983-01-01
PubMed
Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems.
Locksley RM, Jacobs RF, Wilson CB, Weaver WM, Klebanoff SJ 1982-11-01
PubMed
Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection.
Locksley RM, Cohen ML, Quinn TC, Tompkins LS, Coyle MB, Kirihara JM, Counts GW 1982-09-01
PubMed
Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes.
Locksley RM, Wilson CB, Klebanoff SJ 1982-05-01
PubMed
Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients.
Ashraf N, Locksley R, Arieff AI 1981-06-01
PubMed
Prognostic grading and significance of ventricular premature beats after recovery from myocardial infarction.
Moss AJ, DeCamilla J, Mietlowski W, Greene WA, Goldstein S, Locksley R 1975-12-01
PubMed
Two improvements in the preparation of cardiac microsomes.
Stam AC, Sole M, Locksley R, Weglicki WB, Sonnenblick EH 1974-01-01
PubMed
