University of California San Francisco

Harold Chapman, MD

harold.chapman
Harold Chapman, MD

Professor, Medicine
School of Medicine
 

Address

513 Parnassus Avenue HSE, #201A
San Francisco, CA 94143
United States

Email: [email protected]

Education

Institution Degree Dept or School End Date
University of Utah Internal Medicine and Pulmonary Critical Care 06/80
University of Alabama Schooll of Medicine MD Medicine 06/72

Awards & Honors

Award Conferred By Date
Merit Award National Institute of Health 2001/2012
American Association of Physicians 1998
American Society for Clinical Investigation 1987

Grants and Funding

  • Program to promote lung regeneration and block fibrosis | NIH | 2020-02-15 - 2027-01-31 | Role: Principal Investigator
  • Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage | NIH | 2016-09-21 - 2023-05-31 | Role: Principal Investigator
  • Epithelial Stem/Progenitor Cells in Repair of the Injured Lung | NIH | 2015-07-15 - 2020-04-30 | Role: Principal Investigator
  • LOXL-2 dependent blockade of TGF Beta1 signaling and lung fibrosis | NIH | 2019-02-01 - 2020-01-31 | Role: Principal Investigator
  • Targeting epithelial cells to treat pulmonary fibrosis | NIH | 2012-08-09 - 2018-07-31 | Role: Co-Investigator
  • Epithelial Progenitor Cells in Lung Repair and Regeneration | NIH | 2012-01-01 - 2016-12-31 | Role: Principal Investigator
  • Epithelial Mesenchymal Transition in Pulmonary Fibrosis | NIH | 1991-01-01 - 2014-12-31 | Role: Principal Investigator
  • Urokinase Receptor Integrin Interactions in Lung Cancer | NIH | 2007-07-01 - 2013-05-31 | Role: Principal Investigator
  • Role of Elastolytic Cathepsins in Emphysema | NIH | 2001-06-01 - 2012-05-31 | Role: Principal Investigator
  • Identification, Isolation, and Reprogramming Alveolar Epithelial Progenitor Cells | NIH | 2008-12-01 - 2009-05-31 | Role: Principal Investigator
  • Cysteine Proteases in MHC Class II Antigen Presentation | NIH | 1993-01-01 - 2007-12-31 | Role: Principal Investigator
  • CATHEPSIN S AND ALZHEIMERS DISEASE | NIH | 1995-08-20 - 1998-07-31 | Role: Principal Investigator
  • INTERACTION OF HUMAN ALVEOLAR MACROPHAGES WIH FIBRIN | NIH | 1985-09-30 - 1989-03-31 | Role: Principal Investigator
  • ROLE OF HUMAN ALVEOLAR MACROPHAGES IN EMPHYSEMA | NIH | 1985-12-01 - 1988-06-30 | Role: Principal Investigator
  • ROLE OF HUMAN ALVEOLAR MACROPHAGES IN EMPHYSEMA | NIH | 1985-07-01 - 1985-08-31 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 172
  1. Alveolar Type II Cell-derived MMP1 high basal cells promote destructive microcysts in idiopathic pulmonary fibrosis.
    Garakani K, Brumwell AN, Toigo M, Jacob A, Wei Y, Ho TC, Wolters PJ, Matthay MA, Volk R, Zaro B, Iantorno S, Mitke A, Sheppard D, Auyeung V, Jourdan Le Saux C, Chapman HA| | PubMed
  2. A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis.
    Cohen ML, Brumwell AN, Ho TC, Garakani K, Montas G, Leong D, Ding VW, Golden JA, Trinh BN, Jablons DM, Matthay MA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ| | PubMed
  3. BCL-2 Modulates IRE1α Activation to Attenuate Endoplasmic Reticulum Stress and Pulmonary Fibrosis.
    Le Saux CJ, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA| | PubMed
  4. A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis.
    Cohen ML, Brumwell AN, Che Ho T, Montas G, Golden JA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ| | PubMed
  5. Human distal airways contain a multipotent secretory cell that can regenerate alveoli.
    Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE| | PubMed
  6. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
    Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T| | PubMed
  7. Nuclear IL-33 as a growth and survival agent within basal cells.
    Chapman HA| | PubMed
  8. Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity.
    Bota-Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, Tan X, Sheng K, Ahn YH, Lee S, Parra ER, Rodriguez-Canales J, Albritton J, Weiger M, Liu X, Guo HF, Yu J, Rodriguez BL, Firestone JJA, Mino B, Creighton CJ, Solis LM, Villalobos P, Raso MG, Sazer DW, Gibbons DL, Russell WK, Longmore GD, Wistuba II, Wang J, Chapman HA, Miller JS, Zong C, Kurie JM| | PubMed
  9. Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis.
    Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA| | PubMed
  10. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion.
    Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL| | PubMed
  11. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.
    Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O'Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB| | PubMed
  12. Reversal of TGFβ1-Driven Profibrotic State in Patients with Pulmonary Fibrosis.
    Chapman HA, Wei Y, Montas G, Leong D, Golden JA, Trinh BN, Wolters PJ, Le Saux CJ, Jones KD, Hills NK, Foster E, Oldham JM, Linderholm AL, Kotak P, Decaris M, Turner S, Song JW| | PubMed
  13. VEGF Drives the Car toward Better Gas Exchange.
    Kathiriya JJ, Chapman HA| | PubMed
  14. Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration.
    Kathiriya JJ, Brumwell AN, Jackson JR, Tang X, Chapman HA| | PubMed
  15. Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis.
    Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, Alimirah F, Castellanos CA, Ruan R, Wei Y, Chapman HA, Ramanathan A, Campisi J, Jourdan Le Saux C| | PubMed
  16. B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes.
    Egia-Mendikute L, Arpa B, Rosell-Mases E, Corral-Pujol M, Carrascal J, Carrillo J, Mora C, Chapman H, Panosa A, Vives-Pi M, Stratmann T, Serreze D, Verdaguer J| | PubMed
  17. Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.
    LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y| | PubMed
  18. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
    Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR| | PubMed
  19. Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited.
    Le Saux CJ, Chapman HA| | PubMed
  20. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
    Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T| | PubMed
  21. TGF-β1 Signaling and Tissue Fibrosis.
    Kim KK, Sheppard D, Chapman HA| | PubMed
  22. Extracellular matrix in lung development, homeostasis and disease.
    Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ| | PubMed
  23. Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.
    Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA| | PubMed
  24. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.
    Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE| | PubMed
  25. Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.
    McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL| | PubMed
  26. Failure of Alveolar Type 2 Cell Maintenance Links Neonatal Distress with Adult Lung Disease.
    Vaughan AE, Chapman HA| | PubMed
  27. Persistent Pathology in Influenza-Infected Mouse Lungs.
    Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR| | PubMed
  28. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.
    Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA| | PubMed
  29. Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling.
    Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R| | PubMed
  30. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
    Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE| | PubMed
  31. Soluble urokinase-type plasminogen activator receptor in FSGS: stirred but not shaken.
    Reiser J, Chapman H| | PubMed
  32. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts.
    Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA| | PubMed
  33. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.
    Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP| | PubMed
  34. Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline.
    Xi Y, Tan K, Brumwell AN, Chen SC, Kim YH, Kim TJ, Wei Y, Chapman HA| | PubMed
  35. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.
    Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS| | PubMed
  36. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins.
    Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK| | PubMed
  37. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.
    Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ| | PubMed
  38. Molecular determinants of lung development.
    Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS| | PubMed
  39. Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.
    Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grötzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M| | PubMed
  40. Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.
    Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA| | PubMed
  41. Regenerative activity of the lung after epithelial injury.
    Vaughan AE, Chapman HA| | PubMed
  42. Epithelial responses to lung injury: role of the extracellular matrix.
    Chapman HA| | PubMed
  43. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors.
    Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald DM| | PubMed
  44. Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis.
    Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA| | PubMed
  45. Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice.
    Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH| | PubMed
  46. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.
    Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D| | PubMed
  47. Toward lung regeneration.
    Chapman HA| | PubMed
  48. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.
    Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ| | PubMed
  49. Epithelial-mesenchymal interactions in pulmonary fibrosis.
    Chapman HA| | PubMed
  50. Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins.
    Zhu S, Gladson CL, White KE, Ding Q, Stewart J, Jin TH, Chapman HA, Olman MA| | PubMed
  51. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis.
    Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney ZX, Taglienti M, Bates CM, Chapman HA, Miner JH, Kreidberg JA| | PubMed
  52. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts.
    Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, Chapman HA| | PubMed
  53. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.
    Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA| | PubMed
  54. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins.
    Tang CH, Hill ML, Brumwell AN, Chapman HA, Wei Y| | PubMed
  55. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.
    Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM| | PubMed
  56. Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis.
    Kim KK, Chapman HA| | PubMed
  57. Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells.
    Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA| | PubMed
  58. Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.
    Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP| | PubMed
  59. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.
    Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA| | PubMed
  60. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice.
    Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ| | PubMed
  61. The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
    DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK| | PubMed
  62. Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.
    Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS| | PubMed
  63. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease.
    Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA| | PubMed
  64. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors.
    Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R, Shi GP| | PubMed
  65. The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
    Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK| | PubMed
  66. Endosomal proteases in antigen presentation.
    Chapman HA| | PubMed
  67. Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.
    Kala M, Chen CR, McLachlan SM, Rapoport B, Aliesky H, Chapman HA| | PubMed
  68. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease.
    Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, Stoler J, Reilly JJ, Chapman HA, Speizer FE, Weiss ST, Mecham RP, Raby BA| | PubMed
  69. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.
    Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Desanctis G, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA| | PubMed
  70. Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis.
    Yang H, Kala M, Scott BG, Goluszko E, Chapman HA, Christadoss P| | PubMed
  71. Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.
    Wei Y, Czekay RP, Robillard L, Kugler MC, Zhang F, Kim KK, Xiong JP, Humphries MJ, Chapman HA| | PubMed
  72. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.
    Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP| | PubMed
  73. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions.
    Aslanian AM, Chapman HA, Charo IF| | PubMed
  74. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease.
    DeMeo DL, Celedón JC, Lange C, Reilly JJ, Chapman HA, Sylvia JS, Speizer FE, Weiss ST, Silverman EK| | PubMed
  75. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice.
    Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP| | PubMed
  76. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).
    Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK| | PubMed
  77. Cathepsins as transcriptional activators?
    Chapman HA| | PubMed
  78. Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD.
    DeMeo DL, Carey VJ, Chapman HA, Reilly JJ, Ginns LC, Speizer FE, Weiss ST, Silverman EK| | PubMed
  79. Proteases, extracellular matrix, and cancer: a workshop of the path B study section.
    DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M| | PubMed
  80. Disorders of lung matrix remodeling.
    Chapman HA| | PubMed
  81. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact.
    Zhang F, Tom CC, Kugler MC, Ching TT, Kreidberg JA, Wei Y, Chapman HA| | PubMed
  82. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5.
    Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G| | PubMed
  83. Matrilysin-dependent elastolysis by human macrophages.
    Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA, Shapiro S, Weiss SJ| | PubMed
  84. Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease.
    Palmer LJ, Celedón JC, Chapman HA, Speizer FE, Weiss ST, Silverman EK| | PubMed
  85. Deficiency of the cysteine protease cathepsin S impairs microvessel growth.
    Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P| | PubMed
  86. Urokinase receptor and integrin interactions.
    Kugler MC, Wei Y, Chapman HA| | PubMed
  87. The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease.
    Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS| | PubMed
  88. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.
    Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA| | PubMed
  89. The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen.
    Wu ZQ, Shen Y, Khan AQ, Chu CL, Riese R, Chapman HA, Kanagawa O, Snapper CM| | PubMed
  90. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.
    Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH| | PubMed
  91. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease.
    Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST| | PubMed
  92. Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes.
    Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST| | PubMed
  93. Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human lung fibroblasts.
    Zhu S, Gladson CL, Stewart J, White KE, Chapman HA, Olman MA| | PubMed
  94. Random peptide bacteriophage display as a probe for urokinase receptor ligands.
    Fong S, Doyle MV, Goodson RJ, Drummond RJ, Stratton JR, McGuire L, Doyle LV, Chapman HA, Rosenberg S| | PubMed
  95. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.
    Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA| | PubMed
  96. Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.
    Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA| | PubMed
  97. Protease crosstalk with integrins: the urokinase receptor paradigm.
    Chapman HA, Wei Y| | PubMed
  98. Expression of cathepsins B and S in the progression of prostate carcinoma.
    Fernández PL, Farré X, Nadal A, Fernández E, Peiró N, Sloane BF, Shi GP, Chapman HA, Campo E, Cardesa A| | PubMed
  99. Interferon gamma induction of pulmonary emphysema in the adult murine lung.
    Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA| | PubMed
  100. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease.
    Silverman EK, Weiss ST, Drazen JM, Chapman HA, Carey V, Campbell EJ, Denish P, Silverman RA, Celedon JC, Reilly JJ, Ginns LC, Speizer FE| | PubMed
  101. Importance of lysosomal cysteine proteases in lung disease.
    Wolters PJ, Chapman HA| | PubMed
  102. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.
    Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA| | PubMed
  103. Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.
    Luke C, Schick C, Tsu C, Whisstock JC, Irving JA, Brömme D, Juliano L, Shi GP, Chapman HA, Silverman GA| | PubMed
  104. Protease injury in the development of COPD: Thomas A. Neff Lecture.
    Chapman HA, Shi GP| | PubMed
  105. Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function.
    Simon DI, Wei Y, Zhang L, Rao NK, Xu H, Chen Z, Liu Q, Rosenberg S, Chapman HA| | PubMed
  106. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.
    Shi GP, Bryant RA, Riese R, Verhelst S, Driessen C, Li Z, Bromme D, Ploegh HL, Chapman HA| | PubMed
  107. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.
    Villadangos JA, Driessen C, Shi GP, Chapman HA, Ploegh HL| | PubMed
  108. Nonproteolytic role for the urokinase receptor in cellular migration in vivo.
    Waltz DA, Fujita RM, Yang X, Natkin L, Zhuo S, Gerard CJ, Rosenberg S, Chapman HA| | PubMed
  109. Cathepsins and compartmentalization in antigen presentation.
    Riese RJ, Chapman HA| | PubMed
  110. Proteases involved in MHC class II antigen presentation.
    Villadangos JA, Bryant RA, Deussing J, Driessen C, Lennon-Duménil AM, Riese RJ, Roth W, Saftig P, Shi GP, Chapman HA, Peters C, Ploegh HL| | PubMed
  111. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.
    Driessen C, Bryant RA, Lennon-Duménil AM, Villadangos JA, Bryant PW, Shi GP, Chapman HA, Ploegh HL| | PubMed
  112. Cystatin C deficiency in human atherosclerosis and aortic aneurysms.
    Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA| | PubMed
  113. Role of urokinase receptor and caveolin in regulation of integrin signaling.
    Chapman HA, Wei Y, Simon DI, Waltz DA| | PubMed
  114. A Fas pathway to pulmonary fibrosis.
    Chapman HA| | PubMed
  115. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling.
    Wei Y, Yang X, Liu Q, Wilkins JA, Chapman HA| | PubMed
  116. Cathepsin S required for normal MHC class II peptide loading and germinal center development.
    Shi GP, Villadangos JA, Dranoff G, Small C, Gu L, Haley KJ, Riese R, Ploegh HL, Chapman HA| | PubMed
  117. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization.
    Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Brömme D| | PubMed
  118. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation.
    Maurer D, Fiebiger E, Reininger B, Ebner C, Petzelbauer P, Shi GP, Chapman HA, Stingl G| | PubMed
  119. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.
    Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P| | PubMed
  120. Cathepsin S activity regulates antigen presentation and immunity.
    Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA| | PubMed
  121. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis.
    Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O'DONNELL WJ, Reilly JJ, Ginns L, Mentzer S, Wain J, Speizer FE| | PubMed
  122. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.
    Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, Gornstein ER, Brömme D, Chapman HA, Silverman GA| | PubMed
  123. Endosomal proteolysis and MHC class II function.
    Chapman HA| | PubMed
  124. Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.
    Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA| | PubMed
  125. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration.
    Chapman HA| | PubMed
  126. Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism.
    Villadangos JA, Riese RJ, Peters C, Chapman HA, Ploegh HL| | PubMed
  127. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin.
    Waltz DA, Natkin LR, Fujita RM, Wei Y, Chapman HA| | PubMed
  128. Structure and chromosomal assignment of the human cathepsin K gene.
    Gelb BD, Shi GP, Heller M, Weremowicz S, Morton C, Desnick RJ, Chapman HA| | PubMed
  129. Emerging roles for cysteine proteases in human biology.
    Chapman HA, Riese RJ, Shi GP| | PubMed
  130. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells.
    Simon DI, Rao NK, Xu H, Wei Y, Majdic O, Ronne E, Kobzik L, Chapman HA| | PubMed
  131. Regulation of integrin function by the urokinase receptor.
    Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA| | PubMed
  132. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.
    Gelb BD, Shi GP, Chapman HA, Desnick RJ| | PubMed
  133. Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87).
    Wong WS, Simon DI, Rosoff PM, Rao NK, Chapman HA| | PubMed
  134. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading.
    Riese RJ, Wolf PR, Brömme D, Natkin LR, Villadangos JA, Ploegh HL, Chapman HA| | PubMed
  135. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.
    Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA| | PubMed
  136. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression.
    Rao NK, Shi GP, Chapman HA| | PubMed
  137. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
    Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ| | PubMed
  138. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.
    Shi GP, Chapman HA, Bhairi SM, DeLeeuw C, Reddy VY, Weiss SJ| | PubMed
  139. Identification of the urokinase receptor as an adhesion receptor for vitronectin.
    Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA| | PubMed
  140. The role of thiol proteases in tissue injury and remodeling.
    Chapman HA, Munger JS, Shi GP| | PubMed
  141. Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy.
    Waltz DA, Chapman HA| | PubMed
  142. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution.
    Shi GP, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA| | PubMed
  143. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.
    Levy BD, Romano M, Chapman HA, Reilly JJ, Drazen J, Serhan CN| | PubMed
  144. Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors.
    Waltz DA, Sailor LZ, Chapman HA| | PubMed
  145. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.
    Shi GP, Munger JS, Meara JP, Rich DH, Chapman HA| | PubMed
  146. A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases.
    Munger JS, Shi GP, Mark EA, Chin DT, Gerard C, Chapman HA| | PubMed
  147. Cigarette smoking induces an elastolytic cysteine proteinase in macrophages distinct from cathepsin L.
    Reilly JJ, Chen P, Sailor LZ, Wilcox D, Mason RW, Chapman HA| | PubMed
  148. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines.
    Nusrat AR, Chapman HA| | PubMed
  149. Role of enzyme receptors and inhibitors in regulating proteolytic activities of macrophages.
    Chapman HA| | PubMed
  150. Alveolar macrophage urokinase receptors localize enzyme activity to the cell surface.
    Chapman HA, Bertozzi P, Sailor LZ, Nusrat AR| | PubMed
  151. Developmental expression of plasminogen activator inhibitor type 1 by human alveolar macrophages. Possible role in lung injury.
    Chapman HA, Yang XL, Sailor LZ, Sugarbaker DJ| | PubMed
  152. Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages.
    Reilly JJ, Chen P, Sailor LZ, Mason RW, Chapman HA| | PubMed
  153. Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome.
    Bertozzi P, Astedt B, Zenzius L, Lynch K, LeMaire F, Zapol W, Chapman HA| | PubMed
  154. Identification of cystatin C, a cysteine proteinase inhibitor, as a major secretory product of human alveolar macrophages in vitro.
    Chapman HA, Reilly JJ, Yee R, Grubb A| | PubMed
  155. Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages.
    Reilly JJ, Mason RW, Chen P, Joseph LJ, Sukhatme VP, Yee R, Chapman HA| | PubMed
  156. Association between alveolar macrophage plasminogen activator activity and indices of lung function in young cigarette smokers.
    Reilly JJ, Chapman HA| | PubMed
  157. Role of enzymes mediating thrombosis and thrombolysis in lung disease.
    Chapman HA, Bertozzi P, Reilly JJ| | PubMed
  158. In vitro assay of extracellular matrix elastin degradation.
    Chapman HA, Ehrhardt MM, Crombie G, Duffy LK| | PubMed
  159. Role of plasminogen activator in degradation of extracellular matrix protein by live human alveolar macrophages.
    Chapman HA, Reilly JJ, Kobzik L| | PubMed
  160. Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease.
    Chapman HA, Allen CL, Stone OL| | PubMed
  161. Elastinolytic activity of human cathepsin L.
    Mason RW, Johnson DA, Barrett AJ, Chapman HA| | PubMed
  162. A fibrinolytic inhibitor of human alveolar macrophages. Induction with endotoxin.
    Chapman HA, Stone OL| | PubMed
  163. Characterization of a macrophage-derived plasminogen-activator inhibitor. Similarities with placental urokinase inhibitor.
    Chapman HA, Stone OL| | PubMed
  164. Human alveolar macrophages synthesize factor VII in vitro. Possible role in interstitial lung disease.
    Chapman HA, Allen CL, Stone OL, Fair DS| | PubMed
  165. Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors.
    Chapman HA, Stone OL| | PubMed
  166. Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages.
    Chapman HA, Stone OL| | PubMed
  167. Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation.
    Chapman HA, Stone OL, Vavrin Z| | PubMed
  168. Coordinate expression of macrophage procoagulant and fibrinolytic activity in vitro and in vivo.
    Chapman HA, Vavrin Z, Hibbs JB| | PubMed
  169. Macrophage fibrinolytic activity: identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor.
    Chapman HA, Vavrin Z, Hibbs JB| | PubMed
  170. Modulation of plasminogen activator secretion by activated macrophages: influence of serum factors and correlation with tumoricidal potential.
    Chapman HA, Vavrin Z, Hibbs JB| | PubMed
  171. Characterization of the effects of endotoxin on macrophage tumor cell killing.
    Weinberg JB, Chapman HA, Hibbs JB| | PubMed
  172. Ontogeny of Peyer's patches and immunoglobulin-containing cells in pigs.
    Chapman HA, Johnson JS, Cooper MD| | PubMed