University of California San Francisco

Harold Chapman, MD

harold.chapman
Harold Chapman, MD

Professor, Medicine
School of Medicine
 

Address

513 Parnassus Avenue HSE, #201A
San Francisco, CA 94143
United States

Email: [email protected]

Education

Institution Degree Dept or School End Date
University of Utah Internal Medicine and Pulmonary Critical Care 06/80
University of Alabama Schooll of Medicine MD Medicine 06/72

Awards & Honors

Award Conferred By Date
Merit Award National Institute of Health 2001/2012
American Association of Physicians 1998
American Society for Clinical Investigation 1987

Grants and Funding

  • Program to block age-related pulmonary fibrosis and restore lung regeneration | NIH | 2026-02-15 - 2032-12-31 | Role: Principal Investigator
  • Program to promote lung regeneration and block fibrosis | NIH | 2020-02-15 - 2027-01-31 | Role: Principal Investigator
  • Phase 1 study of oral epigallocatechin-3-gallate (EGCG) in IPF patients | NIH | 2022-05-20 - 2026-04-30 | Role: Co-Principal Investigator
  • Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage | NIH | 2016-09-21 - 2024-05-31 | Role: Principal Investigator
  • Epithelial Stem/Progenitor Cells in Repair of the Injured Lung | NIH | 2015-07-15 - 2020-04-30 | Role: Principal Investigator
  • LOXL-2 dependent blockade of TGF Beta1 signaling and lung fibrosis | NIH | 2019-02-01 - 2020-01-31 | Role: Principal Investigator
  • Targeting epithelial cells to treat pulmonary fibrosis | NIH | 2012-08-09 - 2018-07-31 | Role: Co-Investigator
  • Epithelial Progenitor Cells in Lung Repair and Regeneration | NIH | 2012-01-01 - 2016-12-31 | Role: Principal Investigator
  • Epithelial Mesenchymal Transition in Pulmonary Fibrosis | NIH | 1991-01-01 - 2014-12-31 | Role: Principal Investigator
  • Urokinase Receptor Integrin Interactions in Lung Cancer | NIH | 2007-07-01 - 2013-05-31 | Role: Principal Investigator
  • Role of Elastolytic Cathepsins in Emphysema | NIH | 2001-06-01 - 2012-05-31 | Role: Principal Investigator
  • Identification, Isolation, and Reprogramming Alveolar Epithelial Progenitor Cells | NIH | 2008-12-01 - 2009-05-31 | Role: Principal Investigator
  • Cysteine Proteases in MHC Class II Antigen Presentation | NIH | 1993-01-01 - 2007-12-31 | Role: Principal Investigator
  • CATHEPSIN S AND ALZHEIMERS DISEASE | NIH | 1995-08-20 - 1998-07-31 | Role: Principal Investigator
  • INTERACTION OF HUMAN ALVEOLAR MACROPHAGES WIH FIBRIN | NIH | 1985-09-30 - 1989-03-31 | Role: Principal Investigator
  • ROLE OF HUMAN ALVEOLAR MACROPHAGES IN EMPHYSEMA | NIH | 1985-12-01 - 1988-06-30 | Role: Principal Investigator
  • ROLE OF HUMAN ALVEOLAR MACROPHAGES IN EMPHYSEMA | NIH | 1985-07-01 - 1985-08-31 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 10
  1. Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report.
    Han S, Zhou AX, Jamieson AM, Wilson AA, Zhou B, Weiss DJ, Jiang D, McKeon F, Chapman H, Miranda H, Schiller HB, Rajagopal J, Yun JH, Que J, Engelhardt JF, Basil MC, Raredon MSB, Gu M, Ghosh M, Kadur Lakshminarasimha Murthy P, Tata PR, Wang R, Davidson S, Majka SM, Tesfaigzi Y, Gomez CR, Lu Q, Ordovas-Montanes J, Kalhan R| | PubMed
  2. Alveolar Type II Cell-derived MMP1 high basal cells promote destructive microcysts in idiopathic pulmonary fibrosis.
    Garakani K, Brumwell AN, Toigo M, Jacob A, Wei Y, Ho TC, Wolters PJ, Matthay MA, Volk R, Zaro B, Iantorno S, Mitke A, Sheppard D, Auyeung V, Jourdan Le Saux C, Chapman HA| | PubMed
  3. A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis.
    Cohen ML, Brumwell AN, Ho TC, Garakani K, Montas G, Leong D, Ding VW, Golden JA, Trinh BN, Jablons DM, Matthay MA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ| | PubMed
  4. BCL-2 Modulates IRE1α Activation to Attenuate Endoplasmic Reticulum Stress and Pulmonary Fibrosis.
    Le Saux CJ, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA| | PubMed
  5. A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis.
    Cohen ML, Brumwell AN, Che Ho T, Montas G, Golden JA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ| | PubMed
  6. Human distal airways contain a multipotent secretory cell that can regenerate alveoli.
    Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE| | PubMed
  7. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
    Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T| | PubMed
  8. Nuclear IL-33 as a growth and survival agent within basal cells.
    Chapman HA| | PubMed
  9. Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity.
    Bota-Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, Tan X, Sheng K, Ahn YH, Lee S, Parra ER, Rodriguez-Canales J, Albritton J, Weiger M, Liu X, Guo HF, Yu J, Rodriguez BL, Firestone JJA, Mino B, Creighton CJ, Solis LM, Villalobos P, Raso MG, Sazer DW, Gibbons DL, Russell WK, Longmore GD, Wistuba II, Wang J, Chapman HA, Miller JS, Zong C, Kurie JM| | PubMed
  10. Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis.
    Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA| | PubMed