University of California San Francisco

carlo.condello
Carlo Condello, PhD

Associate Professor, Institute for Neurodegenerative Diseases
UCSF Weill Institute for Neurosciences

Address

675 Nelson Rising Lane, #314A
San Francisco, CA 94158
United States

Email: [email protected]
Phone: 415-502-7075

ORCID: 0000-0002-8454-5360

Awards & Honors

Award Conferred By Date
Thome Memorial Foundation; Alzheimer's Disease Drug Discovery Award UCSF 2022/2024
Sandler Foundation; Program for Breakthrough Biomedical Research, New Frontier Award UCSF 2022/2023
John A. Watson Faculty Scholar UCSF 2021/2024
Ludwig Family Foundation; Early Career Award UCSF 2021/2023

Education

Institution Degree Dept or School End Date
UCSF Postdoctoral Insitute for Neurodegenerative Diseases 2015
Yale University Postdoctoral Neurology 2012
Northwestern University Ph.D. Neuroscience 2011

Grants and Funding

  • Identification of regulatory mechanisms operating in rare pathogenic astrocyte subsets in multiple sclerosis with a novel genomic technology | NIH/NINDS | 2023-08-01 - 2028-07-31 | Role: Co-Principal Investigator
  • Structural characterization of tau aggregation variability and maturity in isolated cell types of the brain | NIH/NINDS | 2023-08-01 - 2028-07-31 | Role: Co-Principal Investigator
  • Molecular mechanisms of selective vulnerability of neurons to tauopathy | NIH/NIA | 2023-08-01 - 2028-07-31 | Role: Co-Principal Investigator
  • Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's Disease | NIH | 2018-09-30 - 2023-03-31 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 42
  1. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
    Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, Eisenberg D, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M| | PubMed
  2. Expanding the Prion Paradigm to Include Alzheimer and Parkinson Diseases.
    Condello C, Westaway D, Prusiner SB| | PubMed
  3. Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs.
    Carroll EC, Yang H, Jones JG, Oehler A, Charvat AF, Montgomery KM, Yung A, Millbern Z, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE| | PubMed
  4. Severe neurodegeneration in brains of transgenic rats producing human tau prions.
    Ayers J, Lopez TP, Steele IT, Oehler A, Roman-Albarran R, Cleveland E, Chong A, Carlson GA, Condello C, Prusiner SB| | PubMed
  5. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
    Ghosh U, Tse E, Yang H, Shi M, Caro CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C| | PubMed
  6. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold.
    Ghosh U, Tse E, Yang H, Shi M, Carlo CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C| | PubMed
  7. De novo design of peptides that bind specific conformers of α-synuclein.
    Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF| | PubMed
  8. Type-I-interferon-responsive microglia shape cortical development and behavior.
    Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK, Kaminskaya E, Nakao-Inoue H, Schwer B, Arnold TD, Molofsky AB, Condello C, Andino R, Nowakowski TJ, Molofsky AV| | PubMed
  9. De novo Design of Peptides that Bind Specific Conformers of α-Synuclein.
    Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF| | PubMed
  10. Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer's Disease.
    Kandi S, Cline EN, Rivera BM, Viola KL, Zhu J, Condello C, LeDuc RD, Klein WL, Kelleher NL, Patrie SM| | PubMed
  11. Total Chemical Synthesis of Glycosylated TREM2 Ectodomain.
    Wijegunawardena G, Castillo E, Henrickson B, Davis R, Condello C, Wu H| | PubMed
  12. Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.
    Condello C, Ayers JI, Dalgard CL, Garcia Garcia MM, Rivera BM, Seeley WW, Perl DP, Prusiner SB| | PubMed
  13. Type I interferon responsive microglia shape cortical development and behavior.
    Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Cuevas B, Vainchtein ID, Silva NJ, Xiao Y, Lidsky PV, Wang EY, Taloma SE, Nakao-Inoue H, Schwer B, Andino R, Nowakowski TJ, Molofsky AV| | PubMed
  14. EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
    Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C| | PubMed
  15. CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model.
    Johnson NR, Yuan P, Castillo E, Lopez TP, Yue W, Bond A, Rivera BM, Sullivan MC, Hirouchi M, Giles K, Aoyagi A, Condello C| | PubMed
  16. Aβ and Tau Prions Causing Alzheimer's Disease.
    Condello C, Merz GE, Aoyagi A, DeGrado WF, Prusiner SB| | PubMed
  17. Aβ and tau prions feature in the neuropathogenesis of Down syndrome.
    Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB| | PubMed
  18. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
    Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L| | PubMed
  19. Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
    Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, Prusiner SB| | PubMed
  20. Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
    Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF| | PubMed
  21. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome.
    Maxwell AM, Yuan P, Rivera BM, Schaaf W, Mladinov M, Prasher VP, Robinson AC, DeGrado WF, Condello C| | PubMed
  22. Prion biology: implications for Alzheimer's disease therapeutics.
    Condello C, DeGrado WF, Prusiner SB| | PubMed
  23. Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
    Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB| | PubMed
  24. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation.
    Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR| | PubMed
  25. Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.
    Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE| | PubMed
  26. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
    Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB| | PubMed
  27. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.
    Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB| | PubMed
  28. A novel vector for transgenesis in the rat CNS.
    Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB| | PubMed
  29. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.
    Condello C, Yuan P, Grutzendler J| | PubMed
  30. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.
    Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF| | PubMed
  31. Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease.
    Condello C, Stöehr J| | PubMed
  32. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
    Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J| | PubMed
  33. Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.
    Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB| | PubMed
  34. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
    Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J| | PubMed
  35. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
    Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB| | PubMed
  36. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
    Condello C, Yuan P, Schain A, Grutzendler J| | PubMed
  37. Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.
    Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB| | PubMed
  38. Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.
    Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB| | PubMed
  39. Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures.
    Abraham J, Fox PD, Condello C, Bartolini A, Koh S| | PubMed
  40. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition.
    Condello C, Schain A, Grutzendler J| | PubMed
  41. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis.
    Liu Z, Condello C, Schain A, Harb R, Grutzendler J| | PubMed
  42. Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration.
    Kalkonde YV, Morgan WW, Sigala J, Maffi SK, Condello C, Kuziel W, Ahuja SS, Ahuja SK| | PubMed