University of California San Francisco

Bruce Conklin, MD

Bruce Conklin, MD
Bruce Conklin, MD

Professor, Medicine
School of Medicine

Address

35 Medical Center Way, #903E
San Francisco, CA 94143
United States

Email: [email protected]

ORCID: 0000-0003-1463-6061

Education

Institution Degree Dept or School End Date
University of California San Francisco Molecular Pharmacology 01/1995
Johns Hopkins Hospital Internal Medicine 06/1990
Case Western Reserve School of Medicine M.D. Medicine 06/1988
University of California, Berkeley, CA A.B. Public Health 06/1982

Awards & Honors

Award Conferred By Date
CWRU School of Medicine Distinguished Alumni Award 2016
Fellow, California Academy of Sciences 2011
Scientific American 50 Award 2008
American Society for Clinical Investigation 2003
Medical Resident Research Award-NIDDK 1990

Grants and Funding

  • C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches | NIH | 2021-05-01 - 2024-04-30 | Role: Principal Investigator
  • Therapeutic genome editing to treat Best disease | NIH | 2017-09-30 - 2022-06-30 | Role: Principal Investigator
  • Protein quality control, cardiomyopathy, cardiotoxicity and human isogenic iPSCs | NIH | 2017-07-15 - 2021-06-30 | Role: Principal Investigator
  • Identifying Therapeutic Targets for RNA Splicing-Related Cardiomyopathy | NIH | 2015-12-14 - 2019-11-30 | Role: Principal Investigator
  • Transcriptional Networks During Cardiac Differentiation | NIH | 2007-07-01 - 2018-07-31 | Role: Co-Investigator
  • Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart Diseas | NIH | 2009-09-30 - 2016-10-31 | Role: Co-Principal Investigator
  • Structures of Protein Complexes Regulating Transcription in Enbryonic Stem Cells | NIH | 2010-09-30 - 2016-06-30 | Role: Co-Investigator
  • The Epigenetic Landscape of Heart Development | NIH | 2009-09-30 - 2015-08-31 | Role: Co-Principal Investigator
  • Disease Specific Cardiac Tissue Models | NIH | 2011-09-05 - 2015-05-31 | Role: Co-Principal Investigator
  • Tissue Engineering with a Modular RASSL Toolbox | NIH | 1998-07-01 - 2013-06-30 | Role: Principal Investigator
  • GenMAPP-CS, a dynamic resource pathway analysis | NIH | 2004-08-18 - 2012-07-31 | Role: Principal Investigator
  • Induced pluripotent stem cells in the understanding and treatment of heart diseas | NIH | 2008-12-01 - 2009-05-31 | Role: Co-Principal Investigator
  • GenMAPP: A tool for pathway analysis of genomic data | NIH | 2004-08-18 - 2007-10-31 | Role: Principal Investigator
  • COLLABORATIVE R01--ROLES OF G PROTEINS IN CARDIOMYOPATHY | NIH | 1998-09-30 - 2003-08-31 | Role: Principal Investigator
  • MUTANT G PROTEINS REVEAL SIGNALING PATHWAYS | NIH | 1991-01-01 - 1995-12-31 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 191
  1. Leveraging human genetic variation to therapeutically target hundreds of genes with dominant & dispensable disease alleles.
    Ramey GD, Cowan QT, Saxena AG, Macklin BL, Watry HL, Mei X, Dierks P, Judge LM, Conklin BR, Capra JA| | PubMed
  2. Using image classifiers to predict CMT2A disease-relevant mitochondrial motility phenotypes in iPSC motor neurons.
    Epstein L, Weiner AC, Macklin BL, Kelly KR, Conklin BR, Engelhardt BE| | PubMed
  3. Monitoring biological effects of somatic cell genome editing.
    Freedman BS, Bulte JWM, Conklin BR, Judge LM, Dwinell MR, Geurts AM, Sitton MJ, Mahajan V, Kiani S, Gersbach CA, Ebrahimkhani MR, Kelly JJ, Ronald JA, Morizane R, Gupta N, Shakeri-Zadeh A, Vo N, Saha K, Saxena S, Gamm DM, Sinha D, Tarantal AF, Vandsburger M, Matsubara A, Fu H, Tsai SQ, SCGE Dissemination and Coordinating Center Toolkit Team, SCGE Biological Effects Initiative| | PubMed
  4. Generation of WTD, a control human iPSC line for genetic research.
    Macklin BL, Runyon WV, Feliciano CM, Dierks PH, Kelly KR, Watry HL, Judge LM, Conklin BR| | PubMed
  5. Haplotype editing with CRISPR-Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL.
    Dua PH, Simon BMJ, Marley CBE, Feliciano CM, Watry HL, Cowan QT, Steury D, Abraham A, Gilbertson EN, Ramey GD, Capra JA, Conklin BR, Judge LM| | PubMed
  6. Characterizing and controlling CRISPR repair outcomes in nondividing human cells.
    Ramadoss GN, Namaganda SJ, Kumar MM, Hamilton JR, Sharma R, Chow KG, Workley LA, Macklin BL, Sun M, Ha AS, Liu JC, Fellmann C, Watry HL, Dierks PH, Bose RS, Jin J, Perez BS, Sandoval Espinoza CR, Matia MP, Lu SH, Judge LM, Shy BR, Nussenzweig A, Adamson B, Murthy N, Doudna JA, Kampmann M, Conklin BR| | PubMed
  7. Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins.
    Xu D, Besselink S, Ramadoss GN, Dierks PH, Lubin JP, Pattali RK, Brim JI, Christenson AE, Colias PJ, Ornelas IJ, Nguyen CD, Chasins SE, Conklin BR, Nuñez JK| | PubMed
  8. Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with BAG3 P209L myofibrillar myopathy-6.
    Filippi K, RiĂŸe I, Judge LM, Conklin BR, Fleischmann BK, Hesse M| | PubMed
  9. Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes.
    Ramadoss GN, Namaganda SJ, Hamilton JR, Sharma R, Chow KG, Macklin BL, Sun M, Liu JC, Fellmann C, Watry HL, Jin J, Perez BS, Espinoza CRS, Matia MP, Lu SH, Judge LM, Nussenzweig A, Adamson B, Murthy N, Doudna JA, Kampmann M, Conklin BR| | PubMed
  10. Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells.
    Chu SN, Soupene E, Sharma D, Sinha R, McCreary T, Hernandez B, Shen H, Wienert B, Bowman C, Yin H, Lesch BJ, Jia K, Romero KA, Kostamo Z, Zhang Y, Tran T, Cordero M, Homma S, Hampton JP, Gardner JM, Conklin BR, MacKenzie TC, Sheehan VA, Porteus MH, Cromer MK| | PubMed
  11. Haplotype editing with CRISPR/Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL.
    Dua PH, Simon BMJ, Marley CBE, Feliciano CM, Watry HL, Steury D, Abraham A, Gilbertson EN, Ramey GD, Capra JA, Conklin BR, Judge LM| | PubMed
  12. Generation and characterization of an isogenic control line by correcting the BAG3 P209L mutation of a human induced pluripotent stem cell (hiPSC) line from a patient with myofibrillar myopathy-6.
    Filippi K, RiĂŸe I, Judge LM, Conklin BR, Fleischmann BK, Hesse M| | PubMed
  13. Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.
    Aradhana Sachdev, Kamaljot Gil, Maria Sckaff, Alisha M Birk, Olubankole Aladesuyi Arogundade, Katherine A Brown, Runvir S Chouhan, Patrick Issagholian Lewin, Esha Patel, Kathleen Keough, Bruce Conklin, Alec ST Smith, Claire Clelland| | UCSF Research Profile
  14. Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins.
    Xu D, Besselink S, Ramadoss GN, Dierks PH, Lubin JP, Pattali RK, Brim JI, Christenson AE, Colias PJ, Ornelas IJ, Nguyen CD, Chasins SE, Conklin BR, Nuñez JK| | PubMed
  15. Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution.
    Yeh LH, Ivanov IE, Chandler T, Byrum JR, Chhun BB, Guo SM, Foltz C, Hashemi E, Perez-Bermejo JA, Wang H, Yu Y, Kazansky PG, Conklin BR, Han MH, Mehta SB| | PubMed
  16. Advances and challenges in modeling inherited peripheral neuropathies using iPSCs.
    Van Lent J, Prior R, PĂ©rez Siles G, Cutrupi AN, Kennerson ML, Vangansewinkel T, Wolfs E, Mukherjee-Clavin B, Nevin Z, Judge L, Conklin B, Tyynismaa H, Clark AJ, Bennett DL, Van Den Bosch L, Saporta M, Timmerman V| | PubMed
  17. Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells.
    Chu SN, Soupene E, Wienert B, Yin H, Sharma D, McCreary T, Jia K, Homma S, Hampton JP, Gardner JM, Conklin BR, MacKenzie TC, Porteus MH, Cromer MK| | PubMed
  18. Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.
    Sachdev A, Gill K, Sckaff M, Birk AM, Aladesuyi Arogundade O, Brown KA, Chouhan RS, Issagholian-Lewin PO, Patel E, Watry HL, Bernardi MT, Keough KC, Tsai YC, Smith AST, Conklin BR, Clelland CD| | PubMed
  19. Give heart cells a beat: An interactive museum exhibit that synchronizes stem cell-derived cardiomyocytes to visitors' heartbeat.
    Perez-Bermejo JA, Reisman SJ, Ma J, Carrison-Stone D, Cerrito C, Ribeiro AJS, Conklin BR, Yu K| | PubMed
  20. Validated assays for the quantification of C9orf72 human pathology.
    Salomonsson SE, Maltos AM, Gill K, Aladesuyi Arogundade O, Brown KA, Sachdev A, Sckaff M, Lam KJK, Fisher IJ, Chouhan RS, Van Laar VS, Marley CB, McLaughlin I, Bankiewicz KS, Tsai YC, Conklin BR, Clelland CD| | PubMed
  21. Dual a-Globin and Truncated EPO Receptor Knockin Restores Hemoglobin Production in a-Thalassemia-Derived Hematopoietic Stem and Progenitor Cells.
    Simon N Chu, Eric Soupene, Beeke Wienert, Han Yin, Devesh Sharma, Kun Jia, Shota Homma, Jessica P Hampton, Bruce Conklin, Tippi C. MacKenzie, Matthew Porteus, Kyle Cromer| | UCSF Research Profile
  22. Functional analysis of a common BAG3 allele associated with protection from heart failure.
    Perez-Bermejo JA, Judge LM, Jensen CL, Wu K, Watry HL, Truong A, Ho JJ, Carter M, Runyon WV, Kaake RM, Pulido EH, Mandegar MA, Swaney DL, So PL, Krogan NJ, Conklin BR| | PubMed
  23. Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia using human induced pluripotent stem cell-derived RPE.
    Iwagawa T, Masumoto H, Tabuchi H, Tani K, Conklin BR, Watanabe S| | PubMed
  24. A reference human induced pluripotent stem cell line for large-scale collaborative studies.
    Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Ă–ttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, SchĂ¼le B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT| | PubMed
  25. Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.
    Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, HĂ¼ttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D| | PubMed
  26. Transcription factor protein interactomes reveal genetic determinants in heart disease.
    Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, HĂ¼ttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D| | PubMed
  27. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
    Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M| | PubMed
  28. Abstract 11332: Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes.
    Barbara Gonzalez Teran, Maureen Pittman, Reuben Thomas, Franco Felix, Desmond Richmond-Buccola, Krishna Choudhary, Elisabetta Moroni, Colombo Giorgio, Arun Padmanabhan, Mauro Costa, Yu Huang, Michael Alexanian, Clara Lee, Bonie Cole, Kaitlen Samse-Knapp, Michael McGregor, Casey Gifford, Ruth Huttenhain, Bruce Gelb, Bruce Conklin, Brian L Black, Benoit Bruneau, Nevan Krogan, Katherine Pollard, Deepak Srivastava| | UCSF Research Profile
  29. Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies.
    Fenix AM, Miyaoka Y, Bertero A, Blue SM, Spindler MJ, Tan KKB, Perez-Bermejo JA, Chan AH, Mayerl SJ, Nguyen TD, Russell CR, Lizarraga PP, Truong A, So PL, Kulkarni A, Chetal K, Sathe S, Sniadecki NJ, Yeo GW, Murry CE, Conklin BR, Salomonis N| | PubMed
  30. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
    Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M| | PubMed
  31. Allele-Specific Gene Editing Rescues Pathology in a Human Model of Charcot-Marie-Tooth Disease Type 2E.
    Feliciano CM, Wu K, Watry HL, Marley CBE, Ramadoss GN, Ghanim HY, Liu AZ, Zholudeva LV, McDevitt TC, Saporta MA, Conklin BR, Judge LM| | PubMed
  32. Bioengineered optogenetic model of human neuromuscular junction.
    Vila OF, Chavez M, Ma SP, Yeager K, Zholudeva LV, ColĂ³n-Mercado JM, Qu Y, Nash TR, Lai C, Feliciano CM, Carter M, Kamm RD, Judge LM, Conklin BR, Ward ME, McDevitt TC, Vunjak-Novakovic G| | PubMed
  33. Transcription factor overexpression drives reliable differentiation of retinal pigment epithelium from human induced pluripotent stem cells.
    Dewell TE, Gjoni K, Liu AZ, Libby ARG, Moore AT, So PL, Conklin BR| | PubMed
  34. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.
    Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC| | PubMed
  35. Investigating Zeta Globin Gene Expression to Develop a Potential Therapy for Alpha Thalassemia Major.
    Georgia L. Gregory, Beeke Wienert, Marisa Schwab, Billie Rachael Lianoglou, Roger P. Hollis, Donald B. Kohn, Bruce R. Conklin, Tippi C. MacKenzie| | UCSF Research Profile
  36. SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.
    PĂ©rez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC| | PubMed
  37. Rapid, precise quantification of large DNA excisions and inversions by ddPCR.
    Watry HL, Feliciano CM, Gjoni K, Takahashi G, Miyaoka Y, Conklin BR, Judge LM| | PubMed
  38. Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.
    Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, Perli SD, Conklin BR, Yamanaka S| | PubMed
  39. Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair.
    Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, Shin J, Kazane KR, Gregory GL, Carter MAM, Wright F, Conklin BR, Marson A, Richardson CD, Corn JE| | PubMed
  40. CRISPR off-target detection with DISCOVER-seq.
    Wienert B, Wyman SK, Yeh CD, Conklin BR, Corn JE| | PubMed
  41. Cardiac Microtissues: Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity (Adv. Healthcare Mater. 8/2020).
    Chenyan Wang, Sangmo Koo, Minok Park, Zacharias Vangelatos, Plansky Hoang, Bruce R. Conklin, Costas P. Grigoropoulos, Kevin E. Healy, Zhen Ma| | UCSF Research Profile
  42. Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity.
    Wang C, Koo S, Park M, Vangelatos Z, Hoang P, Conklin BR, Grigoropoulos CP, Healy KE, Ma Z| | PubMed
  43. Automated Design of Pluripotent Stem Cell Self-Organization.
    Libby ARG, Briers D, Haghighi I, Joy DA, Conklin BR, Belta C, McDevitt TC| | PubMed
  44. AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design.
    Keough KC, Lyalina S, Olvera MP, Whalen S, Conklin BR, Pollard KS| | PubMed
  45. Abstract 934: Physical and Genetic Interaction Analyses in Human Pluripotent Stem Cell-Derived Cardiomyocytes to Study Protein Quality Control Disease in the Heart.
    Juan A Perez-Bermejo, Luke M Judge, Kenneth Wu, Christina L Jensen, Robyn M Kaake, Danielle Swaney, Po-Lin So, Nevan J Krogan, Bruce R Conklin| | UCSF Research Profile
  46. Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells.
    Yoshinaga D, Baba S, Makiyama T, Shibata H, Hirata T, Akagi K, Matsuda K, Kohjitani H, Wuriyanghai Y, Umeda K, Yamamoto Y, Conklin BR, Horie M, Takita J, Heike T| | PubMed
  47. Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
    Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y| | PubMed
  48. A NOVEL ROLE FOR THE FTD-CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING.
    Claire Clelland, J. Iker Etchegaray, Lay Kodama, Faten Sayed, Aradhana Sachdev, Yaqiao Li, David Le, Lihong Zhan, Yungui Zhou, Duc Duong, Nicholas T. Seyfried, Thomas G. Kukar, Li Xuan Tan, Aparna Lakkaraju, Bruce Conklin, Li Gan| | UCSF Research Profile
  49. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.
    Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE| | PubMed
  50. On the road to a gene drive in mammals.
    Conklin BR| | PubMed
  51. MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification.
    Eskildsen TV, Ayoubi S, Thomassen M, Burton M, Mandegar MA, Conklin BR, Jensen CH, Andersen DC, Sheikh SP| | PubMed
  52. Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.
    Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC| | PubMed
  53. Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.
    Ma Z, Huebsch N, Koo S, Mandegar MA, Siemons B, Boggess S, Conklin BR, Grigoropoulos CP, Healy KE| | PubMed
  54. Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes.
    Hoang P, Huebsch N, Bang SH, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S| | PubMed
  55. Quantitatively Characterizing Drug-Induced Arrhythmic Contractile Motions of Human Stem Cell-Derived Cardiomyocytes.
    Plansky Hoang, Nathaniel Huebsch, Shin Hyuk Bang, Brian A. Siemons, Bruce R. Conklin, Kevin E. Healy, Zhen Ma, Sabir Jacquir| | UCSF Research Profile
  56. Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells.
    Hoang P, Wang J, Conklin BR, Healy KE, Ma Z| | PubMed
  57. Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR.
    Miyaoka Y, Mayerl SJ, Chan AH, Conklin BR| | PubMed
  58. TMOD-09. HUMAN PLURIPOTENT STEM CELL-BASED MODELS OF NEUROBLASTOMA.
    Miller Huang, Tina Zheng, Jeffrey Guo, Colin Sperring, Matthew Miller, Lauren McHenry, Qiqi Zhen, Branden Moriarity, Marianne Bronner, Bruce Conklin, David Largaespada, John Maris, Katherine Matthay, William Weiss| | UCSF Research Profile
  59. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.
    Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR| | PubMed
  60. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.
    Ribeiro AJS, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL| | PubMed
  61. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.
    Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA| | PubMed
  62. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.
    Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM| | PubMed
  63. GENT-49. SYSTEMATIC IDENTIFICATION OF ESSENTIAL LONG NON-CODING RNA GENES IN GLIOBLASTOMA.
    Siyuan Liu, Max Horlbeck, Seung Woo Cho, Harjus Birk, Martina Malatesta, Daniel He, Jacqueline Villalta, Min Cho, Yuwen Chen, Mohammad Mandegar, Michael Olvera, Bruce Conklin, Howard Chang, Jonathan Weissman, Daniel Lim| | UCSF Research Profile
  64. BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
    Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S| | PubMed
  65. Organs-on-a-chip – Microphysiological platforms as in vitro models of cardiac and adipose tissue.
    P. Loskill, A. Mathur, B.R. Conklin, A. Stahl, L.P. Lee, K.E. Healy| | UCSF Research Profile
  66. Detecting Single-Nucleotide Substitutions Induced by Genome Editing.
    Miyaoka Y, Chan AH, Conklin BR| | PubMed
  67. Using Digital Polymerase Chain Reaction to Detect Single-Nucleotide Substitutions Induced by Genome Editing.
    Miyaoka Y, Chan AH, Conklin BR| | PubMed
  68. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.
    Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA| | PubMed
  69. Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.
    Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR| | PubMed
  70. Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing.
    Miyaoka Y, Berman JR, Cooper SB, Mayerl SJ, Chan AH, Zhang B, Karlin-Neumann GA, Conklin BR| | PubMed
  71. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.
    Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR| | PubMed
  72. Generating trunk neural crest from human pluripotent stem cells.
    Huang M, Miller ML, McHenry LK, Zheng T, Zhen Q, Ilkhanizadeh S, Conklin BR, Bronner ME, Weiss WA| | PubMed
  73. Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.
    Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA| | PubMed
  74. Abstract 3230: Human stem cell-based model of MYCN-driven neuroblastoma.
    Miller Huang, Lauren K. McHenry, Matthew L. Miller, Grace E. Kim, Branden S. Moriarity, Yuichiro Miyaoka, Marianne E. Bronner, David A. Largaespada, Bruce R. Conklin, Hanlee P. Ji, John M. Maris, Katherine K. Matthay, William A. Weiss| | UCSF Research Profile
  75. Self-organizing human cardiac microchambers mediated by geometric confinement.
    Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE| | PubMed
  76. Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome.
    Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ| | PubMed
  77. Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.
    Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA| | PubMed
  78. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
    Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ| | PubMed
  79. A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing.
    Maddah M, Heidmann JD, Mandegar MA, Walker CD, Bolouki S, Conklin BR, Loewke KE| | PubMed
  80. Human iPSC-based cardiac microphysiological system for drug screening applications.
    Mathur A, Loskill P, Shao K, Huebsch N, Hong S, Marcus SG, Marks N, Mandegar M, Conklin BR, Lee LP, Healy KE| | PubMed
  81. Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.
    Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA| | PubMed
  82. Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.
    Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS| | PubMed
  83. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
    Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L| | PubMed
  84. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.
    Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur A, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka AC, Russell CR, So PL, Conklin BR, Healy KE| | PubMed
  85. Classifying the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes using Voltage Sensitive Dyes and Supervised Machine Learning.
    Christopher M. Heylman, Rupsa Datta, Bruce R. Conklin, Steven C. George, Enrico Gratton| | UCSF Research Profile
  86. Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.
    Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR| | PubMed
  87. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.
    Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA| | PubMed
  88. Isolation of single-base genome-edited human iPS cells without antibiotic selection.
    Miyaoka Y, Chan AH, Judge LM, Yoo J, Huang M, Nguyen TD, Lizarraga PP, So PL, Conklin BR| | PubMed
  89. Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development.
    Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE| | PubMed
  90. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
    Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC| | PubMed
  91. Three-dimensional filamentous human diseased cardiac tissue model.
    Ma Z, Koo S, Finnegan MA, Loskill P, Huebsch N, Marks NC, Conklin BR, Grigoropoulos CP, Healy KE| | PubMed
  92. The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
    Taglieri DM, Johnson KR, Burmeister BT, Monasky MM, Spindler MJ, DeSantiago J, Banach K, Conklin BR, Carnegie GK| | PubMed
  93. Sculpting genomes with a hammer and chisel.
    Conklin BR| | PubMed
  94. A robust method to derive functional neural crest cells from human pluripotent stem cells.
    Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR| | PubMed
  95. AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.
    Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR| | PubMed
  96. Structure of a novel winged-helix like domain from human NFRKB protein.
    Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA| | PubMed
  97. Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.
    Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S| | PubMed
  98. GO-Elite: a flexible solution for pathway and ontology over-representation.
    Zambon AC, Gaj S, Ho I, Hanspers K, Vranizan K, Evelo CT, Conklin BR, Pico AR, Salomonis N| | PubMed
  99. WikiPathways: building research communities on biological pathways.
    Kelder T, van Iersel MP, Hanspers K, Kutmon M, Conklin BR, Evelo CT, Pico AR| | PubMed
  100. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.
    Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K| | PubMed
  101. Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor.
    Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC| | PubMed
  102. Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.
    Millard SM, Louie AM, Wattanachanya L, Wronski TJ, Conklin BR, Nissenson RA| | PubMed
  103. Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.
    Hsiao EC, Nguyen TD, Ng JK, Scott MJ, Chang WC, Zahed H, Conklin BR| | PubMed
  104. Finding the right questions: exploratory pathway analysis to enhance biological discovery in large datasets.
    Kelder T, Conklin BR, Evelo CT, Pico AR| | PubMed
  105. Stem cell pluripotency: alternative modes of transcription regulation.
    Salomonis N, Conklin BR| | PubMed
  106. Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance.
    van Laake LW, Qian L, Cheng P, Huang Y, Hsiao EC, Conklin BR, Srivastava D| | PubMed
  107. AltAnalyze and DomainGraph: analyzing and visualizing exon expression data.
    Emig D, Salomonis N, Baumbach J, Lengauer T, Conklin BR, Albrecht M| | PubMed
  108. Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation.
    Salomonis N, Schlieve CR, Pereira L, Wahlquist C, Colas A, Zambon AC, Vranizan K, Spindler MJ, Pico AR, Cline MS, Clark TA, Williams A, Blume JE, Samal E, Mercola M, Merrill BJ, Conklin BR| | PubMed
  109. Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.
    Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR| | PubMed
  110. Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation.
    Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA| | PubMed
  111. Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning.
    Lo B, Parham L, Alvarez-Buylla A, Cedars M, Conklin B, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Wagner R| | PubMed
  112. The BridgeDb framework: standardized access to gene, protein and metabolite identifier mapping services.
    van Iersel MP, Pico AR, Kelder T, Gao J, Ho I, Hanspers K, Conklin BR, Evelo CT| | PubMed
  113. G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies.
    Nakamura K, Salomonis N, Tomoda K, Yamanaka S, Conklin BR| | PubMed
  114. Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors.
    Salomonis N, Nelson B, Vranizan K, Pico AR, Hanspers K, Kuchinsky A, Ta L, Mercola M, Conklin BR| | PubMed
  115. Consent: criteria should be drawn up for tissue donors.
    Lo B, Conklin BR| | PubMed
  116. Journal club. A geneticist wonders why we need to sleep.
    Conklin BR| | PubMed
  117. Mining biological pathways using WikiPathways web services.
    Kelder T, Pico AR, Hanspers K, van Iersel MP, Evelo C, Conklin BR| | PubMed
  118. AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans.
    Neumann SA, Tingley WG, Conklin BR, Shrader CJ, Peet E, Muldoon MF, Jennings JR, Ferrell RE, Manuck SB| | PubMed
  119. Endogenous Gi signaling in osteoblasts participates in sexually dimorphic regulation of cancellous bone structure.
    S. Millard, A. Louie, C. Manalac, W. Lu, N. Cotte, T.J. Wronski, B. Conklin, R.A. Nissenson| | UCSF Research Profile
  120. Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes.
    Kita-Matsuo H, Barcova M, Prigozhina N, Salomonis N, Wei K, Jacot JG, Nelson B, Spiering S, Haverslag R, Kim C, Talantova M, Bajpai R, Calzolari D, Terskikh A, McCulloch AD, Price JH, Conklin BR, Chen HS, Mercola M| | PubMed
  121. Obtaining consent for future research with induced pluripotent cells: opportunities and challenges.
    Aalto-Setälä K, Conklin BR, Lo B| | PubMed
  122. SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system.
    Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M| | PubMed
  123. Presenting and exploring biological pathways with PathVisio.
    van Iersel MP, Kelder T, Pico AR, Hanspers K, Coort S, Conklin BR, Evelo C| | PubMed
  124. Engineering GPCR signaling pathways with RASSLs.
    Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL| | PubMed
  125. WikiPathways: pathway editing for the people.
    Pico AR, Kelder T, van Iersel MP, Hanspers K, Conklin BR, Evelo C| | PubMed
  126. Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter.
    Hsiao EC, Yoshinaga Y, Nguyen TD, Musone SL, Kim JE, Swinton P, Espineda I, Manalac C, deJong PJ, Conklin BR| | PubMed
  127. An Introduction to Pathway Analysis with GenMAPP.
    Kristina Hanspers, Alexander R. Pico, Nathan Salomonis, Alexander C. Zambon, Karen Vranizan, Steven C. Lawlor, Kam D. Dahlquist, Scott W. Doniger, Bruce R. Conklin| | UCSF Research Profile
  128. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.
    Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D| | PubMed
  129. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells identifies genes and pathways of cAMP/PKA-promoted apoptosis.
    Lingzhi Zhang, Alexander C Zambon, Karen Vranizan, Kanishka Pothula, Bruce R Conklin, Paul A Insel| | UCSF Research Profile
  130. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.
    Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA| | PubMed
  131. Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor.
    Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao EC, Conklin BR| | PubMed
  132. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.
    Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA| | PubMed
  133. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells.
    Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA| | PubMed
  134. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.
    Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR| | PubMed
  135. Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.
    Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR| | PubMed
  136. GenMAPP 2: new features and resources for pathway analysis.
    Salomonis N, Hanspers K, Zambon AC, Vranizan K, Lawlor SC, Dahlquist KD, Doniger SW, Stuart J, Conklin BR, Pico AR| | PubMed
  137. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
    Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D| | PubMed
  138. Interfacing silicon nanowires with mammalian cells.
    Kim W, Ng JK, Kunitake ME, Conklin BR, Yang P| | PubMed
  139. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.
    Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR| | PubMed
  140. New tools to build synthetic hormonal pathways.
    Conklin BR| | PubMed
  141. Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes.
    Sweger EJ, Casper KB, Scearce-Levie K, Conklin BR, McCarthy KD| | PubMed
  142. Integration of biological networks and gene expression data using Cytoscape.
    Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T, Bader GD| | PubMed
  143. mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses.
    Nicholls RE, Zhang XL, Bailey CP, Conklin BR, Kandel ER, Stanton PK| | PubMed
  144. A Series of RASSLs Activated by a Single Agonist.
    Peter Chang, Edward Hsiao, Alex C Zambon, Bruce R Conklin| | UCSF Research Profile
  145. The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.
    Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE| | PubMed
  146. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator.
    Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ| | PubMed
  147. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A.
    Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA| | PubMed
  148. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression.
    McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ| | PubMed
  149. Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling.
    Scearce-Levie K, Lieberman MD, Elliott HH, Conklin BR| | PubMed
  150. Identifying genetic networks underlying myometrial transition to labor.
    Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR| | PubMed
  151. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.
    Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C| | PubMed
  152. A public gene trap resource for mouse functional genomics.
    Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J, International Gene Trap Consortium| | PubMed
  153. Time- and exercise-dependent gene regulation in human skeletal muscle.
    Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, Takahashi JS, Schambelan M, Conklin BR| | PubMed
  154. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo.
    Srinivasan S, Vaisse C, Conklin BR| | PubMed
  155. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data.
    Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR| | PubMed
  156. Regression approaches for microarray data analysis.
    Segal MR, Dahlquist KD, Conklin BR| | PubMed
  157. GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways.
    Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR| | PubMed
  158. Tools for dissecting signaling pathways in vivo: receptors activated solely by synthetic ligands.
    Scearce-Levie K, Coward P, Redfern CH, Conklin BR| | PubMed
  159. Engineering receptors activated solely by synthetic ligands (RASSLs).
    Scearce-Levie K, Coward P, Redfern CH, Conklin BR| | PubMed
  160. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy.
    Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR| | PubMed
  161. Evaluation of thrombolysis in a porcine model of chronic deep venous thrombosis: an endovascular model.
    Lin PH, Chen C, Surowiec SM, Conklin B, Bush RL, Lumsden AB| | PubMed
  162. Tetracycline-inducible system for photoreceptor-specific gene expression.
    Chang MA, Horner JW, Conklin BR, DePinho RA, Bok D, Zack DJ| | PubMed
  163. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.
    Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, Baker AJ, Conklin BR| | PubMed
  164. Chemically modified oligonucleotides exhibit decreased immune stimulation in mice.
    Henry S, Stecker K, Brooks D, Monteith D, Conklin B, Bennett CF| | PubMed
  165. A critical period of vulnerability to hyperactive Gq signaling revealed by inducible and heart-specific expression of Gq* in transgenic mice.
    Nathalie Cotte, Charles H. Redfern, Peter Mikus, Nathan Salomonis, Michael Y. Degtyarev, Peter S. Coward, Andrew Kwa, Tetsuo Shioi, Nila Shah, Tim McKinsey, Eric Olson, Seigo Izumo, Janet Warrington, Anthony J. Baker, Bruce R. Conklin| | UCSF Research Profile
  166. Genomic analysis of an inducible and reversible model of dilated cardiomyopathy.
    Charles H. Redfern, Michael Y. Degtyarev, Kavin Desai, Andrew Kwa, Glenn I. Fishman, Daniel Bernstein, Anthony J. Baker, Bruce R. Conklin| | UCSF Research Profile
  167. Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors.
    Coward P, Chan SD, Wada HG, Humphries GM, Conklin BR| | PubMed
  168. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice.
    Redfern CH, Coward P, Degtyarev MY, Lee EK, Kwa AT, Hennighausen L, Bujard H, Fishman GI, Conklin BR| | PubMed
  169. Controlling signaling with a specifically designed Gi-coupled receptor.
    Coward P, Wada HG, Falk MS, Chan SD, Meng F, Akil H, Conklin BR| | PubMed
  170. The N-terminal extension of Galphaq is critical for constraining the selectivity of receptor coupling.
    Kostenis E, Degtyarev MY, Conklin BR, Wess J| | PubMed
  171. Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits.
    Kostenis E, Conklin BR, Wess J| | PubMed
  172. Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals.
    Burstein ES, Bräuner-Osborne H, Spalding TA, Conklin BR, Brann MR| | PubMed
  173. Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation.
    Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR| | PubMed
  174. Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis.
    Liu J, Blin N, Conklin BR, Wess J| | PubMed
  175. Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation.
    Liu J, Conklin BR, Blin N, Yun J, Wess J| | PubMed
  176. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system.
    Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE| | PubMed
  177. G alpha 13 stimulates Na-H exchange.
    Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL| | PubMed
  178. Homeostatic signals. Marriage of the flytrap and the serpent.
    Conklin BR, Bourne HR| | PubMed
  179. Mouse coat colour reconsidered.
    Conklin BR, Bourne HR| | PubMed
  180. Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq.
    Lustig KD, Conklin BR, Herzmark P, Taussig R, Bourne HR| | PubMed
  181. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.
    Conklin BR, Bourne HR| | PubMed
  182. Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha.
    Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR| | PubMed
  183. A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways.
    Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR| | PubMed
  184. Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits.
    Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR| | PubMed
  185. Gz-mediated hormonal inhibition of cyclic AMP accumulation.
    Wong YH, Conklin BR, Bourne HR| | PubMed
  186. Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.
    Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR| | PubMed
  187. Detection of coincident signals by G proteins and adenylyl cyclase.
    Bourne HR, Lustig KD, Wong YH, Conklin BR| | PubMed
  188. Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor.
    Felder CC, Ma AL, Conklin BR| | PubMed
  189. Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.
    Conklin BR, Brann MR, Buckley NJ, Ma AL, Bonner TI, Axelrod J| | PubMed
  190. Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts.
    Conklin BR, Burch RM, Steranka LR, Axelrod J| | PubMed
  191. Self-care capacity and anticholinergic drug levels in nursing home patients.
    Rovner BW, David A, Lucas-Blaustein MJ, Conklin B, Filipp L, Tune L| | PubMed