University of California San Francisco

arun.prakashbudde
Arun Prakash Budde, MD, PhD

Professor, Anesthesia
School of Medicine

Education

Institution Degree Dept or School End Date
University of California San Francisco Post-doctoral Fellowship/Clinical Instructor 07/2011
University of California San Francisco Anesthesiology 07/2009
Santa Clara Valley Medical Center Internship in Internal Medicine 06/2006
New York University School of Medicine MD/PhD Medicine/Immunology 06/2005
University of Rochester Bachelors of Science/Arts Chemistry/History 06/1996

Awards & Honors

Award Conferred By Date
Laboratory Safety Award UCSF 2019

Collaboration Interests

I am interested in:

  • physician scientist

Grants and Funding

  • The Gut-Lung Axis: Immunometabolism Linking the Gut Microbiome and Lung Imunity | NIH | 2020-02-15 - 2025-01-31 | Role: Principal Investigator
  • Role of Innate Immune Cells and Pathways in Ventilated Lung Ischemia Reperfusion | NIH | 2015-02-01 - 2020-01-31 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 25
  1. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice.
    Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J| | PubMed
  2. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.
    Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J| | PubMed
  3. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
    Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS| | PubMed
  4. Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles.
    Zhang N, Francis KP, Prakash A, Ansaldi D| | PubMed
  5. Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice.
    Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J| | PubMed
  6. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response.
    Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J| | PubMed
  7. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo.
    Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J| | PubMed
  8. Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge.
    Prakash A, Hellman J| | PubMed
  9. Regulation of IRF7 through cell type-specific protein stability.
    Prakash A, Levy DE| | PubMed
  10. Tissue-specific positive feedback requirements for production of type I interferon following virus infection.
    Prakash A, Smith E, Lee CK, Levy DE| | PubMed
25
View all 25 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 25
  1. Sequential Blood Collection from Inferior Vena Cava Followed by Portal Vein to Evaluate Gut Microbial Metabolites in Mice
    Doan, T. N. M., Maruyama, D., Tian, X., Prakash, A| | UCSF Research Profile
  2. Regulation of Lung Immune Tone by the Gut-Lung Axis via Dietary Fiber, Gut Microbiota, and Short-Chain Fatty Acids
    Maruyama D, Liao WI, Tian X, Bredon M, Knapp J, Tat C, Doan TNM, Chassaing B, Bhargava A, Sokol H, Prakash A.| | UCSF Research Profile
  3. A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery
    Liao, W. I., Maruyama, D., Kianian, F., Tat, C., Tian, X., Hellman, J., Dodd-o, J. M., Prakash, A.| | UCSF Research Profile
  4. Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression.
    Liu Q, Tian X, Maruyama D, Arjomandi M, Prakash A| | PubMed
  5. Clinical Evaluation of a COVID-19 Antibody Lateral Flow Assay using Point of Care Samples.
    Lee W, Straube S, Sincic R, Noble JA, Montoy JC, Kornblith AE, Prakash A, Wang R, Bainton RJ, Kurien PA| | PubMed
  6. A journey upstream: Fluctuating platelet-specific genes in cell-free plasma as proof-of-concept for using ribonucleic acid sequencing to improve understanding of postinjury platelet biology.
    Kornblith LZ, Bainton CMV, Fields AT, Matthay ZA, Magid NT, Nunez-Garcia B, Prakash A, Kurien PA, Callcut RA, Cohen MJ, Bainton RJ| | PubMed
  7. Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice.
    Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A| | PubMed
  8. Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice.
    Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A| | PubMed
  9. NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice.
    Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A| | PubMed
  10. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1.
    Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K| | PubMed
  11. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice.
    Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J| | PubMed
  12. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.
    Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J| | PubMed
  13. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
    Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS| | PubMed
  14. Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles.
    Zhang N, Francis KP, Prakash A, Ansaldi D| | PubMed
  15. Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice.
    Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J| | PubMed
  16. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response.
    Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J| | PubMed
  17. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo.
    Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J| | PubMed
  18. Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge.
    Prakash A, Hellman J| | PubMed
  19. Regulation of IRF7 through cell type-specific protein stability.
    Prakash A, Levy DE| | PubMed
  20. Tissue-specific positive feedback requirements for production of type I interferon following virus infection.
    Prakash A, Smith E, Lee CK, Levy DE| | PubMed
  21. Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity.
    Levy DE, Marié I, Prakash A| | PubMed
  22. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.
    Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I| | PubMed
  23. Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback.
    Levy DE, Marié I, Smith E, Prakash A| | PubMed
  24. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.
    Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE| | PubMed
  25. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain.
    Marié I, Smith E, Prakash A, Levy DE| | PubMed