University of California San Francisco

Ari Molofsky, MD, PhD
Ari Molofsky, MD, PhD

Professor, Laboratory Medicine
School of Medicine

Address

513 Parnassus Avenue, HSW, #1201A
San Francisco, CA 94143
United States

Email: [email protected]
Fax: 415-353-1106

ORCID: 0000-0003-0764-3175

Education

Institution Degree Dept or School End Date
UCSF Residency/Fellowship Clinical Pathology / Hematopathology 2011
University of Michigan PhD Immunology & Microbiology 2007
University of Michigan MD Medicine 2007
University of Texas BS Molecular Biology 1999

Awards & Honors

Award Conferred By Date
Most Highly Cited Researchers over past decade, top 1% Clarivate 2022
UCSF Medical School Foundations Curriculum Teaching Award UCSF 2021
American Association of Immunology, Travel Award AAI 2019
Nina Ireland Program for Lung Health Award UCSF 2019
AAI Young Investigator Travel Award UCSF 2017
ICIS Milstein Young Investigator Award UCSF 2017
New Frontiers Research Awardee Program for Breakthrough Biomedical Research UCSF 2017
Larry L. Hillblom Foundation Young Investigator Award UCSF 2016/2019
Mentored Clinical Scientist Research Career Development Award (K08) UCSF 2014
Molecular Medicine Research Fellowship UCSF 2009/2012
MD graduate with research distinction U. of Michigan 2007
Alpha Omega Alpha Medical Honors Society U of Michigan 2006
Ward J. MacNeal Distinguished Dissertation U. of Michigan 2006
Frederick G. Novy Fellowship U. of Michigan 2004/2005
Dean's Honored Graduate in Molecular Biology U. of Texas 1999
National Merit Finalist Scholarship U. of Texas 1995/1999

Collaboration Interests

Our research group is fundamentally collaborative, working to understand tissue immunity across multiple organs and disease states. As our grants and publications suggest, we enjoy pushing the scientific boundaries of immunology and its intersections with neuroscience, metabolic diseases, lung biology, and barrier health.

I am interested in:

  • academic collaboration
  • companies and entrepreneurs
  • physician scientist
  • policy change
  • press

Grants and Funding

  • Manipulation of macrophage polarization by a fungal meningitis pathogen | NIH | 2022-06-23 - 2027-05-31 | Role: Principal Investigator
  • Meningeal type 2 immunity in cortical synapse remodeling during brain development and injury | NIH | 2022-02-15 - 2026-12-31 | Role: Principal Investigator
  • Localization and function of tissue type 2 lymphocytes during mixed inflammation | NIH | 2022-01-11 - 2026-12-31 | Role: Principal Investigator
  • Role of Myeloid And CD4+ T Immune Cells in Post-Traumatic Plasticity | NIH | 2021-12-01 - 2026-11-30 | Role: Co-Investigator
  • The IL-33/ILC2 axis in parturition | NIH | 2020-01-15 - 2024-12-31 | Role: Co-Investigator
  • Defining group 2 innate lymphoid cell lung niches | NIH | 2019-09-01 - 2023-08-31 | Role: Principal Investigator
  • Activation, Phenotype and Function of CD4 T Cells in Schistosoma-Pulmonary Hypertension | NIH | 2016-12-15 - 2021-11-30 | Role: Co-Investigator
  • Defining group 2 innate lymphoid cell lung niches | NIH | 2018-09-15 - 2019-08-31 | Role: Principal Investigator
  • Adipose Tissue type 2 immunity in metabolic health and disease | Larry L. Hillblom Foundation Startup Grant | 2016-08-02 - 2019-07-21 | Role: Principal Investigator
  • Regulation and function of allergic immune cells in visceral adipose tissue | NIH | 2014-05-01 - 2019-02-28 | Role: Principal Investigator
  • Regulation of lung type 2 immunity in tobacco-related allergic asthma | California TRDRP, New Investigator Award | 2018-07-01 - | Role: PI
  • Ghosts in the machine: Lymphocytes in the developing brain | UCSF Quantitative Biosciences Institute Bold and Basic Research Grant | 2017-07-01 - 2018-06-30 | Role: Faculty Mentor
  • Exploring innate lymphocytes at the brain-immune interface | Program for Breakthrough Biomedical Research: New Frontier Research | 2017-06-15 - 2018-06-14 | Role: Co-Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 57
  1. The ins and outs of innate and adaptive type 2 immunity.
    Molofsky AB, Locksley RM| | PubMed
  2. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
    Barron JJ, Mroz NM, Taloma SE, Dahlgren MW, Ortiz-Carpena J, Dorman LC, Vainchtein ID, Escoubas CC, Molofsky AB, Molofsky AV| | PubMed
  3. Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.
    Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T| | PubMed
  4. Circumvention of luteolysis reveals parturition pathways in mice dependent upon innate type 2 immunity.
    Siewiera J, McIntyre TI, Cautivo KM, Mahiddine K, Rideaux D, Molofsky AB, Erlebacher A| | PubMed
  5. Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice.
    Han RT, Vainchtein ID, Schlachetzki JCM, Cho FS, Dorman LC, Ahn E, Kim DK, Barron JJ, Nakao-Inoue H, Molofsky AB, Glass CK, Paz JT, Molofsky AV| | PubMed
  6. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
    Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T| | PubMed
  7. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report.
    Rahimi RA, Cho JL, Jakubzick CV, Khader SA, Lambrecht BN, Lloyd CM, Molofsky AB, Talbot S, Bonham CA, Drake WP, Sperling AI, Singer BD| | PubMed
  8. Bile acid-sensitive tuft cells regulate biliary neutrophil influx.
    O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM| | PubMed
  9. ILC2s - development, divergence, dispersal.
    Ricardo-Gonzalez RR, Molofsky AB, Locksley RM| | PubMed
  10. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
    Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB| | PubMed
57
View all 57 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 57
  1. Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.
    Kumar R, Nolan K, Kassa B, Chanana N, Palmo T, Sharma K, Singh K, Mickael C, Fonseca Balladares D, Nilsson J, Prabhakar A, Mishra A, Lee MH, Sanders L, Kumar S, Molofsky AB, Stenmark KR, Sheppard D, Tuder RM, Gupta MD, Thinlas T, Pasha Q, Graham BB| | PubMed
  2. In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313.
    Nyberg WA, Wang CH, Ark J, Liu C, Clouden S, Qualls A, Caryotakis S, Wells E, Simon K, Garza C, Bernard PL, Lopez-Ichikawa M, Li Z, Seo J, Kimmerly GR, Muldoon JJ, Chen PA, Li M, Liang HE, Kersten K, Rosales A, Kuhn N, Ye CJ, Gardner JM, Molofsky A, Ricardo-Gonzalez RR, Asokan A, Eyquem J| | PubMed
  3. The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles.
    Merrill ED, Prudent V, Moghadam P, Rodriguez A, Hurabielle C, Wells EKC, Basso P, Scharschmidt TC, Rosenblum MD, Molofsky AB, Noble SM| | PubMed
  4. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
    Barron JJ, Mroz NM, Taloma SE, Dahlgren MW, Ortiz-Carpena JF, Keefe MG, Escoubas CC, Dorman LC, Vainchtein ID, Chiaranunt P, Kotas ME, Nowakowski TJ, Bender KJ, Molofsky AB, Molofsky AV| | PubMed
  5. Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.
    Mickael C, Sanders LA, Lee MH, Kumar R, Fonseca-Balladares D, Gandjeva A, Cautivo-Reyes K, Kassa B, Kumar S, Irwin D, Swindle D, Phang T, Stearman RS, Molofsky AB, McKee AS, Stenmark KR, Graham BB, Tuder RM| | PubMed
  6. Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension.
    Fonseca Balladares DC, Kassa B, Mickael C, Kumar R, Nolan K, Menezes TCF, Lee MH, Lau-Xiao AM, Molofsky AB, Wells E, Graham BB| | PubMed
  7. Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading.
    Yadav P, Ortega JG, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Wolters PJ, Tamaki SJ, Bivona T, Abate AR, Wagner A, Tharp KM, Bhattacharya M| | PubMed
  8. Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension.
    Kumar R, Kumar S, Mickael C, Fonseca Balladares D, Nolan K, Lee MH, Sanders L, Nilsson J, Molofsky AB, Tuder RM, Stenmark KR, Graham BB| | PubMed
  9. Type-I-interferon-responsive microglia shape cortical development and behavior.
    Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK, Kaminskaya E, Nakao-Inoue H, Schwer B, Arnold TD, Molofsky AB, Condello C, Andino R, Nowakowski TJ, Molofsky AV| | PubMed
  10. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.
    Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB| | PubMed
  11. The ins and outs of innate and adaptive type 2 immunity.
    Molofsky AB, Locksley RM| | PubMed
  12. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
    Barron JJ, Mroz NM, Taloma SE, Dahlgren MW, Ortiz-Carpena J, Dorman LC, Vainchtein ID, Escoubas CC, Molofsky AB, Molofsky AV| | PubMed
  13. Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.
    Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T| | PubMed
  14. Circumvention of luteolysis reveals parturition pathways in mice dependent upon innate type 2 immunity.
    Siewiera J, McIntyre TI, Cautivo KM, Mahiddine K, Rideaux D, Molofsky AB, Erlebacher A| | PubMed
  15. Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice.
    Han RT, Vainchtein ID, Schlachetzki JCM, Cho FS, Dorman LC, Ahn E, Kim DK, Barron JJ, Nakao-Inoue H, Molofsky AB, Glass CK, Paz JT, Molofsky AV| | PubMed
  16. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
    Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T| | PubMed
  17. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report.
    Rahimi RA, Cho JL, Jakubzick CV, Khader SA, Lambrecht BN, Lloyd CM, Molofsky AB, Talbot S, Bonham CA, Drake WP, Sperling AI, Singer BD| | PubMed
  18. Bile acid-sensitive tuft cells regulate biliary neutrophil influx.
    O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM| | PubMed
  19. ILC2s - development, divergence, dispersal.
    Ricardo-Gonzalez RR, Molofsky AB, Locksley RM| | PubMed
  20. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
    Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB| | PubMed
  21. Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.
    Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD| | PubMed
  22. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.
    Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI| | PubMed
  23. Perivascular stromal cells: Directors of tissue immune niches.
    Sbierski-Kind J, Mroz N, Molofsky AB| | PubMed
  24. Early Life Imprinting of a Th2-Stromal Cell Niche in Skin.
    Ian C Boothby, Devi P Boda, Elaine Y Kwan, Jarish N Cohen, Ireneusz Habrylo, Ari B Molofsky, Michael D Rosenblum| | UCSF Research Profile
  25. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
    Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T| | PubMed
  26. Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.
    Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV| | PubMed
  27. Immune outposts in the adventitia: One foot in sea and one on shore.
    Cautivo KM, Steer CA, Molofsky AB| | PubMed
  28. Tissue immunity broadcasts near and far.
    Molofsky AB, Locksley RM| | PubMed
  29. Adventitial Cuffs: Regional Hubs for Tissue Immunity.
    Dahlgren MW, Molofsky AB| | PubMed
  30. Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury.
    Cameron GJM, Cautivo KM, Loering S, Jiang SH, Deshpande AV, Foster PS, McKenzie ANJ, Molofsky AB, Hansbro PM, Starkey MR| | PubMed
  31. Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.
    Tan C, Mueller JL, Noviski M, Huizar J, Lau D, Dubinin A, Molofsky A, Wilson PC, Zikherman J| | PubMed
  32. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.
    Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB| | PubMed
  33. Tissue signals imprint ILC2 identity with anticipatory function.
    Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM| | PubMed
  34. All along the watchtower: group 2 innate lymphoid cells in allergic responses.
    Dahlgren MW, Molofsky AB| | PubMed
  35. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.
    Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV| | PubMed
  36. B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement: Report of 3 Cases in Adult Patients.
    Li Y, Gupta G, Molofsky A, Xie Y, Shihabi N, McCormick J, Jaffe ES| | PubMed
  37. The Skinny: Pancreatic ILC2s Promote Insulin Secretion.
    Cautivo KM, Molofsky AB| | PubMed
  38. A tissue checkpoint regulates type 2 immunity.
    Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM| | PubMed
  39. Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells.
    Cautivo KM, Molofsky AB| | PubMed
  40. Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.
    Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM| | PubMed
  41. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation.
    Molofsky AB, Savage AK, Locksley RM| | PubMed
  42. A worm of one's own: how helminths modulate host adipose tissue function and metabolism.
    Guigas B, Molofsky AB| | PubMed
  43. Activated type 2 innate lymphoid cells regulate beige fat biogenesis.
    Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A| | PubMed
  44. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.
    Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA| | PubMed
  45. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
    Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM| | PubMed
  46. Peripheral T-Cell Lymphoma, Not Otherwise Specified Presenting as Erythroderma
    Dawson, A.L., LeBoit, P.E., Molofsky, A.B., Ai, W.Z., and Pincus, L.B| | UCSF Research Profile
  47. Type 2 innate lymphoid cells control eosinophil homeostasis.
    Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM| | PubMed
  48. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
    Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM| | PubMed
  49. Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit.
    Rollins MD, Molofsky AB, Nambiar A, Pandey S, Weiskopf RB, Toy P| | PubMed
  50. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
    Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM| | PubMed
  51. Inflammatory Immune Response to Cytosolic Flagellin Protects Mice from Legionella pneumophila Infection.
    Michele S. Swanson, Brenda G. Byrne, Natalie W. Whitfield, Etsu T. Fuse, Kazuhiro Tateda, Ari B. Molofsky| | UCSF Research Profile
  52. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection.
    Molofsky AB, Byrne BG, Whitfield NN, Madigan CA, Fuse ET, Tateda K, Swanson MS| | PubMed
  53. Autophagy and inflammatory cell death, partners of innate immunity.
    Swanson MS, Molofsky AB| | PubMed
  54. Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death.
    Molofsky AB, Shetron-Rama LM, Swanson MS| | PubMed
  55. Differentiate to thrive: lessons from the Legionella pneumophila life cycle.
    Molofsky AB, Swanson MS| | PubMed
  56. The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye.
    Patterson K, Molofsky AB, Robinson C, Acosta S, Cater C, Fischer JA| | PubMed
  57. Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication.
    Molofsky AB, Swanson MS| | PubMed